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Active substance: Potassium Aspartate and Magnesium Aspartate) A12CX Mineralizing Preparations Others Pharmacological groups Macro and trace elements in combinations Antiarrhythmic drugs in combination Nonological Classification (ICD-10) E87.6 Hypokalemia I25.9 Chronic ischemic disease Hearts are unspecified I49.9 heart rhythm violation I50.9 heart failure uncomfortable T46.0 Cardiac glycosides poisoning and similar effects Composition and form of release in contour cellular packaging 50 pcs.; In a pack of cardboard 1 package. Description of the dosage form White tablets with a smooth surface, flat-cylindrical, with risky. Pharmachologic effect Pharmacological action - metabolic, replenishing magnesium and potassium deficiency. Indications of the drug asparkam In the complex therapy of the following diseases and states: heart failure; hypokalemia; disturbance of cardiac rhythm (including with myocardial infarction, overdose of heart glycosides). Contraindications acute and chronic renal failure; hypercalemia. Side effects Possible nausea, unpleasant sensations or burning in the opposite region (with cholecystitis and ancidn gastritis). These phenomena usually pass with a reduction in the dose of the drug. Interaction Asparks lower sensitivity to cardiac glycosides. Method of application and dose Inside, usually adults - 1-2 table. 3 times a day after meals. Course treatment - 3-4 weeks. If necessary, it can be repeated. Precautionary measures With rhythm violations, in combination with AV blockade, the drug is not recommended. The sharing of asparkama and potassium-saving diuretics increases the risk of hypercalemia. |
Lazix® (Lasix®) Registration number:
P N014865 / 01-011108
Trade name of the drug: Laziks ®.
International UnPatented Name (Inn) - Furosemid
Dosage form:
pills
Structure One tablet contains: active substance: furosemide (rubbed) - 40 mg Auxiliary substances: lactose, starch, starch preephalinated; talc; silicon colloidal dioxide; magnesium stearate.
Description White or almost white round tablets with "DLI" engraving above and below the risks on one side.
Pharmacotherapeutic Group:
diuretic.
ATX code - C03S01.
Indications for use
Entry syndrome in chronic heart failure;
eternity syndrome in chronic renal failure;
acute renal failure, including those in pregnancy and burns (to maintain the excretion of the liquid);
Entry syndrome with nephrotic syndrome (with nephrotic syndrome in the foreground is the treatment of the underlying disease);
Entry syndrome for liver diseases (if necessary, in addition to the treatment of aldosterone antagonists);
Arterial hypertension.
Contraindications
Increased sensitivity to active substance or any of the components of the drug; In patients with allergies on sulfonamida (sulfonyllamide antimicrobial agents or preparations of sulfonylurea), it can be cross allergies for furosemide;
renal failure with Anuria (in the absence of a reaction to furosemide);
Hepatic coma and prema;
pronounced hypocalemia;
pronounced hyponatremia;
hypovolemia (with or without arterial hypotension) or dehydration;
sharply pronounced disorders of the urine outflow of any etiology (including one-sided lesion of urinary tract);
Digital intoxication;
acute glomerulonephritis;
Decompensated aortic and mitral stenosis, hypertrophic obstructive cardiomyopathy;
increase in central venous pressure (over 10 mm Hg. Art.);
hyperuricemia;
childhood up to 3 years (solid dosage form);
breastfeeding period.
Carefully: arterial hypotension; conditions under which an excessive decrease in blood pressure is particularly dangerous (sobering damage to coronary and / or brain arteries); acute myocardial infarction (increase in the risk of developing cardiogenic shock), latent or manifest diabetes; gout; hepatorenal syndrome; Hypoproteinemia, for example, with nephrotic syndrome, in which it is possible to reduce the diuretic effect and increasing the risk of developing furosemide output, so the selection of doses in such patients should be carried out with special caution); impairment of urine outflow (prostate hypertrophy, narrowing of the urethra or hydronephrosis); Pancreatitis, diarrhea, ventricular arrhythmias in history, systemic red lupus.
Pregnancy and breastfeeding period Furosemide penetrates the placental barrier, so it should not be appointed during pregnancy. If the Lazix life testimony is prescribed to pregnant women, then careful observation of the state of the fetus is necessary. In the period of breastfeeding, the reception of furosemide is contraindicated. Furosemide suppresses lactation.
Method of application and dose General Recommendations: Tablets should be taken on an empty stomach, not chewing and drinking a sufficient amount of fluid when appointing a laziz is recommended to use its lowest doses sufficient to achieve the necessary effect. The recommended maximum daily dose for adults is 1500 mg. In children, the recommended dose for intake is 2 mg / kg of body weight (but not more than 40 mg per day). The duration of treatment is determined by the doctor individually depending on the testimony.
Special recommendations for the dosing regime in adults: Entrance syndrome with chronic heart failure The recommended initial dose is 20-80 mg per day. The required dose is selected depending on the diuretic response. It is recommended that the daily dose shall be divided into two or three receptions. Entrance syndrome with chronic renal failure Sodium-repeatic reaction to furosemide depends on several factors, including the severity of renal failure and sodium content in the blood, so the effect of the dose cannot be exactly predictable. In patients with chronic renal failure, careful selection of a dose is required, by gradually increase so that the loss of fluid takes place gradually (at the beginning of treatment it is possible to loss of liquid to approximately 2 kg of body weight per day). The recommended initial dose is a dose of 40-80 mg per day. The required dose is selected depending on the diuretic response. The whole daily dose should be taken once or share for two receptions. In patients on hemodialysis, usually supporting dose is 250-1500 mg / day. Acute renal failure (to maintain the removal of fluid) before the start of treatment with furosemide, hypovolemia, arterial hypotension and significant disorders of the electrolyte and acid-alkaline state should be eliminated. It is recommended to transfer the patient from the intravenous introduction of the lazix to the reception of the laziz tablets (dose of the lazix tablets depends on the selected intravenous dose). Edema with nephritic syndrome The recommended initial dose is 40 - 80 mg per day. The required dose is selected depending on the diuretic response. The daily dose can be accepted in one reception or share for several techniques. Entraward syndrome with Lazix liver diseases is appointed in addition to the treatment of aldosterone antagonists in case of their insufficient efficiency. To prevent the development of complications, such as a violation of the orthostatic regulation of blood circulation or a violation of the electrolyte or acid-alkaline state, a thorough selection of the dose is required so that the loss of fluid takes place gradually (at the beginning of treatment there is a loss of liquid to approximately 0.5 kg of body weight per day). The recommended initial dose is 20-80 mg per day. The arterial hypertension of Laziks can be used in monotherapy or in combination with other hypotensive means. An ordinary maintenance dose is a dose of 20-40 mg per day. In arterial hypertension, combined with chronic renal failure, it may be necessary to use higher doses of Lazix.
Side effect From the side of the aqueous-electrolyte and acid-alkaline state hypocalemia, hypochloremia, hypokalemia, hypomagnemia, hypocalcemia, metabolic alkalosis, which can develop in the form of or gradual increases of electrolyte deficit or massive loss of electrolytes for a very short time, for example, in the case of high doses in the case of taking high doses Furosemide patients with normal kidney function. The symptoms indicating the development of violations of the electrolyte and acid-alkaline state, there may be headache, confusion of consciousness, convulsions, tetania, muscle weakness, heart rate disorders and dyspeptic disorders. Factors contributing to the development of electrolyte violations are the main diseases (for example, cirrhosis of the liver or heart failure), concomitant therapy and improper power. In particular, when vomiting and diarrhea may increase the risk of hypokalemia. Hypovolemia (decrease in circulating blood) and dehydration (more often in older patients), which can lead to hemoconcentration with a trend towards the development of thrombosis. From the side of the cardiovascular system, an excessive decrease in blood pressure, which, especially in the elderly patients, can manifest itself in the following symptoms: disruption of the concentration of attention and psychomotor reactions, headache, dizziness, drowsiness, weakness, visual disorders, dryness in the mouth, imbalance of orthostatic regulation blood circulation; collapse. From the metabolism side, improving serum levels of cholesterol and triglycerides. The transient increase in the level of creatinine and urea in the blood, increasing the serum concentration of uric acid, which can cause or enhance the manifestations of the gout. Reducing glucose tolerance (possible manifestation of latent flowing diabetes mellitus). From the side of the urinary system, the appearance or strengthening of symptoms caused by an obstacle to urine outflow up to an acute urine delay with subsequent complications (for example, with prostate hypertrophy, the narrowing of the urethra, hydronephrosis); Hematuria, reducing potency. From the gastrointestinal tract is rare - nausea, vomiting, diarrhea, constipation; Individual cases of intrahepacine cholestasis, increasing the level of hepatic transaminases, acute pancreatitis. On the part of the central nervous system, the hearing body in rare cases - hearing impairment, usually reversible, and / or noise in the ears, especially in patients with renal failure or hypoproteinemia (nephrotic syndrome), rarely paresthesia. From the side of the skin, allergic reactions are rarely allergic reactions: skin itching, urticaria, other types of rash or bullous lesions of the skin, polymorphic erythema, exfoliative dermatitis, purpura, fever, vasculitis, interstitial jade, eosinophilia, photosensibilization. Extremely rarely, severe anaphylactic or anaphylactoid reactions up to shock, which have to date have been described only after intravenous administration. From the side of peripheral blood is rarely thrombocytopenia. In rare cases of leukopenia. In some cases, agranulocytosis, aplastic anemia or hemolytic anemia. Since some adverse reactions (such as a change in blood pattern, severe anaphylactic or anaphylactoid reactions, heavy skin allergic reactions) under certain conditions can threaten the life of patients, then when any side effects appear, you must immediately inform them to a doctor. Overdose With suspected overdose, it is necessary to consult a doctor, as in the case of an overdose, it may be necessary to conduct certain medical events. The clinical picture of acute or chronic overdose of the drug depends mainly on the degree and consequences of loss of fluid and electrolytes; Overdose can manifest itself with hypovolemia, dehydration, hemoconcentration, heart rate impaired and conductivity (including atrioventricular blockade and ventricular fibrillation). The symptoms of these disorders are arterial hypotension (up to the development of shock), acute renal failure, thrombosis, nonsense, sluggish paralysis, apathy and confusion of consciousness. Specific antidote does not exist. If a little time has passed after intake, it should be tried to cause vomiting from the gastrointestinal tract to reduce the furosemide absorption from the gastrointestinal tract, and then take the activated carbon inside. The treatment is aimed at correcting clinically significant disorders of the aqueous-electrolyte and acid-alkaline state under the control of serum concentrations of electrolytes, indices of acid-alkaline state, hematocrit, and preventing or therapy of possible serious complications developing against the background of these violations.
Interaction with other medicines Cardiac glycosides, drugs causing the elongation of the Qt interval-in case of development against the background of the furosemide of electrolyte disorders (hypocalemia or hypomagnemia) increases the toxic effect of cardiac glycosides and drugs causing the intervention of the Qt interval (the risk of rhythm violations increases). Glucocorticosteroids, carbenoxolone, laccs in large quantities and long-term use of laxatives with combination with furosemide increase the risk of hypokalemia. Aminoglycosides - a slowdown in the removal of aminoglycosides by the kidneys when they are simultaneously use with furosemide and an increase in the risk of developing the isotoxic and nephrotoxic effects of aminoglycosides. For this reason, the use of this combination of drugs should be avoided except when it is necessary on life indications, and in this case it is necessary to correlate (decrease) supporting doses of aminoglycosides. Drugs with nephrotoxic effects - when combined with furosemide, the risk of developing their nephrotoxic action increases. High doses of some cephalosporins (especially having predominantly renal extinguishing path) - in combination with furosemide, the risk of nephrotoxic action increases. Cisplatin - while using furosemide, there is a risk of developing a dyotoxic action. In addition, in the case of joint assignment of cisplatin and furosemide in doses above 40 mg (with normal kidney function), the risk of developing the nephrotoxic effect of cisplatin is increasing. Non-steroidal anti-inflammatory drugs (NSAIDs) - NSAIDs, including acetylsalicylic acid, can reduce the diuretic effect of furosemide. In patients with hypovolemia and dehydration (including on the background of furosemide), the NSAIDs may cause the development of acute renal failure. Furosemide can enhance the toxic effect of salicylates. Phenitoine is a decrease in the diuretic effect of furosemide Hypotensive agents, diuretics or other means capable of reduced blood pressure - with a more pronounced hypotensive effect, a more pronounced hypotensive effect is expected. Inhibitors of angiotensin-converting enzyme (ACE) - the appointment of an ACE inhibitor to patients who previously obtained a furosemide treatment may result in an excessive decrease in blood pressure with a deterioration in the kidney function, and in some cases - to the development of acute renal failure, therefore, three days before the treatment of inhibitors APE or enhance their dose is recommended for the cancellation of furosemide, or a decrease in its dose. Probricide, methotrexate or other drugs, which, like furosemide, are secreted in renal-cats, can reduce the effects of furosemide (the same way of renal secretion), on the other hand, the funk can lead to a decrease in the extinguishing of the kidney of these drugs. Hypoglycemic agents, pressing amines (epinephrine, norepinephrine) - weakening effects when combined with furosemide. Theophylline, diazoxide, stripped muscle relaxants - enhancing effects when combined with furosemide. Salts of lithium - under the influence of Furosemide, the excretion of lithium is reduced, due to which the serum concentration of lithium is increasing and the risk of developing the toxic effect of lithium, including its damaging effect on the heart and the nervous system increases. Therefore, using this combination requires control of serum concentrations of lithium. Sukralfat is to reduce the suction of furosemide and attenuating its effect (furosemide and sucralfat should be made at an interval of at least two hours). Cyclosporine A - with a combination with furosemide, the risk of the development of gouty arthritis is increasing due to hyperuricemia caused by furosemide, and violations of the cyclosporine excretion of urates by the kidneys. X-ray-repeat substances - in patients with high risk of nephropathy for the introduction of X-ray-contrast drugs obtained by furosemide, a higher frequency of development of the renal function was observed compared to patients with high risk of nephropathy for the introduction of radiopyase preparations, which were obtained only intravenous hydration before administration of an X-ray-contrast preparation.
Forms of release Tablets of 40 mg. 10 tablets in the strip made of aluminum foil. 5 strippers in a cardboard pack together with the instructions for medical use. 15 tablets in the strip made of aluminum foil. 3 Streaps in a cardboard pack together with medical instructions.
Asparkama is one of their essential drugs, a source of magnesium and potassium.
Elements are in the form, which allows the body almost 100% to learn these two components. Positively affecting the cardiovascular system, muscular fabric, asparks are not a hormonal agent. Therefore, actively applied athletes.
On this page you will find all the information about Asparkov: Complete instructions for use in this medicinal medium, average prices in pharmacies, full and incomplete analogues of the drug, as well as reviews of people who have already used asparks. Want to leave your opinion? Please write in the comments.
Clinical and Pharmacological Group
The drug compensating for potassium and magnesium deficiency in the body.
Conditions of vacation from pharmacies
Released without a doctor's prescription.
Prices
How much is asparks? The average price in pharmacies is at the level of 55 rubles.
Release form and composition
A preparation is produced in the form of tablets and a solution of d / and.
- White tablets with a specific smell, have a plane-cylindrical shape and a smooth surface, with a risk of diameter. 50 pcs are packaged. In blister, one blister in the package. Aspark tablets include 0.175 g of each of the active substances, as well as corn starch, talc, calcium stearate and polysorbat-80.
- The injection solution has a white or slightly yellowish liquid. On sale enters ampoules 5 or 10 ml (package number 10). The composition of asparkama produced in the form of a solution of D / and is anhydrous magnesium asparaginate and anhydrous potassium asparaginat in a concentration of 40 and 45.2 mg / ml, respectively (equivalent to 3.37 mg of magnesium and 10.33 mg of potassium), as well as adding E 420 (sorbitol) and water d / and.
Pharmacological effect
Asparkov is a source of such important substances such as potassium and magnesium. It contributes to the normalization of the electrolyte balance. Magnesium is a cofactor of a set of enzyme reactions (about 300) and promotes potassium penetration into cells. Potassium also has an antiarrhythmic effect, and also maintains normal heart performance.
After applying asparkam, its components are quickly absorbed into the gastrointestinal tract. The conclusion of the drug is carried out mostly through the kidneys. After 1-2 hours after taking the aspark tablets or injection injection, the concentration of active substances (magnesium and potassium) in the blood reaches the maximum level. From the blood plasma, the drug penetrates cardiomyocytes in the form of Mg2 + and K + ions, as well as asparaginata, immediately, including in cellular metabolism.
Indications for use
Asparks are shown in the integrated therapy of the following diseases and conditions:
- Heart rate disorders (paroxysmal superstricular, atrial and ventricular extrasystole) caused by various reasons, including with and overdose of heart glycosides;
- Digital intoxication (bad tolerability or poisoning with cardiac glycosides);
- Ischemic heart disease (IBS);
- Post-infarction period.
In addition, asparks as an independent drug preparation is shown for use in hypokalemia and hypomagniasia of any origin. In the hypomagnemiology and hypokalemia asparks are used until the normalization of the concentration of magnesium ions and potassium in the blood.
It should be known that asparks can be used to eliminate potassium deficiency and magnesium of any origin, for example, after multiple vomiting, diarrhea, nex-saving diuretic reception (for example, furosemide), laxatives and glucocorticosteroids.
Contraindications
The drug is contraindicated at:
- hypermagnia- or hypercalemia;
- acute metabolic acidosis;
- cardiogenic shock (when systolic pressure does not exceed 90 mm Hg. Art.);
- atrioventricular blockade (ABB) II-III degree;
- severe miastic;
- hypersensitivity to the substances included in its composition;
- OPN and CPN;
- oliguria, Anuria;
- hypocorticism;
- hemolysis;
- dehydration.
With caution, asparks should be used in pregnant and nursing women, with urine diathesis (associated with impaired ammonium phosphate, Ca2 + and Mg 2+), hypophosphatems, ABB I degree. Additional contraindications for parenteral use of the drug are children's age, pronounced liver failure, risk of edema, metabolic acidosis.
Application during pregnancy and lactation
Asparks can be appointed pregnant women in the event of symptoms of potassium deficiency and in preventive purposes.
Instructions for use
In the instructions for use, it is indicated that taking tablet asparks should be orally after eating.
- Adults must be taken 1-2 tab. 3 r. / Day.
- The reception scheme is prescribed by a doctor. The course of therapy comes from the disease. On average, it lasts 8-10 days. When the reception of the tablets is inexpedient, an intravenously drip or inkjet method is assigned. In both cases, the liquid is introduced slowly.
The dosage is also denoted by a specialist. Intravenous infusion requires 1-2 ampoules of 10 ml or 2-4 ampoules of 5 ml. The contents are divorced in 100-200 ml of 0.9% sodium chloride solution. Pour the drug for 25 caps. per minute 1-2 r. / d.
Do they appoint to aspark kids?
This drug is prescribed to children solely if the potassium deficiency is observed. This phenomenon is quite dangerous - potassium must be present in all cells of the human body, in order to ensure the normal function of all tissues, as well as organs. If the child has hypochalemia - it is fraught with complications in the form of heart impairment, as well as the development of convulsion.
Side effects
Asparks may have side effects. If you discovered the following symptoms after taking the drug, immediately stop the course of treatment and consult with your attending physician to avoid the appearance of irreversible processes.
Symptoms indicating the negative response of the body to the adoption of the drug:
- Dizziness, feeling of weakness.
- The feeling of muscular weakness.
- Allergic rash, itching.
- Frequent vomit urge.
- The appearance of a liquid chair.
- Dry feeling in the mouth.
- The appearance of meteorism.
- A sharp decline in the pressure in the artery.
- Excessive selection of sweat.
- Violation of respiratory processes.
- Venous thrombosis.
Overdose
The main symptoms of overdose by the drug include hypercalemia and hypermagnias, which manifest themselves in the form of redness of the face, increased thirst, arterial hypotension, disorders of neuromuscular transmission, arrhythmia, seizures and oppression of the respiratory center.
In the case of observing such symptoms during the use of aspark tablets or during its intravenous administration, it is necessary to immediately apply for advice to the doctor.
special instructions
In cases of long-term use of asparkam, it is important to regularly monitor the level of magnesium and potassium in the blood, as well as monitor the data of the electrocardiogram and electrolyte hemostasis indicators.
- The safety of the use of funds for children is currently not defined.
- When appropriate means with oral shapes of tetracycline, sodium fluoride and iron salts should be borne in mind that asparks inhibit their suction, so it is necessary to withstand the three-hour interval between medications.
- Due to the fact that potassium ions are included in the preparation, while the asparkama with ACE inhibitors, cyclosporin, potassium-saving diuretics and beta-adrenoblockers, significantly increases the risk of developing hypercalemia and inhibition of intestinal peristals.
Medicinal interaction
Asparks can be used comprehensively with the rest of the drugs. You should be careful because the active substance of this drug is compatible not with all drugs. This can cause many unwanted consequences, side effects.
Therefore, familiarize yourself with the list of drugs, combining asparkam with which is possible either strictly contraindicated:
- Asparks can be combined with preparations that contain a flutter or stanfantine.
- The central nervous system is oppressed if you align asparks with anesthesiological preparations.
- Asparks are not required if you use diuretic preparations that contain potassium-saving drug components.
- "Cyclosporin". Also contains potassium-saving components, so incompatible with aspark.
- Betta-adrenoblocators (similar to the previous preparation).
- The effectiveness of antibiotics is significantly reduced if a person takes asparks in parallel.
- If you combine drugs that contain tetracycline, sodium fluoride, iron - you will get the effect of reducing the toxic effects of cardiac glycosides on the myocardine muscle.
Asparkamka is a source of potassium and magnesium ions.Promotes the restoration of the electrolyte balance. Potassium has an antiarrhythmic effect, supports normal cardiac activity. Magnesium is a cofactor of 300 enzyme reactions, promotes potassium penetration into cells. It is used in digitalisane intoxication, heart failure, myocardial infarction, arrhythmias (paroxysmal superstricular tachycardia, atrial and ventricular extrasystole) against the background of hypokalemia or hypomagnemiology (vomiting, diarrhea, therapy of saluretics, GKS, laxatives).
- warns or eliminates hypokalemia;
- improves metabolism in myocardium;
- a reliable antiarrhythmic effect after myocardial infarction and heart failure;
- improves the tolerance of cardiac glycosides in heart failure;
- excellent portability in the absence of pro-amateur action.
Latin name:
Asparkam / Asparcam.
Composition and form of release:
Asparkam Tablets for 350 mg of 10 or 50 pcs. packaged.
1 Tablet Asparkam Contains 175 mg of potassium aspartate and 175 mg of aspartate magnesium.
Asparkam Solution for injection in ampoules of 20 ml of 10 pcs. packaged.
1 ampoule Asparkam Contains 0.9 g of potassium asparaginata and 0.8 g of magnesium asparaginata.
ASPANGIN; Asparkad; Asparkam (Asparkam-L); Asparka-AKOS; Asparkov-Ros; Aspark-UFF; Asparkam-Pharmac; Asparka-Fereyn; Potassium and magnesium asparaginat; Potassium magnesium-asparaginat; KMA Berlin Hemi; Pamaton; Panangin.
Potassium and magnesium asparaginat (aspartate) - a combination of proven in practice in heart rate disorders, carrier of potassium and magnesium ions through the cell membrane.
Active-active substance:
Potassium and magnesium Asparaginat (Aspartate) / Potassium Aspartate and Magnesium Aspartate.
Dosage forms:
Pills.
Injection.
Solution for infusion.
Potassium and magnesium asparaginat
Properties / Action:
Potassium and magnesium asparaginat (Aspartate) is the source of potassium and magnesium ions.
Potassium It is the main intracellular cation in most tissues. Potassium ions slow down the excitation in the myofibrils and reduce myocardial excitability.
Magnesium It is a metabolic cofactor in many enzymatic reactions, in the frequency of energy disposal by the body. It is necessary for the normal functioning of sodium-potassium-ATP-azno and calcium-ATP-nuclear pumps. Magnesium is involved in controlling the balance of intracellular potassium.
Asparaginat It is a carrier of potassium and magnesium ions through the cell membrane and contributes to their penetration into intracellular space. Entering the cells, ions are included in metabolic processes.
Pharmacokinetics:
Clinical data on pharmacokinetics of potassium and magnesium asparaginate are limited.
Indications:
- hypokalemia caused by the use of diuretics (saluretics - dichloatiazide, furosemide, stacrinic acid, indapamide, oxodoline, etc.);
- potassium or magnesium shortage having various reasons.
As part of combined therapy with: - angina;
- myocardial infarction;
- heart failure;
- disturbations of heart rate (including arrhythmia caused by overdose of heart glycosides, with paroxysmal arrhythmia, ventricular extrasystole).
Method of use and dose:
Dosage of potassium and magnesium asparaginata should be selected individually, depending on the indication for the use and degree of hypokalemia.
Pills:
Inside after meals. Adults 1 to 2 tablets or dragee (one-time dose is ~ 500 mg) 3 times a day for 3-4 weeks or longer.
With a prophylactic target or with supporting therapy, 1 tablet or dragee is prescribed 3 times a day. The duration of therapy is established individually.
Injection.
Intravenously introduced 10-20 ml 1-2 times a day for 5 days. The contents of 1-2 ampoules are pre-bred in 100-200 ml of a 5% solution of glucose or sterile water for injection. Inject drip at a speed of 25 drops per minute. You can breed the contents of 1 ampoule in 20 ml of 5% glucose or sterile water for injection and introduce inkido, at a speed of 5 ml / min.
Solution for infusion:
Only for intravenous use. A week before cardiac surgery and within a week after surgery, a heart is introduced at 500 ml per day. Introduction speed: 15-45 drops per minute depending on individual tolerance.
Overdose:
It is manifested by a conduction disorder, especially at the preceding pathology of the conductive system.
Treatment. Alignment of the liquid and electrolyte balance by administering corrective electrolytes, for example, which contain sodium or calcium ions, and / or stimulation of removal from the body of superproduced amounts of electrolyte - if necessary, through the use of artificial kidney.
Contraindications:
- severe disorders of the kidney function (with acute and chronic kidney fails);
- insufficient urica;
- increased maintenance of potassium or magnesium in the blood (hypercalemia, hypermagniamia);
- atrioventricular blockade of 2-3 degrees at normal circalemia;
- erythrocyte damage (hemolysis);
- adrenal failure;
- shock state;
- acute acid acidosis;
- dehydration;
- heavy Myastenia Gravis (Miasthenia);
- treatment accompanied by delaying from the potassium body.
Application during pregnancy and lactation:
It is possible to use during pregnancy and during lactation (breastfeeding) in the presence of indications.
Side phenomena:
From the digestive system: nausea, vomiting, diarrhea are possible.
From the cardiovascular system: possible violations of myocardium conductivity.
From the CNS: dizziness.
Other: irritation of veins walls (when in / in administration).
Symptoms of hypercalemia and hypermagneziemia (with in / in administration): thirst, redness of the face, muscle weakness, hypothexy, fatigue, paresis, cramps, respiratory depression, decrease in blood pressure, paradoxical reaction in the form of an increase in the number of extrasystole, coma.
Special instructions and precautions:
Potassium and magnesium asparaginat can only be used carefully weighing the benefit ratio and risk at:
- availability of av-blockade;
- severe liver failure;
- metabolic acid acidosis;
- dangers of edema development;
- limited kidney function - if regular control over the content of magnesium in serum is impossible (the risk of cumulation, toxic level of magnesium);
- reduced blood phosphate level.
Together with potassium and magnesium asparaginat, if necessary, it is necessary to introduce stanfantine or drugs.
Intravenous administration should be made slowly. With a quick / in the introduction, hypercalemia and hypermagnias are possible. Use only transparent solutions! After opening the capacity, the drug must be immediately used. Do not mix with other injection or infusion solutions (clouding or opalescence).
Medicinal interaction:
The simultaneous use of potassium-saving diuretics (spironolactone) and / or inhibitors of angiotensin-converting enzyme (ACF inhibitors, ACE - Captopril, Enalapril, etc.) can lead to hypercalemia and hypermagnesemia.
When used together with cardiac glycosides (digoxin, etc.), the side effects of the latter are significantly reduced.
Storage conditions:
The drug should be stored in light-protected place.
The shelf life is specified on the package.
Conditions for leave from the pharmacy - according to the doctor's prescription.
thanks
The site provides reference information solely to familiarize yourself. Diagnosis and treatment of diseases must be under the supervision of a specialist. All drugs have contraindications. Consultation of a specialist is obligatory!
Asparkam It is a source of potassium and magnesium, since it contains these elements in the form that allows them to pass into the cells and completely absorbed. The drug restores the electrolyte balance, if it was broken, and is a source of potassium and magnesium for the body.Potassium has an antiarrhythmic effect, thereby maintaining the normal and regular work of the heart without arrhythmias. Magnesium is involved in ensuring more than 300 different biological reactions in the human body needed to maintain vital activity and normal metabolism. In addition, magnesium improves penetration of potassium ions inside cells.
Asparks are used in heart failure, myocardial infarction, arrhythmias, to eliminate the inxication phenomena caused by the use of cardiac glycosides (stanfantine, digoxin, korglikon, digitoxin, codonid, etc.), as well as to restore the balance of ions during potassium deficiency (hypokalemia) and magnesium ( hypomagnemiia) in the body.
Asparkov - composition, form of release, dosage, varieties
Today, under one common name "Asparkamka" means several varieties of the drug produced by various pharmaceutical enterprises under different names. As a rule, these names always contain the word "aspark", to which several letters are added relating to a multiple name of an enterprise that manufactures this particular drug, for example, "Aspark-Fereyn", "Asparkam-Pharmak", etc. All these varieties of the drug differ from each other only by the names that they were given the leaders of enterprises, since they are manufactured according to the same technology developed in the USSR.Different names for the same asparkama are necessary in order to register products of any pharmaceutical enterprise in the market. The fact is that in the period of the USSR, all pharmaceuticals produced medicines on the same technologies and under the same name, for example, acetylsalicylic acid was called only this way, although it could be produced in Nizhny Novgorod, Perm, Novokuznetsk, etc. And at present, each plant has become a separate enterprise and it needs to register its unique names of drugs. And since many of these drugs are made from the period of the USSR, their names are not fundamentally changed, but simply add letters or words to be considered unique. But, in fact, this is all the same drug made by the same technology with different pharmaceutical plants.
In addition, some varieties of asparkama can be produced only in one dosage form, since the company has been worked out by the production technology of this form, and not any other. For example, "Asparkam-Pharmac" and "Aspark-Feren" are made only in the form of a solution for injections, and the pills on the data of pharmaceutical enterprises are not issued, since there is no necessary technology or there is no possibility to master it.
So, at present, various pharmaceutical plants produce the following varieties of asparkama:
- Asparks;
- Asparkam-L;
- Asparkov-Ros;
- Aspark-UFF;
- Asparkam-Pharmac;
- Asparkam-Feraine.
The varieties of asparkam are produced in the following dosage forms:
- Tablets for intake (Asparkamka, Asparkov-Ros, Asparkov-UFF);
- Solution for intravenous injection in ampoules of 5 ml, 10 ml and 20 ml (asparks, asparkam-L, aspark-pharmac, asparka-Feren);
- A solution for intravenous infusions - "droppers" in bottles of 200 ml and 400 ml (asparkam-L).
Different dosage forms of asparkam contain the following quantities and magnesium in the form of asparaginat:
- Tablets - 175 mg of potassium asparaginata and 175 mg of magnesium asparaginata (175 + 175);
- A solution for injection - 40 mg of magnesium of asparaginata (3.37 mg of pure magnesium) and 45.2 mg of potassium of asparaginata (10.33 mg of pure potassium) in 1 ml;
- The solution for infusions is 7.9 g of the magnesium of asparaginata and 11.6 g of potassium asparaginata in 1 liter.
Therapeutic effects of Asparkama
Asparkov is a source of potassium and magnesium ions, respectively, its therapeutic effects are due to the action of these chemical elements. First of all, asparks eliminates the imbalance or deficiency of potassium and magnesium in the body, and also has the ability to regulate the metabolism processes, since these ions are involved in many biochemical reactions in all organs and tissues. Potassium is the main intracellular positive ion in all organs and tissues. Being inside the cell in sufficient quantity, potassium stimulates the synthesis of ATP (adenosineryphorphosphoric acid), glycogen, proteins and acetylcholine.
ATP is a universal energy molecule that is necessary for the flow of any reactions and the implementation of cell functions. According to her ATP role, you can compare with gasoline for the engine of the car. That is, without ATP cell simply will not be able to do anything, even provide its own food and reproduction. Potassium, stimulating the synthesis of ATP, allows the cell to get a large amount of energy, which is enough for the performance of specific functions (for example, muscular contractions, production of hydrochloric acid, etc.), and on the formation of molecules for its own power, and to replace "old" , "worn" proteins new.
Stimulation of glycogen synthesis allows the Cell to create a strategic supply substance that, when hunger, you can quickly turn into ATP. That is, under the influence of potassium cells create reserves of peculiar "semi-finished products" for periods of life, when there are little energy.
Stimulation of protein synthesis allows the cell to replace the "old" molecules in a timely manner, which are already poorly coping with their functions, new, which have the ability to work quickly and easily. Such a phenomenon can be compared with the replacement of old and worn spare parts by car or any other instrument. Naturally, after replacing the old spare parts, the device will work better. The same thing in the cells of the body - the replacement of old proteins new allows cellular elements to work better, more efficiently and longer.
Stimulation of acetylcholine synthesis allows the cell to speed up the various signals on nerve fibers, since this substance is a mediator that performs the function of nerve activation.
Thus, potassium ions accelerate the cell's work, increase its efficiency, and also allow you to quickly respond to teams from nerve trunks and create reserves of energy substances.
Magnesium requires more than 300 enzymes to work, which provide metabolism and the implementation of the specific functions of each cell cell. Also, magnesium participates in the cascade of the responses of ATP synthesis and regulates potassium balance. Thus, magnesium enhances potassium effects and makes cell work more efficiently, faster and versatile.
In addition, joint potassium and magnesium ions support the necessary polarization of cell membranes, which is necessary for effective separation of the external environment and internal cell cytoplasm. Due to this distinction of media, unnecessary and harmful substances do not fall inside the cells, and the products of metabolism are output from it.
Asparaginat is the carrier of potassium and magnesium ions through the membrane inside the cells. After penetrating the cell, potassium and magnesium are released due to the asparagin, and it is included in the metabolism process. Asparaginat improves the synthesis of replaceable amino acids, nucleotides for DNA and lipids. In addition, the asparaginat optimizes the energy exchange in the heart muscle experiencing oxygen starvation, for example, with ischemic disease, atherosclerosis, etc.
It should be remembered that asparks have all the above effects in the cells of all organs and tissues, but they are most noticeable with respect to the heart. Therefore, asparks are traditionally used in the complex treatment of heart disease, especially arrhythmias, since in relation to this, the most important organ has the following effects:
- Prevents and eliminates hypokalemia (potassium deficiency in blood);
- Improves metabolism in the heart muscle;
- Eliminates arrhythmias arising after myocardial infarction or against heart failure;
- Improves the tolerance of cardiac glycosides (stanfantine, digoxin, corgal cryolism, digitoxine, celaminide, etc.);
- Increases the endurance of the heart and allows you to carry out more physical work and transfer much stronger emotions.
Asparkov - indications for use (for which they use)
Asparks are shown in the integrated therapy of the following diseases and conditions:- Heart failure;
- Ischemic heart disease (IBS);
- Post-infarction period;
- Heart rate disorders (paroxysmal superstricular tachycardia, atrial and ventricular extrasystole) caused by various reasons, including with myocardial infarction and overdose of heart glycosides;
- Digital intoxication (bad tolerability or poisoning with cardiac glycosides).
In addition, it is necessary to select recommendations separately (which can be considered to be considered to be applied) on the use of asparkam in sports:
- Long and intense physical exertion;
- Overtraining;
- Cardiopsychoneurosis;
- Violation of cardiac rhythm.
Asparkov - instructions for use
Consider the rules for the use of various asparkama dosage forms in separate sections to avoid confusion.Asparks Tablets
The tablets should be swallowed entirely, not schoing, not chewing, not fluttering and non-shredding in other ways, but by drinking a small amount of water (enough half of the glass). Reception of asparkama for preventing potassium and magnesium deficiency, as well as in sports, produced 1 tablet 3 times a day after meals. The duration of preventive reception is determined individually and can be long. When taking asparcama, longer than 4 weeks are recommended every 7 - 14 days to take blood test to determine the concentration of potassium and magnesium. If those be located on the upper boundary of the norm or to exceed it slightly, then for a while stop taking asparkama. In such a situation, it will be possible to resume the preparation of the drug only when concentrations of potassium and magnesium in the blood will be devastated to normal values.
Neither with therapeutic, nor with preventive objectives should be taken more than 6 tablets asparkam per day, since excessively high dosages of potassium and magnesium are not absorbed, but simply displayed with urine. That is, 6 tablets accepted during the day, and everyone else will simply be removed from the body. Attempts to take more than 6 pills asparkam per day are only in an increased burden on the kidneys, which can negatively affect their operation and, accordingly, human well-being.
Instructions for the use of solutions for intravenous injections and for infusion
Solutions for infusion and injections are entered intravenously exclusively for treatment and never for prevention and in sports. In order to increase the endurance of the heart and prevention of potassium and magnesium deficiency, asparks should be taken only in tablets. Injection solutions are produced in 5 ml ampoules, 10 ml and 20 ml under the names of asparks, aspark-L, asparkam-pharmac, aspark-Feren and have the same concentrations of potassium and magnesium. The solution for infusions is available in bottles of 200 ml and 400 ml called Asparkam-L.
Injection solutions can be introduced insertion (slowly release the jet directly from the syringe) or use to prepare a solution for infusion ("dropper"). The infusion solution is used only for drip administration, that is, in order to call "dropper" in everyday life.
Only transparent solutions for injection and infusion should be used. If the bottle or in the ampoule is a muddy solution, it should be thrown out. After opening the ampoule or bottle, it is necessary to immediately use the solution. If, after mixing asparkam in one syringe or bottles with other solutions for infusions, it happened, then such mixtures cannot be entered, they need to be disposed.
With therapeutic purposes in the composition of complex therapy of various diseases of the heart, solutions for the injection of asparkam are injected daily by 10 - 20 ml 1 - 2 times a day for five days. A half of the physiological solution or a 5% solution of dextrose solution is added to Asparkamu, for example, 5 ml of physiological solution or a 5% solution of dextrose solution, etc., are added to Asparkama. The ampoules with the necessary amount of asparkam are opened immediately before the injection and the desired amount of solution in the syringe with a thin needle is gaining. Then, in the same syringe, another half of the physiological solution or a 5% solution of dextrose is gaining, after which it germs gently its contents using slopes in different directions. Then the finished solution is introduced into Vienna slowly, at a speed of at least 5 ml per minute.
The solution for infusions is used only for "droppers", that is, intravenously drip. With therapeutic purposes, 300 ml of the finished solution for infusion 1 - 2 times a day are administered for a maximum of 5 days. The solution is introduced at a speed of 20 - 30 drops per minute (1 - 1.5 ml per minute).
If there is no solution for infusion for any reason, but it is necessary to introduce a person asparks in the form of "dropper", then you can use ampoules with a solution for injection. In this case, the solution for infusions is prepared from the solution for injections. For this, 100 ml of physiological solution or a 5% solution of dextrose was added for every 10 ml of solution for injections from ampoules.
That is, if a person needs to introduce 300 ml of infusion solution, then to obtain it, it should be pulled out from ampoules 30 ml of solution for injections and add 300 ml of saline to it. The solution thus obtained for infusions is also introduced at a speed of 20 - 30 drops per minute.
Special instructions and precautions
Asparks in any dosage form should be used with caution and only under the control of the doctor if the following diseases have the following diseases and states:- AV blockade (atrioventricular blockade);
- Severe liver failure;
- Metabolic acidosis of blood;
- High risk of edema;
- Violation of kidney functions;
- Low blood phosphates.
Overdose
Overdose aspark is possible only with intravenous solutions and is manifested by the following symptoms:- Bradycardia (heartset slowing);
- Decrease in blood pressure;
- Vascular collapse;
- Diastolic stop of the work of the heart;
- Vomiting;
- Lethargy;
- Weak bladder;
- Heart Blockers;
- Breath paralysis;
- Paralysis of the heart muscle with a heart stop.
When taking tablets, the overdose of aspark was not fixed never.
Interaction with other medicines
The use of asparkama depresses the intestinal peristaltics and provokes constipation, and also increases the risk of hyperkalemia (elevated blood potassium level) due to the excess accumulation of potassium ions in combination with the following drugs:- Potassium-saving diuretic drugs (for example, Veroshpiron, Spironolactone, etc.);
- ACE inhibitors (captopril, Ramipril, Enalapril, etc.);
- Beta adrenoblocators (non-bilette, concor, anaprilin, betok zok, etc.);
- NSAIDs (aspirin, indomethacin, paracetamol, ibuprofen, nimesulide, etc.);
- Cyclosporin.
Asparks reduce toxicity and improves the tolerance of cardiac glycosides by eliminating their side effects.
When using nex-saving diuretic drugs (Furosemide, etc.) and glucocorticosteroids (dexamethasone, prednisone, etc.), simultaneous reception of asparkama fills potassium losses and prevents hypokalemia.
Asparks enhances the effects of antide -olarizing muscle relaxants (pypecuronium, punchonia, tubocurarine, etc.) and drugs for anesthesia (ketamine, hexenal, etc.), but reduces the severity of neomycin antibiotics, polymixin in, tetracycline and streptomycin.
Aspark children and infants
Asparkov for children over the year and infants are appointed only in cases where the potassium deficiency is revealed (hypokalemia) based on the results of laboratory surveys. If hypocalemia was revealed from the results of the blood test on the ions, regardless of the reasons that provoked this violation, asparkama tablets are prescribed to the child. Intravenous injections are extremely rare, only in the event of a threat to life. Hypokalemia in children is manifested by lethargy, drowsiness, apathy, muscle weakness, falling blood pressure, arrhythmia and tachycardia (palitium). If the baby is breast, then in addition to the specified signs of hypokalemia, dry skin dryness, increased gas formation, poor chest sucking and frequent joins, up to vomiting.
Hypokalemia in a child of any age can develop for the following reasons:
- Repeated vomiting;
- Diarrhea for a minimum of day;
- Severe liver or kidney diseases;
- Diseases of the digestive tract;
- The use of glucocorticoids;
- Application of nex-saving diuretics;
- Intravenous administration of glucose solutions, proteins and salts without potassium.
As a rule, at hypokalemia and arrhythmia, children are recommended to give asparks within 1 - 2 weeks in the following dosages:
- Children under the year - 1/4 tablets for 1 time per day;
- Children 1 - 3 years - 1/2 tablets for 1 time per day;
- Children 3 - 6 years old - 1/2 tablets 2 times a day;
- Children 7 - 10 years - 1/2 tablets 3 times a day;
- Children 11 - 12 years old - 1 tablet 1 - 2 times a day;
- Children 13 - 16 years - 1 tablet 2 times a day;
- Children 16 years old - 1 tablet 3 times a day.
If a child takes diuretic drugs or glucocorticoids that contribute to the removal of potassium from the body, the doctors are always additionally prescribed asparks in preventive dosages to prevent hypokalemia development. A combination of diakarb (diuretic drug) + Asparkov has become literally classical appointed infants to reduce increased intracranial pressure. In this case, asparks and diakarb are appointed by a specific scheme for a long time.
Application during pregnancy
In the instructions for use, it is indicated that asparks can be used during pregnancy with caution. This is quite true, since asparks do not harm the fetus and mothers, if used by testimony, and not just, "for prevention". Preventive courses for receiving this drug during pregnancy should not be made, as this can lead to ion imbalances, for example, an increase in the concentration of potassium and magnesium in the blood above the norm, which, in turn, can provoke severe complications up to the loss of pregnancy.Asparkama during pregnancy can be taken simultaneously with non-blocking diuretic, as well as to improve the work of the heart, if the ECG has functional disorders. In addition, you can use asparks with short courses for 1 to 2 weeks for hypokalemia prevention, if a woman often has vomiting or diarrhea. In such cases, optimally take 1 tablet asparkam 3 times a day during the week after 2 episodes of vomiting or diarrhea.
Application for various purposes not designated in the instructions
Asparks and Riboxin + Asparkoms in Bodybuilding
In bodybuilding or sports, asparks separately or in combination with riboxin are taken to increase endurance, increase the time of efficient training, as well as power and cardion. In addition, asparks separately or in combination with riboxin improves the condition and increases the productivity of the work of the athlete's heart, preparing and adapting it to high physical exertion, which, in turn, prevents sudden death from stopping the heart, associated with the fact that the body simply could not Loads. Asparkov is a source of potassium and magnesium, which reduce the heart rate and allow you to hold the pulse when loads in the required boundaries. That is, when using asparkam, even on the background of intense power or cardionage, the heart is not beating as often and strongly, as without this drug. In addition, potassium and magnesium ions are well relaxing muscles, eliminate excessive tension and remove cramps. And since with any power loads, potassium and magnesium are intensively consumed, the reception of asparkama makes it possible to replenish the level of ions in the blood and cells and make training more efficiently.
Riboxin increases the volume of blood discharged and the power of heart cuts, which improves the blood supply to all organs and tissues in the body. In addition, riboxin provides muscle recovery after intensive workout, stops arrhythmia and helps to restore the structure of myocardial cells, which eliminates cardiomyopathy. Separately, it is worth noting useful for athletes and bodybuilders anabolic effect of the drug, which allows you to quickly recruit muscle mass.
Thus, both drugs are useful for athletes and bodybuilders, however, they are most often used in the complex, since asparks additionally enhances the effects of riboxin. Asparks are recommended to take 1 tablet 3 times a day for a month, and riboxin - 2 tablets 3 times a day also within a month. Courses of receiving each drug separately or a mixture asparks + riboxin can be repeated every 3 months.
Asparks for weight loss
Currently, the drug is quite widely used for weight loss, with some people combine it with diet and physical exertion, while others - with the reception of diuretic products. Reception of asparkam in order to accelerate weight loss and achieving the best results on the background of the diet compliance, especially tough, and the fulfillment of physical exercises is justified and useful. The fact is that, subject to a diet, a person does not receive many of the substances you need in sufficient quantities, including potassium and magnesium, which slows down the metabolism and extension the process of weight loss.
Asparks makes it possible to fill the deficit of these elements in food and ensure their admission to the body in sufficient quantities. And potassium and magnesiums contained in asparkama increase the effect of diet and exercise, since they accelerate the metabolism, optimize the work of the muscles and speed up the removal of toxins formed as a result of the collapse of fat cells, as a result of which a person accepting asparks will lose faster and stronger that Does not use this drug.
Thus, the use of asparkam for weight loss in combination with diet and physical exertion is rational and useful. In this case, the drug is recommended to take 1 tablet 3 times a day for 2 to 4 weeks.
Application for the purpose of slimming of diuretic (furosemide, diakarba and other) drugs in combination with aspark is unjustified and dangerous. The fact is that under the influence of diuretic drugs from the body, liquid is derived and dehydration occurs. Of course, due to such a reception, the weight may decrease by several kilograms, but due to dehydration, and not the decay of fat deposits, which in itself is dangerous. In this case, asparks only prevents the decrease in the concentration of potassium in the blood, since these ions are derived by the kidneys under the action of diuretic drugs, but does not replenish the loss of fluid and does not prevent the dangerous effects of dehydration.
How to take asparks with diuretic drugs?
Diakarba or furosemide and aspark
The combinations of diakarba + asparks and furosemid + asparks are most often appointed in the complex therapy of increased blood pressure and swelling, including the brain, and the main acting drug in it is diakarb or furosemide. In addition, this combination of drugs is used in all cases when the use of diuretics is necessary.The fact is that diakarb and furosemide are diuretic drugs, and therefore effectively remove fluid from the body, thereby reducing the volume of circulating blood, which naturally leads to a decrease in blood pressure. In addition, responding to a decrease in the volume of circulating blood, water from tissues also begins to go out and join the bloodstream, which, in turn, eliminates swelling.
Asparks in these combinations are needed to replenish potassium in the blood, since diakarba and furosemide derive this trace element from the body. That is, asparks leverals the side effect of diakarba and furosemide, which allows the diuretic to use a sufficiently long period of time required to achieve the desired clinical effect.
Diakar and asparkam baby
The diakarb and asparks are prescribed to the reduction of intracranial pressure, the elimination of the cyst and brain dysfunction, as well as the removal of the excessive amount of liquid from the ventricles of the brain. Under the action of diakrab from the body, water is derived, as a result of which the liquid from the tissues (in this case of the brain) enters the blood, and the brain edema, high pressure and cysts are eliminated.Diakarb must be used in combination with asparks, since it displays potassium from the body, and its deficit can lead to severe complications, up to a heart stop. And in order to prevent potassium deficiency, together with diakrab, you need to apply asparks, which is the source of magnesium and potassium ions, which allows you to fill their number in the body.
Dapacan and asparks are prescribed in the following schemes:
1.
Take 1/4 asparkam tablets and 1/4 diakar tablets per day every three days within a month. That is, one day should be given to the child drugs, not give three days, etc.
Contraindications for use
The use of asparkama is contraindicated in the presence of the following states and diseases:- Acute or chronic renal failure;
- Low blood pressure (for injection);
- Hypercalemia (elevated blood potassium level);
- Hypermagnalia (elevated level of magnesium in the blood);
- Small urine (less than 1 liter per day);
- Atrioventricular blockade of 2-3 degrees;
- Hemolysis (destruction) of red blood cells;
- Adrenal failure;
- Acute acid acidosis;
- Dehydration;
- Severe miastic;
- Methanol poisoning;
- Addison syndrome;
- Amino acid exchange violation.
Analogs
In the domestic pharmaceutical market, the analogues of Asparkama include drugs that also contain potassium asparaginat and magnesium asparaginate as active substances. Such analogues of Asparkama include the following drugs:- ASPANGIN;
- Potassium and magnesium asparaginate Berlin Hemi;
- Potassium and magnesium asparaginat;
- Pamaton;
- Panangin;
- Panangin Forte.
Asparkov - Reviews
Almost all feedback on asparkam (more than 97%) is positive, which is due to pronounced and well-visible clinical effects of the drug, which significantly improve the overall human condition, normalize the work of the heart, eliminate the convulsions and a number of other unpleasant symptoms caused by the disadvantage of potassium and magnesium.Most of the positive feedback on Asparkame concerns its use in serious illness or functional impairment of the heart. People who took asparmets in the complex therapy of coronary insufficiency, IHD and other heavy heart pathologies, note that they began to feel much better, the portability of physical and emotional loads increased, the sensations of heartbeat and fading disappeared. And people who took asparks about the functional impairments of the heart (for example, a feeling of pain, fading, mad or uneven heart knock, myocardiodestrophia, a sharp increase in the pulse in physical and emotional loads, etc.), it is noted that the drug completely eliminated all negative Symptoms and normalized analyzes and surveys. After the course of accepting Asparkama, people suffering from functional impairments of the heart of the heart, because of which they did not receive admission to sports training or it was difficult for them, they became completely healthy, and doctors allowed them physical exertion in any volume.
A slightly smaller part of Asparkame reviews concerns its effectiveness to eliminate seizures in the limbs arising for various reasons. In response, people note that literally after 2 - 3 weeks of use, the drug completely eliminated convulsions and muscle overvoltage that do not work normally, sleep and relax well. Asparks are effective for relieving seizures and in pregnant women.
Women note that asparks reduce breast swelling and fluid delay in the body in front of menstruation, and also reduces the severity of other symptoms
Asparkov is a drug - a source of magnesium and potassium ions, which regulate the metabolic processes in the body. The means contains aspartate - transfer of ions through cell membranes. The drug is prescribed for diseases associated with impaired heart rate, during angina and for preventing stroke.
Available asparks in tablets and in the form of a solution for injections.
pharmachologic effect
According to the instructions, Asparkama is a source of such important substances such as potassium and magnesium. It contributes to the normalization of the electrolyte balance. Magnesium is a cofactor of a set of enzyme reactions (about 300) and promotes potassium penetration into cells. Potassium also has an antiarrhythmic effect, and also maintains normal heart performance.
After applying asparkam, its components are quickly absorbed into the gastrointestinal tract. The conclusion of the drug is carried out mostly through the kidneys. After 1-2 hours after taking the aspark tablets or injection injection, the concentration of active substances (magnesium and potassium) in the blood reaches the maximum level. From the blood plasma, the drug penetrates cardiomyocytes in the form of Mg2 + and K + ions, as well as asparaginata, immediately, including in cellular metabolism.
Indications for the use of asparkama
According to the instructions, asparks are shown:
- To improve the efficiency and tolerability of cardiac glycosides;
- As part of the complex therapy of heart failure, heart rate disorders, the state after the myocardial infarction;
- Under states that are accompanied by hypomagnia and hypokalemia.
Contraindications for use
The use of asparkama is contraindicated in the following diseases and physiological characteristics of patients:
- Acute and chronic renal failure;
- Increased sensitivity or intolerance to the components of the LAN;
- Addison disease;
- Cardiogenic shock (blood pressure<90 мм. рт. ст.);
- Hypermagniamia and hypercalemia;
- Atrioventricular blockade of 2-3 degrees.
Ways to use asparkama
Aspark tablets take orally. The dosage is 1-2 pieces. Three times a day. Acceptance of aspark tablets is recommended immediately after meals.
When using the dose solution is 10-20 ml, it is administered intravenously 1-2 times a day. In this case, the course of treatment lasts 5 days. However, the exact dosage and the duration of treatment appoints a doctor, depending on the type and course of the disease, as well as the general state of the patient and its history of the disease.
Side effects of asparkama
In the instructions for asparkam, it is indicated that the side effects are developing extremely rarely. However, the reception can lead to failures in the work of the digestive system, namely nausea, vomiting, pain in the abdomen, diarrhea, gastrointestinal bleeding, unpleasant sensations in the epigastric area, dryness in the mouth, the ulcer of the mucous membrane.
Also, according to the reviews of Asparkam, there may be disorders from the cardiovascular system: a decrease in blood pressure, a violation of myocardial conductivity, AV blockade.
Allergic reactions in response to reception means can manifest itself to redness of the skin, itching and rash.
According to the reviews of Asparkam, some patients complain about convulsions, paresthesia and hyperreflexia, which is a violation of the work of the central nervous system and the peripheral nervous system.
Occasionally, breathing may arise, which is due to hypermagniasia. In addition, some reviews about Asparkam are talking about such a side effect like a feeling of heat.
As for the drug overdose, today it was not fixed. However, according to the instructions, asparks in large quantities, theoretically can lead to such symptoms: nausea, vomiting, metal taste in mouth, abdominal pain, weakness, bradycardia, muscular paralysis, disorientation, paresthesia limbs, thirst, redness of the skin of the face, arterial hypotension, Cramps, impairment of neuromuscular transmission, arrhythmia. In this case, it is necessary to stop taking asparkama to conduct symptomatic therapy, including intravenous administration of the calcium solution chloride in a dosage of 100 mg / min. In case of need for the patient, hemodialysis is carried out.
Storage conditions
Additional Information
Diakarb is a medicine that is often prescribed in cases of increased intraocular or intracranial pressure. Often in the recipe there is a combination "Dapacarb and Asparkam" - their physicians are prescribed together. The fact is that the second drug helps to prevent the side effects of the first.
In the treatment of diakrab, the body loses a large number of sodium ions and, accordingly, potassium, which can lead to negative consequences.
Potassium is a vital element involved in cellular metabolism. Especially myocardium needs - heart muscle. Also, the body is experiencing a need for magnesium, which takes part in carbohydrate exchange and transports energy to each cell for biochemical reactions.
Normal heart rhythm is characteristic of myocardium when it reacts to an increase in magnesium concentration with decrease in excitability and conductivity. But with a large number of potassium, the contractile ability of the heart muscle is oppressed, which can entail a heart stop. Such an effect is possible when overdosing asparkamom, introduced intravenously.
Potassium deficiency is accompanied by the appearance of lethargy, muscle weakness, heart rate disruption, reduced performance.
Asparkov also restores the content of potassium and magnesium, contributes to the rapid penetration of these substances into the cells. Thanks to the reception of asparkam with diakrab, the rehabilitation of osmotic pressure in the cells, ensuring their sufficient energy. Also, the combination with aspark increases blood acidity and displays bicarbonates from the body.
The simultaneous reception of Diakarba and Asparkama allows you to compensate for the side effects of the first in the form of loss of potassium ions and an increase in blood alkalinity.
Neurologists often prescribe these drugs to patients in order to reduce intracranial pressure under different diseases and the consequences of traumatic brain damage.