Koldakt is a modern medicinal drug that successfully fights against the symptoms of GRVI and influenza. It can be taken with the use of antibiotics and oral preparations to speed up the process of expecting the patient.
The newest form of release of the drug is Coldact Flu plus capsules. Koldakt may be mostly positive.
This drug copes with its tasks. Vin effectively lowers body temperature, improves nasal congestion, democratic at a price. However, patients report drowsiness as a partial side effect.
Indications and contraindications before congestion
Koldakt zastosovuєtsya, zgidno z іnstruktsiєyu, for the usunennia symptoms of influenza and GRVI, such as: undead, fever and pain syndrome, lacrimation, fever.
In the yakost contraindication for the receptionist Koldakt you can see:
- individual intolerance of components;
- circulatory diabetes;
- thyrotoxicosis;
- coronary atherosclerosis;
- hypertension;
- critocutaneous glaucoma;
- decreased activity of glucose-6-phosphate dehydrogenase;
- aches and pains of the slugs;
- prostate adenoma due to obstruction of sechoviprosy;
- disease of the circulatory system;
- virazka;
- Vіk up to 12 years;
- taking MAO inhibitors.
Zastosovuvati z berezhnistyu in bronchial asthma, obstructive ailment, and hyperbilirubinemia. The drug is not recommended until zastosuvannya with pregnancy and lactation, but there are no reliable results about the safety of this drug for children. For an hour, the drug can not be taken with alcohol.
Interaction with others
Pіd hour likuvannya Koldaktom Flu Plus live sleepy and tranquilizers are not recommended. It is contraindicated when Koldakt is taken with other paracetamol drugs.
Psychotropic drugs and phenothiazine drugs when taken with Koldaktom, the development of dryness in the mouth, constipation, stuttering of the cut should be treated.
With paracetamol, rifampicin, barbiturates, carbamazepine, zidovudine and diphenin are not recommended. The effect of uricosuric effects is reduced when taken together with paracetamol.
Chlorphenamine when taken together with Furazolidone, the morbidity of hyperrexia, arousal, hypertensive crisis.
Tricyclic antidepressants increase the strength of adrenomimetic action of phenylephrine. Interactions with Halothane can lead to slunar arrhythmias.
Side effects
When taking Koldaktu, you may experience: tachycardia, nudota, paralysis of acomodation, drowsiness, loss of appetite, constipation, exfoliation of the mucous membranes, expansion of the sinuses, increased internal pressure, increased epigastric pain, anemia.
Some patients may have thrombocytopenia, leukemia, agranulocytosis. Rarely, they can blame the zatrimka of the battle, allergy.
Respect! Prolongation by taking macrodoses Koldaktu can lead to damage to the liver and liver. In case of an overdose of the drug (taking over 10-15 g per doba), you may experience a severe disorder. Next to promit the tube in the first 6 years with the following symptoms: tedium, bleakness of the skin, vomit, pharynx.
With vipadic overdose of Koldaktu it is necessary to return to the polyclinic, to bring on the symptoms of otruennya until you are afraid. Do not varto engage in self-admiration. hypothetically possible severe health consequences of people.
In the period of taking the drug, there may be an increase in the reaction to the drugs and a significant decrease in the concentration of respect for the rachunok of a weak sedative drug. Patients need to be careful when caring for transport during the entire period.
Warehouse for the drug and medicinal forms
Koldakt is released at the sight:
- Trivalo's capsules;
- syrup;
- suspensions;
- tablets for dissolution;
- powders for the preparation of rozchin.
The dermal medicinal form of Koldaktu is unique and may have its own dosing, it is necessary to report the instructions before stopping, in order to eliminate the side effects of this drug.
According to the instruction, Koldakt put two active components at the warehouse: Phenilephrine and chlorphenamine maleate as well as additives of speech, which make the gelatin shell of the capsules. Chlorpheniramine is a histamine H1 receptor blocker. Repair anti-allergic diarrhoea, succumb to tears. Usuvaє sverbіzh at the empty nose and eyes. May have a sedative and antimuscarinic effect.
Phenilephrine is used for swelling and redness of the mucous nose and exudate.
The preparation of creations in such a rank, that the components that were developed, were progressively differentiated in the herbal tract of people, which significantly prolonged the last hour of the effective injection of the drug on the symptoms of illness. In this way, the need for frequent use of the drug is established.
Suspension Koldakt navpaki, not covered for a prolonged day. Vaughn vmoktuetsya quickly and conquer. Vіdsotkovyj in place of active components in suspension lower, lower in capsules. Die troch more than 4 years old.
Koldakt Flu Plus Capsules Trivaloї Dії include active ingredients: chlorphenamine maleate, paracetamol, phenylephrine and additional speech. The drug is progressively distributed in the intestines and the action of active components lasts up to 24 years.
Paracetamol is known for antipyretic and analgesic speech. Fight with sore throat, m'yazah, suglobah, lowering the temperature.
Syrup Coldact Broncho Remedy: Ambroxol hydrochloride, Chlorphenamine maleate, Guaifenesin, Phenilephrine.
Koldakt Lorpils tablets for rozmoktuvannya place at your warehouse: amylmetacresol and dichlorobenzyl alcohol. Additional words: orange oil, sucrose, water, citric acid and other.
coldact flu plus activates alpha-adrenergic receptors, sounds like judges, changes redness and inflammation of the mucous membranes of the nose, reduces the amount of exudate vision. Vіn buy allergic reactions for additional blocking of histamine receptors, succumbing and tearing. Paracetamol in stock may have an antipyretic effect.
Save 2 rocks Coldact Plus, 3 rocks - Coldact.
Koldakt instruction from zastosuvannya
Get ready to get bogged down by people for 12 years. Dosage: one capsule with an interval of 12 years.
As a treatment for influenza and GRVI, the drug zastosovuetsya in 1 to 3 days, allergic rhinitis in 3 to 6 days, sinusitis - about 6 days. As an antipyretic Coldact is taken for 3 days, as an antipyretic no more than 6 days.
Syrup Koldakt Broncho for children before zastosuvannya need to be taken care of. Take for 5 days to fight against cough and important phlegm.
For patients over 12 years of age, take 4 teaspoons (20 ml), 3 times per doba.
Children from 6 to 12 years of age take 10 ml (2 teaspoons) 2-3 times per day.
Koldakt Lorpils
Tablets need to be taken by mouth, not broken.
Let's grow up, we need 2:00 to take 1 tablet (no more than 8 pieces per doba). Children from 5 years of age give 1 tablet every 4 years.
Price on the Russian market
Russia does not allow, but to import this drug from India. The price of the drug is not expensive for 100 rubles in different regions of Russia. Irrespective of those that Coldact is allowed without a prescription, it is necessary to consult a doctor about possible side effects.
Koldakt vidguki
"I drank Coldact Fly plus an hour of colds. They ran into their zavdannya for 4+."
"I'm taking Coldact at once. I don't want to lose my opinion, I didn't mention the shards of a special effect, but the next day I received a significant improvement. Undead may be proishov.
Mykola Do.
"I am addicted to such preparations, before going to the pharmacy I read the instructions about the drug. I can say for sure that Coldact Flu Plus helped me to cope with the flu epidemic."
Coldact Flu Plus is a drug that is prescribed as a symptomatic treatment for the presence of acute respiratory illnesses.
How to order Coldact Flu Plus warehouse and release form?
Pharmaceutical industry viroblya Koldakt Flu Plus in capsules, stinks of prolonged (trivalo) dії. The dosage form of the drug contains active drugs, zocrema: phenylephrine hydrochloride at a dose of 25 mg, additions of chlorphenamine maleate at a dose of 8 mg, in addition, ½ 200 mg of paracetamol.
What is the use of Coldact Flu Plus drug?
Combination drug Koldakt Flu Plus may be prolonged diy, yogo medicinal infusion is explained by the presence of a number of active speeches. Zokrema, є chlorphenamine, tsya half-way on the body anti-allergic effect, suvaє slezotech, as well as sverbіzh.
The offensive component is paracetamol, which may have an antipyretic effect on the body, may have an analgesic effect, slightly change the severity of the pain syndrome, which often accompanies a cold, increases pain in the throat in the head, passes mialgiya, decreases movement puppy temperature.
Active speech phenylephrine may have a vessel-sounding effect, as a result, tissue swelling changes, reddening of the mucous membranes of the sinuses of the nose and upper dycal passages.
What are the faces of Coldact Flu Plus showing before the zastosuvannya?
The drug is used as a symptomatic therapy for colds, flu, and is accompanied by rhinorrhea, fever and pain syndrome.
What are Coldact Flu Plus contraindications before zastosuvannya?
I’m overwhelmed if Coldact Flu Plus has contraindications to zastosuvannya:
With closed-cut glaucoma;
When sensitiveness rises to components of faces;
Blood diabetes;
Don't wink over when diagnosing thyrotoxicosis;
Atherosclerosis of the coronary arteries;
Virazkov's disease;
Contraindications - arterial hypertension;
With the manifestation of the pathology of the subscapular burrow;
Until the twelfth century;
Prostate adenoma due to twisting sechoviprosy;
Illness of the circulatory system, liver, nirok, sich mikhura.
For protection, Coldact Flu Plus is prescribed for congenital hyperbilirubinemia, obstructive ailment, and also for bronchial asthma.
Yaki u Koldakt Flu Plus zastosuvannya dozuvannya?
We are older to prescribe Coldact Flu Plus for this capsule for two days, if you want, you can come in for three days up to five days, if you need to consult a doctor.
Zokrema, as an antipyretic drug, can be used for no more than three debuffs, but for the presence of a pain syndrome, the drug can be used for five days.
Paracetamol, present in this drug, may cause hepatotoxicity in concomitant disease with barbiturates, rifampicin, diphenin, as well as with carbamazepine and other liver enzyme inducers.
Sleepiness with etanol may have a sedative effect. There may be a risk of developing constipation, hiccups and dryness in the mouth with one-hour treatment with Coldact Flu Plus with antidepressants, antipsychotic drugs, phenothiazine drugs, and also with antiparkinsonian drugs.
Overdosing with Koldakt Flu Plus
An overdose of the drug can lead to the development of an offensive complex of symptoms: blіdіst skіrnіvі pokrivіv, due to a decrease in appetite, the manifestation of nudity is characteristic, vomitting occurs, in severe cases, hepatonecrosis is not excluded, it is laboratory indicated.
After the poisoning with the drug in the shortest term, proceed before washing the drain, administer the SH-group donor to the patient. If necessary, the hospitalization of the patient to the hospital is ordered, to give the whole range of necessary medical visits.
What are the effects of Coldact Flu Plus?
Patients who live in combination with Coldact Flu Plus, instructions for taking the drug “ahead”, about those who are suffering from the onset of side effects. For example, this way - increased blood pressure, confusion, typical tachycardia, drowsiness, widening of the jaw, impaired sinus, increased alertness, moreover, dryness of the mucous membranes, paresis of accommodation , anemia, not included is an increase in the internal pressure, as well as pain in epigastrium, boredom.
It is rare to finish the zatrim of the battle, allergic reactions are observed at the sight of hanging on the shkir, it is possible to have a drop in the throat, an angioneurotic swelling is caused. The laboratory shows agranulocytosis and thrombocytopenia. With a trivalent glee, there is a hepatotoxic disease.
especially vkazіvki
As soon as an hour of treatment with Coldact Flu Plus, the patient does not have fever, it is necessary to return to the doctor in a term. It is not possible to take medicine with alcohol drinks, as well as medicines, such as paracetamol.
How to replace Coldact Flu Plus, analogues like vikoristovuvat?
The drug prescription of AntiFlu, in addition, the drug TeraFlu Extratab is up to analogs.
Visnovok
The drug should be lived for a long time, indications in the instructions until the liquid is stuck, otherwise you can put it on the side of the liver.
Not a lot of facts about the product:
Installation instructions
Price in the Internet pharmacy site: view 180
Not a lot of facts
Coldact Flu Plus - combinations of anticongestive, antipyretic and analgesic drugs. Before this warehouse, there are three active components, one of which may manifest antihistamine power. Victory in palliative therapy for the treatment of cold symptoms - nasal congestion, fever, sore throat, hyperthermia, rhinorrhea, lacrimation, etc.
Nosological classification of ailments (MKH-10)
Combinations of anti-cold zasib zastosovuetsya for the treatment of a number of groups of respiratory diseases:
- J06 - multiple infectious inflammation of the upper respiratory tract;
- J06.9 - severe septic inflammation of the nasal emptying and laryngopharynx;
- J30.4 - inflammation of the mucous nose of an allergic genesis;
- J10 - sickly camp, provoked by the influenza virus;
- R50 - hotbed of unclear etiology.
The medical warehouse and the form of release
Coldact Flu Plus is found in the form of red-white capsules of prolonged duration, placed in the intestinal lining with gelatin. Vmist capsules є sumishshu z red and white granules, in which the offensive speech is located:
- chlorphenamine - 8.0 mg;
- phenylephrine - 25.0 mg;
- paracetamol - 200.0 mg;
- methyl hydroxypropylcellulose;
- disodium goes;
- ester of phthalic acid;
- polyvinylpyrolidon;
- isopropyl alcohol;
- distilled water;
- gelatin;
- sucrose;
- dextrinmaltose;
- stabilizer E462;
- sodium disulfide;
- grub barvniki.
Capsules are packaged in a blister plate of 10 pieces. The dark blue box contains 1 plate with capsules and detailed instructions on how to apply an anti-cold remedy.
Therapeutic powers
Medication Koldakt Flu Plus can be anti-seizure, antipyretic, protinabryakov and analgesic. The therapeutic effect of the pharmacological powers of such active components:
- Chlorphenamine is a blocker of histamine H1 receptors from the alkylamine group, which may have antiallergic (antihistamine) power. Usuvaє mucosal swelling, rhinorrhea, lacrimation and other allergic symptoms;
- Paracetamol is an analgesic of the antipyretic group of anilides, which buys painful sensations. Ignore the production of mediators of inflammation, which leads to symptoms of hyperthermia and pain syndrome;
- Phenilephrine is an anticongestive drug from the group of alpha-adrenergic agonists that induces vasoconstrictor action in the mucosal nasopharynx. Changes in the penetration of the capillary walls, for which there is hyperemia and swelling in the nasal canals.
In case of congestion of capsules, symptoms of allergy, nasal congestion, low-grade febrile fever and other manifestations of GRH are commonly observed. The combination of the medication made it easier to overcome not only colds, but also sinusitis.
Indication before zastosuvannya
Antipyretic for pain-relieving and pro-allergic disease in symptomatic therapy of infectious inflammation of the upper respiratory tract. Indication before recognition of the combined case є:
- subfebrile temperature;
- viral nasopharyngitis;
- nasal congestion;
- body aches;
- cold;
- headaches;
- myalgia;
- rhinorrhea;
- hot syndrome;
- sinusity.
Anticongestive capsules reduce swelling in the nasal emptying, for which the viscous secretion from the paranasal sinuses normalizes. In combination with cym Coldact Flu Plus, it is recommended to use vicorist for the prevention of sinusitis and sphenoiditis with infectious lesions of the mucous membrane of the nasopharynx.
Dosing mode
Capsules should be taken internally afterward. Trivality of exaltation and dosing to fall due to the severity of symptoms of GRH. Older and older children of 12 years of age are prescribed 1 capsule 2 times per day. It is recommended to drink them with still water. The course of therapy may be revisited for 5-7 days. For the presence of a therapeutic effect, it is necessary to turn to an otolaryngologist.
Combinations of faces do not vicorize in the case of the triumph of ailments, as they did not reach the 12th century. Paracetamol, which enters the capsule storage, at high doses negatively affects the functioning of the organs of the hepatobiliary system. Therefore, they are not assigned to persons with a body weight of up to 40 kg.
Come in later
According to the instructions from the zastosuvannya, the components of the drug are metabolized by the vast majority of the world for the help of liver enzymes. In case of advanced parenchymal tissue and impaired inactive liver function, change the additional dose of the combined preparation to 1 capsule.
For the sake of safety, it is necessary to take capsules for persons with hypertensive ailment, prostate hyperplasia, intracranial hypertension, and overcritical glaucoma. Phenilephrine may have a vasoconstrictor effect on the judge, which can lead to worsening symptoms of other illnesses.
As an anti-cold zastosovuetsya over 7 days later, it is necessary hour after hour to monitor hemodynamic indicators in the blood and glomerular filtration rate. Ignorance of these rules is threatening with the development of nirk deficiency, as well as damage to the functions of the cystic brain.
Gestation and breastfeeding
Protipozuvannya antipyretic in the period of gestation. Its active component, paracetamol zocrema, is negatively injected into the intrauterine development of the fetus. With vicarious capsules in the 1st and 2nd trimesters of pregnancy, there is a risk of development of cryptorchidism in boys. In the case of an anti-cold zasobu during lactation, it is necessary to translate the lack of speech into the use of sumishami.
Mindfulness from alcohol
People do not drink alcohol because of the possibility of strengthening the hepatotoxic effect of active components. The infusion of alcohol-based drinks during the first hour of rejoicing can lead to an important injury to the liver.
Interaction with medicines
The use of an anti-cold drug has a potential therapeutic effect and ethanolic drugs, MAO inhibitors, antiallergic and sedative drugs. Through the possibility of impaired intestinal motility, increased AT, stuttering of the sechovention, and inhibition of the functions of the sinuses, it is not necessary to move Coldact Flu Plus s:
- antipsychotics;
- antiparkinsonian methods;
- glucocorticosteroids;
- phenothiazine derivatives;
- uricosuric faces.
Tricyclics potentiate the vasoconstrictor activity of phenylephrine, resulting in the development of slunar arrhythmia. Therefore, before the selection of doctors, it is necessary to consult with a doctor.
Overdose
Take more than 10 capsules of Koldakta Flu Plus before overdosing with paracetamol, phenylephrine and chlorphenamine, manifested as:
- sleep disturbance;
- arrhythmia;
- zamorochennya;
- increased sweating;
- depression of the central nervous system;
- intestinal atony;
- decrease in arterial pressure;
- midriaz;
- sudomi;
- tremor;
- anxiety;
- drativity;
- hyperthermia;
- dryness of the mucus mouth;
- destruction of information;
- drowsiness.
In case of one-hour infusion of alcohol liquors or drunkenness, parenchyma damage occurs, which threatens with the development of hepatic encephalopathy and induces a lethal end. Also, patients are diagnosed with cardiological complications - hypertensive crisis, tachycardia, change in pulse rate.
Symptomatic treatment of overdose of bowel lavage and the intake of activated vugill. Cytostatic effects are observed in addition to parenteral administration of cysteamine or oral administration of methionine.
Pobichna diya
In 95% of patients, Coldact Flu Plus is well tolerated by patients of all age groups. Nebazhany efekti vykayut at times of overdose dosing or triple vikoristannya capsules. Most ill to complain about:
- oven;
- dry mouth;
- decrease in appetite;
- relax the void;
- bіl at epigastric;
- flatulence;
- hemolytic anemia;
- headaches;
- confusion of information;
- damaged orientation;
- noise in the ears;
- psychomotor arousal;
- sudomi;
- kropiv'yanu feverishness;
- disruption of accommodation;
- reflex bradycardia;
- Bronchospasm.
In case of dysfunction of nirok, aseptic pyuria is indicated, it is difficult to pass the secretion and liver kolki. Patients with cerebrovascular pathologies may suffer from an increased arterial pressure, buttocks, chest pains and arrhythmia. In times of hypersensitivity to active speech, toxic epidermal necrolysis, erythema multiforme, and spleen are diagnosed.
Contraindication to congestion
Combinations of the drug do not work in case of drug allergy to inactive and inactive components. Absolute contraindications before the recognition of capsules є:
- critocutaneous glaucoma;
- thyrotoxicosis;
- virazka shlanka;
- inflamed sich michur;
- nir's insufficiency;
- atherosclerosis;
- circulatory diabetes;
- Gilbert's syndrome;
- bronchial asthma;
- hypertensive illness.
Through the death of a sedative, the faces of the next person were wiped out from the water of the car and the work with traumatic possessions.
Analogues
You can replace Coldact Flu Plus with names from the same pharmacological group with a similar set of speeches that can be used:
- Extratab;
- Coldrex;
- AntiFlu;
- Fervex;
- Angisept;
- Coldfree;
- Vokasept;
- Antigripin.
Wash the sale and save
Anti-cold medications are sold in pharmacies without a prescription from an otolaryngologist. It is recommended to take the capsules from the dry and protected from light at a temperature of 15-25 degrees Celsius. The term of exclusivity from the moment of release becomes 24 months.
To the warehouse of the drug Koldakt include active ingredients - 0.5 g + chlorpheniramine maleate - 0.08 g of the additive speech to form a gelatin shell.
In warehouse Coldact Flu Plus capsules of intoxicating speeches: paracetamol - 0.2 g; - 8 mg; - 25 mg and additional speech ( hypromelose, MCC, talc, ethylcellulose, povidone, diethyl phthalate, barvniki, sucrose, water, sodium disulfite, starch syrup, disodium extract, zukrov grits).
Suspension Flu Plus revenge of active ingredients: chlorphenamine maleate - 2 mg; paracetamol - 0.125 g; phenylephrine hydrochloride - 5 mg+ sodium carmellose, propyl parahydroxybenzoate, disodium edatate, methyl parahydroxybenzoate, sodium saccharinate, sodium chloride, MCC, glycerin, sucrose, xanthus gum, silicon dioxide, flavors, polysorbate 20, sodium citrate, water, citric acid.
Release form
Koldakt release from capsules prolonged dії in shells made of gelatin, packs of 10 pieces.
Coldact Flu Plus- Do two forms:
- capsules in obolontsi with gelatin, half red, half transparent, middle - yellow, red and white pellets, in packs of 10-100 pieces;
- suspension for internal infusion, vyazka, orange, with a specific smell, in a bottle of 60 ml.
Pharmacological activity
Antihistamine diya sound judge. anti-congestive .
Flu Plus may also antipyretic і sickly dіyu.
Pharmacodynamics and pharmacokinetics
Go up to the tablet warehouse Koldaktі Coldact Plus chlorpheniramine є the biggest diєvim antihistamine use , which changes the inflow to H1 receptor . Also may be insignificant sedative і antimuscarinic effect. Speech can reduce the penetration of mucosal mucosal cells in the nose, thereby changing the unacceptable symptoms (sverbіzh and bloating).
The process of interaction with blood plasma seems to be correct. The maximum concentration is after 2-6 years, it is metabolized in the body. However, yoga is an insignificant part of being seen for help brunok.
Insha fluent speech - phenylpropanolamine є symptomatomimetic . Splashing on alpha-adrenergic receptors , but a lesser world, lower, for example,. May ship-sounding, anti-abryakov on the mucous membrane of the nose and paranasal sinuses.
Reach maximum concentration for 2 years. Vision is made through nirks.
Lowering body temperature and pain relief. It relieves the symptoms of a cold - headache, pain in the globules and m'yazah, unacceptable sensations in the throat.
With blood proteins it is bad, less than 10%, metabolized in the liver, max concentration - after 3 years. Vivendennya vіdbuvaєtsya іz szecheyu protyazh dobі pіslya priyomu.
Indication before zastosuvannya
- (vasomotor or allergic );
- usunennya such symptoms of a cold, like allergy, swelling, undead, hiccups .
Contraindication
Suspension can be taken by children from 6 years old.
Flu Plus may low additional contraindications:
- severe forms of ailment of nirok, liver, heart, zhovchny mіkhur;
Pobichna diya
I don't blame often.
- drowsiness, headache, overexcitation that zaiva dramativism;
- hepa- і nephrotoxic infusion;
- dryness in the mouth empty, drifting, boredom, loss of appetite ;
- promotion, problems out of the blue;
- bіl at the breasts, dysuria ;
- pain in epigastralny dilyantsі , loss of appetite.
Instructions for Koldakt (Method of dosing)
Trivality to accept that dosing is to blame for recognition of the doctor.
Zgidno z іnstruktsiєyu іz zastosuvannya Koldaktu, grown up prescribe 2 capsules per dose, divided into 2 doses.
Course likuvannya vіd 1-3 ( , ) up to 30 days.
Instructions for application Coldact Flu Plus
According to the instructions, Coldact Flu Plus is prescribed two capsules per doba, every other hour.
The syrup should be taken well before the treatment.
Let's grow up to prescribe 30-40 ml per day, for 3-4 doses. Children age six years old - 15-20 ml, for 3-4 doses.
The course of likuvannya, ring out, to become troch more than five days.
Overdose
Vipadki not registered. Therapy is good for symptoms.
For the form, before the warehouse to enter paracetamol, the symptoms are: nausea, hepatonecrosis , blіdіst that weakness, decreased appetite. Yaknaishvidshe turn to the doctor and promit the slug, enter donors SH-group , methionine (before 8 years) or N- (12:00).
Interaction
To protect victoriousness from the future MAO inhibitors, tricyclic antidepressants, halothane, guanethidine,