Modern pharmacological firms reveal the difference between pain-reducing and antipyretic diseases. Similar preparations, singsongly, in the skin home first aid kit. The stinks help the patients, they quickly get sick of the pain and the speck, as they can appear raptovo. Practice shows that one of the effective and demanding lyrics is "Nimesil". Instructions, instructions and description of the preparation will be given for your consideration. Also, you know how you can replace your zasib.
What is "Nimesil"?
Nimesil is a powder, which is produced by a German pharmacological company. At the yogi warehouse there is a medical speech nіmesulіd. The drug is packaged in sachets, the skin contains 100 mg of the main component and 2 grams in a single dose. Vyrobnik here vikoristovuyu additional storage: sucrose, citric acid, ketomacrogol, maltodextrin and orange flavor.
"Nimesil" - can be an analgesic and antipyretic drug. It is also the building's igniting process that proceeds in the body. The drugs are included in the list of non-steroidal anti-inflammatory drugs, which are sold without a prescription. Variety of 30 bags is about 700-800 rubles. Deyaki pharmacies sell sachets by the piece.
Virobnik about faces
The instructions say that “Nimesil” is a miraculous way to overcome pain caused by various reasons. The medication is congested if:
- hurt a tooth;
- blamed after surgery for minimally invasive interventions;
- the patient is diagnosed with arthritis or other pathologies of the musculoskeletal apparatus, which are accompanied by pain syndrome.
Faces are effectively used as a shelter, as they can be blamed for infectious diseases or for other reasons. Zastosuvannya powder "Nimesil" - tse way to use the ignition process, which proceeds in the swamps and soft tissues. Also, the medication is zastosovuєtsya with sudinnyh, gynecological and urological pathologies.
Contraindication to congestion
Before that, as a victorist of the faces of "Nimesil", the instruction from the zastosuvannya (discussing the advice about the tse) is due to be read respectfully. I would like to pay special attention to the next point, de umovleno contraindication. If you want to be able to do it one by one, then you should follow up with the medication. Powder "Nimesil" contraindications:
- with a high sensitivity of the patient's body to fluent speech or other components;
- virazkovyh razhennyah intestines chi slump;
- bleeding in the grass tract;
- vaginosti, shards can negatively penetrate into the її overflow and shaping of the fetus;
- breastfeeding through seamless penetration into milk;
- moving vice;
- Nirk deficiency.
The choice of words in pediatrics has been harrowed, as it is no longer considered a doctor individually.
"Nimesil": zastosuvannya
Advice about the drug rozpovidayut, scho dosing it is acceptable to take. The drug is implanted internally in a rare sight, it has a licorice relish and does not cry out. The instruction recommends vicoristing the faces only after that, the shards of speech can be negatively injected into the mucous membrane of the shell.
A single dose of the drug becomes 100 mg of nimesulide, which is more than one sachet. At the time of the hospital, a portion of liquor may be used. The additional norm for the drug is 200 mg, it can be changed independently.
Before taking it, it is necessary to prepare a medication. How to rozvest "Nimesil", the instruction of rozpovіdaє report. For which you need 250 ml of pure water. Sip the powder in a bowl and thoroughly mix. Drink only if the granules are spreading more. Do not save ready-made faces. Dilute a new dose before skin administration.
Effects of therapy
It is clear that the faces are positively injected into the body of a person who sees a decrease in elevated temperature and the development of a pain syndrome. The drug blocks the synthesis of prostaglandins in the inflammation of the fire. Pratsyuє zasіb schonaymenshe 6 years. Ale in deyakyh osіb medicine dіє іnakshe. Vіn viklikaє side reactions, yakі can turn into an attack:
- disruption of the robotic herbal system (stove, pain in the abdomen, diarrhea and constipation, boredom);
- vpliv on the central nervous system (confusion, headache, stomlyuvanity and drowsiness);
- allergy (shkirn_ hanging and sverbіzh,
- damage to the flow of water (faults, malfunctions in robots).
With the appearance of one or more of the descriptions of symptoms, it is necessary to indulge in repentance and turn for help to a medical mortgage.
Dodatkovі v_domosti about the drug
Virobnik rozpovidaє a lot of important information about the drug, as it is necessary to obov'yazkovo vrahuvat, so you choose to accept applications for:
- "Nimesil" for children of a young age is not assigned for everyday furnishings. The jubilation of pidlіtkіv can be zdіysnyuvatisya, but only if it is recognized as crushed by the doctor, with the improvement of coriste and rizikіv. In the skin situation, an individual dose of the drug is selected.
- Patients with duct-intestinal ailments in the anamnesis should be especially careful to beat the faces, shards of pathology can become aggravated. To reduce risk, it is necessary to take the minimum dose of the drug in a short course.
- Take the drug at your own warehouse for sucrose. It is necessary to give respect to patients who suffer from diabetes, fructose intolerance, or to individuals who are on a low-calorie diet.
- Do not follow Nimesil with other drugs of the NPZZ group.
- Medications that change blood pharynx, taken together with "Nimesil", strengthen their action.
Analogues
The drug can be replaced by similar methods based on nimesulide. You can choose the following faces:
- "Nimulid" - syrup, permissions for vikoristannya in children of all times;
- "Nise" - tablets containing 100 mg of oral speech in a skin tablet;
- "Nimesulid" - granules for the preparation of rosemary;
- "Nemulex" - granules, admissible to victoria in children from 12 years of age;
- "Aponil" - tablets of 100 mg;
- "Nimika" - tablets that are dispersible.
For whatever reason, Nimesil is not suitable for you, tablets can be selected based on other fluctuating speech. The most safe methods are drugs based on ibuprofen and paracetamol. Trade names of such drugs: "Kalpol", "Panadol", "Nurofen", "IBuklin" and so on. You can get them without a prescription practically at the skin pharmacy. You can replace the medicine "Nimesil" with the help of "Diklovit", "Ketorol", "Ketonal" and others. If you do not fit the application, turn to fakhivtsya for the selection of an alternative claim.
Nimesilє dosing with a serious drug, which should be taken less for the doctor's confession. However, practice shows that no one is insured in the form of a drug pardon, so if you are recognized for any drug, it is recommended that you independently respectfully read the instructions for something new before taking it. In this article, we will try to find out in the specifics of this medical problem, so that we can avoid negative consequences as a result of this zastosuvannya.
Warehouse of nimesil
Nimesil- tse synthetic medicinal preparation, the main intoxicating speech in yacomu - nimesulide. As additional speech in the new place: sucrose, citric acid, flavoring, maltodextrin, ketomacrogol 1000.
Nimesil is produced in powder form, packed in sachets of 2 g (9, 15 or 30 pieces per pack). One sachet contains 100 mg of fluffy speech.
Indication for stosuvannya Nimesil ta yoga diya
Nimesil can be a strong pain reliever, antipyretic, and also an antiseptic pharmacological drug. After receiving the internal speech, the nimesil is swept up by the duct-intestinal tract, split by the liver and carried out importantly through the nirks. For doba, the drug is excreted by 98%, and in case of drought, it does not accumulate in the body. The trivality of the nemesil is about 8 years old.
Nimesil is prescribed for such cases:
- hostile pain syndrome;
- post-traumatic pain;
- fuses, which are accompanied by a rise in body temperature;
- pain syndrome in the postoperative period;
- disease of the musculoskeletal apparatus (osteoarthritis, rheumatoid arthritis, tendonitis);
- myalgia;
- bіl and igniting processes in case of gynecological diseases;
- іnfektsiyno-zapalnі zahvoryuvannya іn.
Nimesil for toothache
Nimesil can be used to relieve a pain symptom and to relieve the progression of the ignition process in case of caries, illness is clear and other processes that cause dental pain. However, varto understand that the main meta of the drug to be taken is to reduce hostility. Tobto in the investigation of the main cause, which caused the pain syndrome to be blamed, I do not take part in it, but rather temporally suffer the symptoms of illness.
Method of stosing Nimesil
Nimesil was used as a powder for internal infusion of vicorous to prepare a suspension. For this slid visipati instead of a sachet in a bottle (250 ml) stir the container thoroughly.
The drug should be stopped only after a dose of 100 mg of two per doba (medium dosing). The interval between taking a single dose is 12 years. At the time of consumption, the dose of the drug can be increased, reducing the severity of the disease and the effectiveness of the drug in a particular mood. The drug can be ingested no more than 15 decibels. Likuvannya nemesilom trace, as if there is no positive clinical effect in the form of yoga.
Contraindication before taking Nimesil
The drug is prescribed for older adults, as well as for children of 12 years of age, to improve the assessment of corystitis and shkodia to the drug (risik). 
Nimesil contraindications for pregnancy, as well as for the first hour of breastfeeding, tk. you can kill the original shkodi of the fetus and the child. Just as this medicinal charge is prescribed during the period of breastfeeding, it should be prescribed during the period of resurrection.
One of the ways to choose for the treatment of acute pain syndrome is "Nimesil" powder. This drug may have a good short-term effect, prote unsafe potential for many side effects. The best recommendation in the future will be in the form of independent recognition of strong-living diseases.
The sachet has dry granules for preparing a suspension. I'll give you a taste of drink for a rahunok of orange flavor, salty juice and citric acid. To improve the structure of the suspension, a macrogol polymer and maltodextrin are added to the powder.
The main active ingredient is speech nimesulide. Portion, prepared from one sachet, contains 0.1 g of each component.
Pharmacological power and indication before zastosuvannya
In response to nutrition, which helps "Nimesil", it should be said once again that the wine does not have a juicy effect - the suspension is drunk as an anesthetic.
Vaughn znimaє vіdchuttya with such camps:
- snowy white;
- bіl pіd hour of the menstrual cycle;
- gostrі m'yazovі bolі, among that number after traumas and stretching;
- pain syndrome due to inflammation of the teeth is clear.
Chinny component blocking receptors, sensitive to pain mediators.
As a result, when finding information in the intercellular space of ignition agents, nerve endings simply cease to receive them. The hosts noticeably take notice, and step by step they listen.
In addition, the same component in the other direction - reduces the vibration of speeches, which are established under the hour of incendiary. Later, it subsides like a pain syndrome, and blackness, swelling, swelling of tissues pass.
I will accept
Powder for ingestion is administered to children up to twelve years of age due to its high toxicity.
Nimesil powder: instructions from the application.
Tsya speech is brought to the strong. Incorrect dosing may result in far-reaching negative consequences. You can change the mood of the current unacceptable reactions to the fluctuations of the short-livedness of the reception.
How to breed Nimesil powder
The granules are best grown in warm water. They place them near the flask and fill it with a hundred milliliters of rindine. They don’t save preparations, but live overnight.
Dosing mode
Vmіst one package vikorivuyut once. Tse is a standard one-time norm. Usim, starting from the twelve-year century, the same dosing is prescribed.
As much as possible, you can take "Nimesil" for a quantity of no more than two bags. The course of likuvannya can be revisited for twelve days.
In order to avoid the vindication of side effects, it is necessary to try as much as possible to speed up the recovery of the drug and the survival of the whole exaltation.
Features
- Under the hour of thriving zastosuvannya the preparation followed the steps behind the camp with a picture of blood.
- In those with ill-healthy PCT, it is possible to develop problems against the background of admission. At the first appearances, a sign of intoxication and a herbal discord will soon appear in the distant exaltation.
- Patients with impaired liver function require an individual correction of the norm. For the osіb frail age such visits are not passed.
Vzhivannya їzhi do not spill onto the steps of the smoky active speech. Ale, in order to hide away from the side of the grass path, I have prepared a suspension to drink after the hedgehog.
In practice, there was a tendency to a sharp decline in the dawn and a natomist rejoicing. For any problems, it is good to take the next powder.
As a rule, the temperature of the body rises during the hour of treatment, or it blames respiratory infections in the form of a distant substitution of the drug, varto recovery.
Medical interaction with other drugs
- Fluent speech often suppresses platelets and blood circulation. Yoga zastosuvannya is contraindicated with one-hour administration of preparations, which will achieve that very function. The damage to the cih could threaten the appearance of internal bleeding.
- Building powder reduces the effectiveness of diuretics and the transfer of salts to the body.
- Faces potentiate the toxicity of antibiotics and antitumor drugs. Їx one-hour reception ruinіvno diє pіchіnku. Z tієї Well, the reason for the suspension is not the sum of alcohol.
- With an one-hour vzhivannі powder and sudorozshiryuvalnyh zabіv, scho reduce the pressure, enzymes can accumulate, which reduce the activity of nirok. As a result, as a side effect, nir's deficiency develops.
- Common speech is associated with anti-diabetic drugs. To that, their sleep is unacceptable.
Contraindications, side effects
The analyzed drug has a significant contraindication.
Yogo zastosuvannya skasovuetsya, as in the past and the present patient, they will either be saved:
- fuses infesting the herbal tract, aggravated with virazki, erosions, rupture of the wall, bleeding;
- serious damage to the robotic visual system;
- pathological conditions of the liver;
- nasty susceptibility of non-steroidal anti-pain drugs;
- poisoning with aspirin;
- allergy to other antiseptic drugs;
- pathology of the hematopoietic system with impaired larynx;
- be it polynosis, sinusitis, respiratory disease;
- fever;
- body temperature, which airs in the normal state;
- promptly vtruchannya at the robot's heart and vessel;
- hypertension, cerebrodiabetes after another type;
- vagіtnіst that period of the year.
Let's consider a number of contra-indications for the following signs of alcoholism and smoking. The drug may have a strong injection on the liver. Vіn is not guilty of confessing to them, who had the same organ in the past, having recognized chemical destruction.
Among the reactions to speech are guarded:
- allergies, dermatitis of various degrees of severity up to tissue destruction;
- impaired blood picture with a sharp decrease in the number of red blood cells and increased signs of inflammation and allergic reactions;
- lowering the visitation of dawn;
- change the heart of a robot with a broken rhythm, a change of bloody vice;
- nervous attacks, confusion, decrease in productivity, brain damage, fear at night;
- discord dihannya;
- severely unwell;
- zagostrennya intestinal ailments;
- zatrymka virobitka section;
- weakened functions of the liver and nirok;
This change does not include individual reactions to the drug.
Before analogs of suspensions, preparations are considered:
- "Aponil";
- "Nise";
- "Nimegezik";
- "Nimesulid";
- "Nimid";
- "Nimulid".
Basically, analogues are the preparations of the Indian campaign, which, for the price, win against the powder that is being looked at. All the faces on the list think one and the same fluent speech, that stench can follow the instructions how to stop. Dozuyut faces for one principle.
- "Aponil" is vibrating in Cyprus. Maє likarsku form pіgulok. In one preparation 100 mg of fluffy speech. Like all faces of this series, you are admitted for the doctor's prescription.
- "Nise" viroblyayetsya in tablets half and full doses. It is also produced as a standard 1% gel. In the case of the gel, it is necessary not to exceed the admissible ten-day course of treatment. In this form, the preparation can be applied only on the skin of the skin.
- "Nimegezik" - the suspension is ready with the aroma of steegla dino. Zastosovuєtsya have mature. One-time norm - two kovpachki. The bottle contains 60 ml of lye.
- "Nimesulid" - tablets 100 mg. Rarely sold in pharmacies like a gel. Zastosovuєtsya similarly from "Nise".
- "Nimid" - zasіb іndіyskogo pozhennja v vyglyadі sachetsіv-sashі i zovn_shny gel. The dosing and method of implantation is exactly the same as in similar preparations.
- "Nimulid" - Indian analogue. Zustrichaєtsya in tablets, in looking like a sour gel that ready-made suspension. Previously, it was recommended to children as the most powerful antipyretic. Pіznіshe z'yasuvalosya, scho priyom not summіsny іz high temperature.
Narazi all preparations on the basis of such a fluffy speech fence before being recognized for children up to 12 years of age.
A glanced powder can clearly show the pain-killing power. Notes about yoga zastosuvannya are more importantly positive. Ale, don’t forget the warto, which zasіb greatly complicates the work of the liver. To that, if possible, the next uniqueness of trival glee.
Nimesil is a drug that is often prescribed in modern medicine, which can have an antispasmodic and analgesic effect on the body. Unfortunately, a human being is not insured against medical pardons.
Therefore, it is necessary to independently read the instructions to the preparation before yoga application. Such a preventive approach will help to eliminate the blame for negative consequences for the recipient.
What are the components to enter the warehouse of the drug, its pharmacological power
The release form of Nimesil is a powder, which is vicarious for preparing a suspension. The color of the powder is light yellow. The drug has an orange smell and is available in 9, 15 or 30 sachets per pack.
Nimesulide (100 mg total) is applied to the skin sachet of the medicinal product. Additional speeches are: maltodextrin, sucrose, ketomacrogol 1000, orange flavor, anhydrous citric acid.
Zasіb maє protizapalnu diyu, as well as analgesic and antipyretic. As soon as it enters the body, the components of Nimesil are soaked through the intestinal tract.
The maximum concentration of liquids in the blood is observed after 3 years after taking yoga. The preparation of the components of the medicinal product for the body is monitored after 4-6 years. Outside the sight of likiv vіdbuvaєtsya for help brunok.
In some cases it is allowed, and in some it is forbidden to take faces
The main indications before taking the drug Nimesil є:
The preparation vikoristovuyut for usunennya pain, scho raptovo vinik, and for trivalo therapy of sickness. Krіm such a great change of indication, іsnuyet і protipozannya. Before these you can see:
- vaginess that period of breastfeeding;
- manifest pathology of the mucous membranes of the intestinal tract;
- skhilnist to bleeding and thrombosis;
- bronchial asthma;
- often spozhivannya alcoholic drinks;
- Intolerance to the components of the drug.
How to breed Nimesil powder and drink properly
How to take faces correctly? For the treatment of unacceptable symptoms, the powder is usually taken 1 sachet 2 times a day. Promіzhok mizh priyomami is not guilty but less than 8 years.
The optimal amount of additional liquid intake is 200 mg. Likewise, the drug vicorist is used in the first day of viral infection or the post-operative period, dosing can be increased up to 300 mg.
What is the correct way to breed a medical zasib? The powder from the sachet must be poured into a cup with a volume of 200 ml (or a bottle) and poured with warm boiled water.
Zasіb prepare less for the need to live. It is not recommended to save the diluted suspension.
To reduce the risk of such an illness, such as gastritis, as well as to prevent bleeding in the sac, it is necessary to take more than once.
Instructions for congestion for children, as well as for pregnancy and lactation
Faces are allowed to be taken by children, starting from 12 years and less for the recognition of the doctor. Yakshto bіl, scho wine among children, tolerant and not to have a hostile character, more likely to go to the people's zasobіv. For example, for a not high temperature, you can drink linden tea with honey and raspberries.
How to take Nimesil powder for pregnancy and lactation? Vidpovidno to instructions, non-steroidal anti-spasm can negatively affect the body as a vagit woman, as well as the fetus that is in the womb.
Possibly impaired functioning of the nerves, the development of such complications, such as chronic hypertension, bleeding, peripheral swelling.
For these reasons, Nimesil is not recommended to be used in cases of pregnancy during breastfeeding, shards of this component penetrate breast milk. In a vignette mood, it is possible to stagnate faces, as if potential melancholy for the mother outweighs the possibility of harm to the fetus.
In such cases, a minimal dose is prescribed for a short period of time.
Side effects and signs of overdose
Side effects of the drug taken are often blamed for overdose: 
- in the organs of the herbal tract: pain syndrome, vomiting, nausea, diarrhea and constipation;
- in the nervous system: sleep disturbance, migraine, apathy to the mindless people, confusion, anxiety syndrome;
- in the cardiovascular system and blood: frequent heartbeat, thrush, anemia;
- in the organs of the dichal system: inconsistency, bronchospasm;
- on the skin of the curve: hanging, verably syndrome, dermatitis, signs of kropivyanki;
- less often there is a development of nirk deficiency, nephritis, dysuria.
Of the side effects of varto, we can see an increase in fever, severe illness, asthenia, impaired zonal function, and an increase in potassium in the bloodstream. In order to blame similar symptoms, it is recommended to refrain from stosuvanniya Nimesil and tell the doctor about them.
Concomitant injection of other drugs
It was harrowed with the help of Nimesil and acetylsalicylic acid in order to stop bleeding.
When impossibility to escape such a concurrent stagnation of the lips, it is necessary to systematically control the state of the function of blood glottis.
With special respect, it is recommended to take Nimesil and Methotrexate. A break between priyomami koshtiv can be not less for the booty. In the other case, the methotrexate rіven in the blood rises, and also increases its toxicity. If you take Cyclosporine with Nimesil, the nephrotoxicity of the rest also increases.
Average price for the drug in Russia and Ukraine
In the places of Russia, the average variability of the drug is no more than 500-600 krb. per pack (30 packs). How to buy by the piece, one bag will cost an average of 25-35 rubles.
In places of Ukraine, the average price of one package is 9 UAH. Packing for 30 bags costs approximately 200-250 UAH.
- A drug that belongs to the group of non-hormonal (non-steroidal) anti-inflammatory drugs. Yogo active speech є nіmesulіd, yak, like іnshі likі ієї grupi, fight іz inflamed, lower body temperature, znimaє bіl.
For the effectiveness of Nimesil, it can be reversed or reversed by such other drugs, for example, Diclofenac, Ibuprofen. All the faces of this series may exert a strain on the systemic diarrhoea, the proteus zasib significantly less inflows into the camp of the intestinal tract of the sick person. Nimesil to carry out healing, like grown-ups, and young patients, with feverish camps, infectious and rheumatic lesions, pains, and crippling injuries.
Installation instructions
Pharmacological authorities
Pharmacodynamics
Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) from the sulfonamide class. Repair anti-spasmodic, anti-painful and antipyretic medicine. Nimesulide acts as an inhibitor of the cyclooxygenase enzyme, which acts for the synthesis of prostaglandins and inhibits, smut, cyclooxygenase 2.
Pharmacokinetics
After taking the drug internally, it is well absorbed from the intestinal tract, reaching the maximum plasma concentration in 2-3 years; binding from plasma proteins - 97.5%; the period of drinking becomes 3.2-6 years. Easily penetrates crisstohematic barriers.
Metabolized in the liver for the help of cytochrome P450 (CYP) 2C9 isoenzyme. The main metabolite of the pharmacologically active parahydroxide nimesulide is hydroxinimesulide. Hydroxymesulide appears to be alive in the metabolized species (appears exclusively in the species glucuronate - about 29%).
Nimesulide is administered to the body, most importantly by drugs (about 50% of the administered dose). The pharmacokinetic profile of nimesulide in patients with a frail age does not change with the admission of single and bacterial/repeated doses.
According to the data of the experimental study, which was carried out for the participation of patients with mild and mild stage of nirk insufficiency (creatinine clearance 30-80 ml/min) and healthy volunteers, the maximum concentration of nimesulide and iodine metabolite in the plasma of patients was not overestimated the concentration of nimesulide in healthy volunteers. The area under the curve "concentration-hour" (AUC) and the period of drug administration in patients with nirkovoy insufficiency were higher by 50%, but in the range of pharmacokinetic values. With repeated administration of the drug, there is no cumulation.
Indication for zastosuvannya.
Exaltation of acute pain:
- pain syndrome in the cystic-mucosal system;
- traumas, stretching of ligaments and twisted joints;
- tedenity, bursitis;
- dental white;
- symptomatic relief of osteoarthritis with pain syndrome;
- algomenorrhea.
The drug is indicated for symptomatic therapy, reduction of pain and inflammation at the time of healing.
Method of stosuvannya that dose
Promotions (from 12 to 18 rokiv)
On the basis of the pharmacokinetic profile and pharmacodynamic characteristics, there is no need for dose adjustment in patients.
Patients with impaired nirok function
On the basis of pharmacokinetic data, there is no need to adjust the dose in patients with mild and moderate forms of nirk deficiency (creatinine clearance 30-80 ml / min).
Patients of a frail age
When treating patients of a frail age, the need to adjust the additional dose is determined by the physician who is able to interact with other medical procedures.
Features
Negligible side effects can be minimized at the lowest effective dose of the drug with the least possible short course.
Nimesil should be used to protect patients with mucosal-intestinal ailments in history (virazkovy colitis, Crohn's ailment), stools may be aggravated by these ailments.
The risk of schluno-intestinal bleeding, more than one perforation or more perforation is associated with an increase in the dose of non-steroidal anti-inflammatory diseases in patients with the presence of a history of the disease, especially aggravated bleeding or other tests clothes, as well as in old patients, this should be started with the lowest possible dose.
In patients, if there are medications that reduce blood pharynx or inhibit platelet aggregation, there is also a risk of slug-intestinal bleeding.
In cases of slunic-intestinal bleeding, or in patients, if they take Nimesil, treatment with the drug should be taken. Oskіlki Nimesil is often administered with nirks, dosing for patients with impaired functions, the next change, fallow in the form of a cross-section.
Є data about the blame for single fluctuations in reactions from the side of the liver. If a sign of liver damage appears (skinny sverbіzh, pozhovtinnya skіrnіkh kinkіv, nudity, vomitting, pain in the abdomen, darkening of the sciatica, increased activity of "liver" transaminases) should be taken with the drug and taken to the doctor.
Irrespective of the severity of the damage to the eyes of the patients, if they took nimesulide at the same time with other non-steroidal anti-spasmodic methods, the treatment may be negligently attached. As if there is damage to the dawn, the patient is to blame for the care of the doctor-ophthalmologist.
The drug can cause stippling of the radii in tissues, to patients with high arterial pressure and impaired cardiac activity, Nimesil should be treated with special care.
In patients with nirk or heart failure, the drug Nimesil should be used as a precautionary measure, as a result of which the function of niro can be impaired. In times of illness, I will be treated with the drug Nimesil, it is necessary to take it.
Clinical studies and epidemiological data allow the growth of visnovs about those who have non-steroidal anti-inflammatory diseases, especially at high doses and with a trivial congestion, can lead to an insignificant risk of myocardial infarction or stroke. For zabіgannya rizik vyniknennya such podіy with zastosuvannі nіmesulіdu given is not enough.
Before the warehouse, the drug should include sucrose, which is recommended for patients who suffer from cerebrovascular diabetes (0.15-0.18 XE per 100 mg of the drug) and for individuals who are on a low-calorie diet. Nimesil is not recommended for patients with rare relapsed fructose intolerance, glucose-galactose malabsorption, or sucrose-isomaltose deficiency.
In case of a symptom of a cold or acute respiratory viral infection in the process of treatment with the drug Nimesil®, the drug is due to injections.
Do not follow Nimesil at once with other non-steroidal anti-inflammatory measures.
Nimesulide can change the power of platelets, which should be protected when the drug is taken in patients with hemorrhagic diathesis, but the drug does not replace the prophylactic disease of acetylsalicylic acid in cardiovascular disease.
Year-old patients are especially susceptible to unacceptable reactions to non-steroidal anti-inflammatory diseases, including risky mucosal-intestinal bleeding and perforation, which threaten the patient's life, impaired function of the veins, livers and hearts. When taking the drug Nimesil for this category of patients, an overarching clinical control is required.
As well as other drugs of the class of non-steroidal anti-inflammatory drugs, as they inhibit the synthesis of prostaglandins, nimesulide can negatively affect the overshoot of vagity and / or on the development of the embryo and can lead to an hourly occlusion of the arterial duct, hypertension in the system of the legenous artery, impaired function of the nirok, as you can go to Nirk deficiency. with oligohydramnios, to increase the risk of bleeding, decrease in uterine contractility, and cause peripheral swelling.
At the link with cym, nimesulide contraindications for the first hour of pregnancy during lactation. The use of the drug Nimesil can negatively affect women's fertility and is not recommended for women who plan to become pregnant. When planning vagity, a consultation with a doctor is necessary.
There are data on viniknennya in okremi types of skin reactions (such as exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis) to nimesulide as well as to other non-steroidal anti-inflammatory diseases. With the first signs of visipu on the skin, lesions of the mucous membranes, or other signs of an allergic reaction, taking the drug Nimesil slid should be administered.
Injection into the building to keruvannya by road
Having injected the drug Nimesil into the hospital before caring for motor transport and the control of the mechanisms did not work, then during the period of treatment with the drug Nimesil it should be safe when caring for motor transport and engaging in potentially unsafe types of activities, which may increase the concentration ї respect and speed of psychomotor reactions.
Pobichna diya
Damage to the side of the circulatory and lymphatic systems
Allergic reactions
Damage from the side of the central nervous system
Damaged from the side of the organs
Destruction from the side of the dichal system
Destruction from the side of the intestinal tract
Damage from the side of the liver and zhovchovivіdnoї system
Damage from the side of the nirok and the sciatic system
Burning damage
Interaction with other medical care
Glucocorticosteroids: reduce the risk of bleeding from the slug-intestinal tract or bleeding.
Antiplatelet and selective serotonin reuptake inhibitors (SSRIs), e.g. fluoxetine: increase the risk of gastrointestinal bleeding.
Anticoagulants: Non-steroidal anticoagulants may be used as a substitute for anticoagulants such as warfarin. Due to the risk of bleeding, this combination is not recommended and is contraindicated in patients with severe coagulation disorders. Even though combined therapy still cannot be eliminated, it is necessary to carry out a detailed control of indications of blood clotting.
Diuretics: Non-steroidal antiseizure drugs may reduce the effect of diuretics.
In healthy volunteers, nimesulide timchasovially reduces the sodium excretion of furosemide, less the world - potassium excretion, and the lowering of the water diuretic effect.
Co-administration of nimesulide and furosemide resulted in a change (approximately 20%) in the area under the Concentration-Hour (AUC) curve and a decrease in cumulative excretion of furosemide without changing the clearance of furosemide.
Definitely administering furosemide and nimesulide will require caution in patients with impaired cardiac or cardiac function.
ACE inhibitors and angiotensin II receptor antagonists:
Non-steroidal antihypertensive drugs may reduce the dose of antihypertensive drugs. In patients with mild to moderate stages of nirk deficiency (creatinine clearance 30–80 ml/min) with total recognition of ACE inhibitors, angiotensin II receptor antagonists, or , antiaggregants), you can go further away. insufficiency, which, as a rule, is reversed.
Interactions should be considered in patients, if Nimesil is used in combination with ACE inhibitors or angiotensin II receptor antagonists. Therefore, the use of these drugs should be considered to be protective, especially for patients of a frail age. Patients are guilty of taking a sufficient amount of blood, and their function should be carefully controlled after the beginning of sleep therapy.
There are data about those that non-steroidal anti-inflammatory drugs change the clearance of lithium, which can lead to an increase in the concentration of lithium in the blood plasma and yogo toxicity. When nimesulide is prescribed to patients who are on therapy with lithium preparations, regular monitoring of plasma lithium concentrations should be carried out.
Clinically significant interactions with glibenclamide, theophylline, digoxin, cimetidine and antacid drugs (for example, a combination of aluminum and magnesium hydroxides) have not been reported.
Nimesulide inhibits the activity of the CYP2C9 isoenzyme. With one-hour administration of drugs with nimesulide, as substrates of this enzyme, the concentration of these drugs in plasma may increase.
If nimesulide is recognized less than 24 years before or after taking methotrexate, it is necessary to be careful, but in such cases, plasma levels of methotrexate may be significant, toxic effects of this drug may be increased.
In connection with the action on nirkov prostaglandins, inhibitors of prostaglandin synthetase, up to which nimesulide is present, may increase the nephrotoxicity of cyclosporins.
In vitro studies have shown that nimesulide is associated with tolbutamide, salicylic acid, and valproic acid. Irrespective of those that these interactions were indicated in plasma, no effects were observed in the process of clinical administration of the drug.
Contraindication
| Increased sensitivity to nimesulide or one of the components of the drug. |
| Hyperergic reactions (in history), for example, bronchospasm, rhinitis, kropivyanka, associated with the use of acetylsalicylic acid or other non-steroidal antiseptic drugs, including nimesulide. |
| Hepatotoxic reactions to nimesulide (history). |
| Complementary (single-hour) administration of medicinal drugs with potential hepatotoxicity, for example, paracetamol or other analgesic or non-steroidal antiseptic drugs. |
| Inflammatory bowel disease (Crohn's ailment, non-specific viral colitis) in the acute phase. |
| The period after coronary artery bypass grafting. |
| Fever syndrome with colds and colds of respiratory viral infections. |
| Outwardly or not laterally, bronchial asthma, recurrent nasal polyposis or paranasal sinuses with intolerance to acetylsalicylic acid and other non-steroidal anti-inflammatory diseases (including history); |
| Virazkov's ailment of the duodenum or duodenum in the phase of acute, the presence in the anamnesis of viraz, perforation and bleeding in the intestinal tract. |
| A history of cerebrovascular bleeding and other bleeding, and sickness, which are accompanied by bleeding. |
| Severe damage to blood clotting. |
| Severe heart failure. |
| Severe nirk deficiency (creatinine clearance 30 ml/min), confirmed hyperkalemia. |
| Pechinkov's insufficiency chi be-yak actively infecting the liver. |
| Children up to 12 years old. |
| Vagity and lactation period. |
| Alcoholism, drug addiction. |
With care:
- severe forms of arterial hypertension, type 2 diabetes;
- heart failure;
- ischemic heart disease;
- cerebrovascular disease;
- dyslipidemia/hyperlipidemia;
- disease of the peripheral arteries;
- chicken;
- creatinine clearance less than 60 ml/min.
Anamnestic data about the presence of a viral infection of CT, infection caused by Helicobacter pylori; summer vіk; trivale in front of vikoristannya NPZP; severe somatic illness.
Complementary therapy with offensive drugs:
The decision about the recognition of the drug Nimesil may be grounded on an individual assessment of "risk-corrosion" when taking the drug.
Overdose
Symptoms
- apathy;
- drowsiness;
- boredom;
- vomiting;
- bіl in the epigastric dilyantsі.
During the treatment of gastropathy, the symptoms of werewolves sound. May be blamed for slough-intestinal bleeding. In lonely depressions, there may be an increase in arterial pressure, acute insufficiency, respiratory depression and coma, anaphylactoid reactions.
Celebration
Questions and answers on the topic "Nimesil"
| I have a child on breastfeeding, and I took three days of Nemesil for toothache, I only read at once that yoga is categorically not possible with breastfeeding. I even boast about my daughter, her style has changed, becoming a marvelous pungent smell. I didn’t think that this drug was a contraindication, that yoga was prescribed in a canopy house after a caesarean roset, but I didn’t even start taking yoga. Tell me, be kind, now I need to show the child to the pediatrician? How can you have a legacy? |
| So, you need to go to the pediatrician, take a coprogram, feces for dysbacteriosis. It’s better for everything, the microflora just collapsed, it’s easy to correct with probiotics (bifiform, linex). |
| At what water did Nimesil develop? |
| The sachet is opened in pіvsklyantsі boiled water (100 g), but not hot. |
| What is the summіsny nіmesiv with alcohol? |
| Nimesil and alcohol cannot be consumed. Enzymes, which enter the warehouse of the drug, split and ethanol. With one-hour consumption of Nimesil and alcohol in the body, they have a great effect on their metabolism, which leads to an attack on the liver. Increased hepatotoxicity of Nimesil. A possible development of important conditions, right up to the liver Komi. In addition, with one-hour stagnation of Nimesul and alcohol, the drug can lead to a non-overdose: otherwise, it will not cause a significant effect, or it will increase the overall toxicity and risk of developing overdose effects. |