Your attention is invited to the instruction in Russian for the drug Sofosbuvir. Here are the instructions for the use of the drug Sofosbuvir and there is its price.
This drug is a direct antiviral inhibitor of NS5B RNA polymerase that inhibits the spread of the hepatitis C virus.
The active substance is aimed at stopping the multiplication of the hepatitis C virus. It is used to treat 1-4 genotypes of hepatitis C, but this is not a monotherapy drug, and each genotype has its own combinations with other drugs. In the case of the first and fourth, a joint course with Peginterferon and Ribavirin is recommended, for the second and third - a combined treatment with Ribavirin. The use of Sofosbuvir may vary depending on the presence of cirrhosis of the liver and on the response to past therapy.
Application of Sofosbuvir
The drug is used for the treatment of chronic hepatitis C in conjunction with other antiviral agents. How to take Sofosbuvir? This medication is recommended to be taken every 24 hours, orally, during meals, with plenty of water. The dosage is 400mg per tablet.
Sofosbuvir: side effects
Sofosbuvir has practically no side effects... Tests have shown that almost the only side effects of Sofosbuvir are fatigue, headache and nausea. However, when combined with other drugs, in particular with Interferon, the intensity of discomfort may increase. During your appointment, you should keep your hepatologist informed about how you are feeling. We would like to note that the medication does not affect the work of the cardiovascular system.
Sofosbuvir: contraindications
Sofosbuvir has minor contraindications. It is prohibited for use by the following groups of people due to the lack of drug tests for these groups:
- Individuals under 18;
- Pregnant women and women during lactation;
- Individuals who have hypersensitivity to the active substance;
- Fertile women should consult a doctor before starting drug treatment, since there is no information about the effect of the drug on reproductive functions;
- Patients with renal or hepatic insufficiency, especially the elderly, should be under the supervision of a physician for the entire course of treatment.
Interaction with other medicinal products
It should be taken together with other antiviral drugs only if the effectiveness of Sofosbuvir significantly exceeds the possible side effects. Attention: the combined use of the drug with Boceprevir or Telaprevir is highly undesirable.
special instructions
- The therapy takes place under the supervision of your doctor;
- We recommend a complex reception together with other drugs;
- Monotherapy is not desirable;
- 1 tablet is 400 mg of active ingredient, this is the recommended daily dose;
- It is not recommended to reduce the daily rate;
- The tablet must be swallowed whole, without chewing, washed down with plenty of water during meals;
- If there was vomiting within 2 hours after administration, a second dose is required;
- If you miss a dose of the drug, drink it as soon as possible, the next dose should take place at the usual time.
- During therapy, we strongly recommend that you refrain from work that requires high concentration and increased alertness.
Release form
Oval pills. The dosage is 400 mg. The package contains 28 pills.
Storage conditions
The medicine should be stored at a temperature of 15-30 ° C, in a dry place out of the reach of children. Avoid direct sunlight. The production date and shelf life are indicated on the packaging. It is strictly forbidden to take the medication after the expiration date.
Composition
The pill consists of 400 mg Sofosbuvir. The international name of the drug is Hepcinat.
Pharmaceutical company Natco Pharma, Ltd. Co. Manufactured under license from Gilead. Country of origin - India.
Note! On this page, only a simplified and complete instruction for the drug Hepcinat. We do not recommend that you self-medicate. Before taking the drug, consult a specialist.
It is from us that you can buy Sofosbuvir from India at the best price.
Sofosbuvir for the treatment of chronic hepatitis C
Brand name of the drug:Hepcinat
Contains: Sofosbuvir
Manufacturer: Natco Pharma Ltd.
Manufacturer country: India
Packaging: 400mg (28 tablets)
Sofosbuvir is a highly effective drug developed by the Indian pharmaceutical company Natco Pharma. The drug is an active generic. The product is produced with the help of high technologies and in compliance with the most necessary requirements and medical standards for drug production. By itself, the treatment with this drug is used in complex therapy of an interferon-free nature. A huge number of leading medical institutions with a worldwide reputation use this drug in the treatment of hepatitis C due to its high antiviral properties. Sofosbuvir has passed all the necessary clinical trials and is absolutely safe to use. The effectiveness of the impact on the hepatitis I virus is ninety-four percent. Often, for greater efficiency, doctors prescribe the use of Sofosbuvir in combination with Daklatasvir. It is believed that these drugs are most effective in the treatment of hepatitis C. According to statistics, excellent indicators in the treatment of hepatitis C were achieved even by patients with the third genotype of viral hepatitis. The only problem is that these unique generics are very difficult to acquire, especially in our country. They are simply not on sale in Moldova. But you can buy Sofosbuvir directly from us by placing an order on our website. At the same time, you can be absolutely sure of the quality of the purchased drug. The price for this generic on our website is reasonable. See for yourself the excellent healing characteristics of Sofosbuvir by reading the positive patient reviews.
Instructions for use of the drug Sofosbuvir
The drug is an inhibitor of the hepatitis C virus polymerase. The drug inhibits the replication of the virus in the human body, and therefore it can be used to treat hepatitis C both in combination with other drugs and alone as a main component. Clinical trials of Cofosbuvir have shown high efficiency in the treatment of the first, second, third, fourth genotypes of viral hepatitis C. There are no objective data on the effectiveness of the drug in the treatment of patients with HIV infection and hepatitis C.
The main indications for the use of Sofosbuvir
The drug is officially approved for use in combination with antiviral drugs for the treatment of hepatitis C genotypes 1,2,3,4 in adult patients. It should be used once a day, one tablet (standard dosage is 400 mg). The tablet should not be chewed as it tastes bitter. The drug should be used during meals, it is necessary to hammer the tablet with plenty of water. In order for the drug to suppress the replication of the hepatitis C virus, it is necessary to take the drug strictly at the same time.
Side effects
If we talk about the side effects of Sofosbuvir, then there are practically none. The medicine is very well tolerated by patients. There are no pronounced side effects characteristic of other antiviral agents. The most common side effects are nausea, headaches, and feeling tired. Side effects tend to increase with the combination of Sofosbuvir and interferon, or with the joint use of Sofosbuvir with other antiviral drugs. The medicine has the following contraindications for use:
Children's age (not applicable to adolescents and children under eighteen years old);
Pregnancy and lactation;
With increased sensitivity to medicinal components;
The use of children, pregnant and lactating women, persons with hypersensitivity to the drug components is not recommended, since clinical trials for these groups have not been conducted. With extreme caution, the use of the drug for women of childbearing age is prescribed, since the degree of influence on the reproductive functions of a woman has not been clinically established.
If we talk about elderly patients and people with kidney and liver diseases, then they should use the remedy under the supervision of their doctor. Do not combine the medicine with antiviral drugs such as Telaprevir or Boceprevir.
If we talk about special instructions, then they boil down to careful medical supervision of the drug intake system. The doctor can prescribe and select combination antiretroviral therapy. Monotherapy is possible, but still not recommended for patients with hepatitis C. A single dose is equal to one tablet right during the meal, you should not reduce the dose, you do not need to chew the medicine. A couple of hours after taking the drug, vomiting may occur, in which case you should take a second pill. Do not break the drug intake regimen. The medicine is available in blisters of twenty-eight tablets in one package, the dosage is standard (400 milligrams). The drug should be stored in a dark and dry place at a temperature of fifteen to thirty degrees. The shelf life and date of manufacture of the drug are indicated on the generic packaging.
The drug is used to treat chronic hepatitis C in adults in combination with other medications.
Clinical data on the use of sofosbuvir in patients with genotype 5 or 6 are limited.
There are no data on the effectiveness of the drug in patients with co-infection with hepatitis and HIV.
Contraindications
Hypersensitivity to the drug and its components. It should be used with caution in women of reproductive age. When using sofosbuvir in combination with ribavirin and interferon alfa, pregnancy is undesirable. Avoid using sofosbuvir during pregnancy and lactation. There are no data on the effect of sofosbuvir on reproduction.
Dosage
Therapy should be carried out only by physicians experienced in the treatment of chronic hepatitis C. It is recommended to use the drug in combination with other medications. Sofosbuvir monotherapy is not recommended.
Combination therapy:
- For hepatitis C genotype 4, 5 or 6, the combination of sofosbuvir + ribavirin + interferon alfa is used for more than 12 weeks.
- With hepatitis C genotype 1, 4, 5 or 6 - sofosbuvir + ribavirin (only in patients with contraindications to the use of Interferon alfa or who have an intolerance to Interferon) for more than 24 weeks.
- For hepatitis C genotype 2 - sofosbuvir + ribavirin for more than 12 weeks.
- For hepatitis C genotype 3 - sofosbuvir + ribavirin + interferon alfa for more than 12 weeks.
- Patients with hepatitis C who are awaiting liver transplant receive the combination sofosbuvir + ribavirin before transplantation.
- The scheme is valid for patients with co-infection of hepatitis and HIV.
There are no data on the use of combination therapy with sofosbuvir + ribavirin + interferon alfa in patients with hepatitis C genotype 1.
The duration of therapy can be increased to 24 weeks, especially in patients with one or many negative factors, such as progressive fibrosis / cirrhosis, high baseline viral load, black skin, previously unresponsive to ribavirin and interferon alfa.
The dose of ribavirin in combination therapy depends on the patient's weight (<75 кг =1.000 мг и >75 kg \u003d 1,200 mg), divided into two and taken with meals.
If, when taking sofosbuvir with interferon alfa, there are serious side effects associated with this drug, you should reduce the dose of interferon or completely stop taking the drug. The rules for reducing the dose or stopping taking interferon are prescribed in special instructions.
If serious side effects associated with ribavirin occur, the dose of ribavirin should be reduced accordingly or the drug should be completely discontinued. The rules for dose reduction or discontinuation of ribavirin are prescribed in special instructions.
After discontinuation of ribavirin based on improved blood counts and clinical symptoms, an attempt can be made to resume taking the drug at a dosage of 600 mg daily, increasing it to 800 mg. However, further administration of the drug in the initial dose (1,000 mg and 1,200 mg daily) is not recommended.
Termination of treatment:
In case of complete cancellation of one of the drugs with combined administration, the administration of sofosbuvir should also be canceled.
Children and adolescents:
There are no data on the safety and efficacy of taking sofosbuvir in children and adolescents under the age of 18.
Patients with mild to moderate renal impairment do not require special dose selection. Patients with severe renal failure receive specific doses of the drug.
Patients with mild, moderate and severe liver failure do not require special dose selection.
Method and duration of admission
- Due to the bitter taste, the tablet should be swallowed without chewing or dividing it into parts. Take with meals.
- If vomiting occurs within 2 hours after taking the medication, an additional pill should be taken. In case of vomiting after 2 hours, there is no need to take an additional tablet.
- If a medication is missed, if you are less than 18 hours late, you must take the missed pill. The next pill is taken at the usual time. If you are more than 18 hours late, take the next pill at the usual time.
Properties of the drug
Sofosbuvir is an inhibitor of NS5B RNA polymerase, inhibits the replication of the hepatitis C virus.
special instructions
When using Sofosbuvir in combination with Ribavirin and Interferon alfa, pregnancy is undesirable.
Interaction with other medicines
Using sofosbuvir with others antiviral drugs may only be permitted if the evidence indicates the benefits outweigh the potential risks. Co-administration of sofosbuvir and telaprevir or boceprevir is not recommended. It is not recommended to take sofosbuvir in conjunction with drugs that are strong inducers of glucoproteins in the intestine (rifamycin, St. John's wort, carbamatsepin and phenytoin).
Side effects
The general data on side effects while taking sofosbuvir in combination with ribavirin and / or interferon alfa are consistent with the picture of treatment with ribavirin and interferon alfa, without aggravating or increasing side effects.
Very often (\u003e 10%):
- With the combination of sofosbuvir + ribavirin: - a decrease in the concentration of hemoglobin in the blood - insomnia - headaches - nausea - an increase in bilirubin in the blood - fatigue, irritability
- With the combination of sofosbuvir + interferon alpha + ribavirin: - anemia, neutropenia, a decrease in the number of lymphocytes and platelets - decreased appetite - insomnia - dizziness, headaches - shortness of breath, cough - diarrhea, nausea, vomiting - increased bilirubin in the blood - skin rashes, itching - joint pains, myalgia - chills, fatigue, irritability, pain, temperature
Often (\u003e 1% and<10%)
- With a combination of sofosbuvir + ribavirin: - rhinopharyngitis - anemia - depression - concentration disorders - shortness of breath, shortness of breath on exertion, cough - intestinal disorders, constipation, dyspepsia - hair loss, dry skin, itchy skin - joint pain, back pain, cramps, myalgia - temperature, asthenia
- With the combination of sofosbuvir + interferon alfa + ribavirin: - weight loss - depression, fear, anxiety - migraine, memory impairment, concentration disorders - visual impairment - shortness of breath on exertion - constipation, dry mouth, reflux - hair loss, dry skin - pain in back, cramps - chest pains, asthenia