Effective dual-action antipyretic drug

Complementary combination

Rapid temperature drop for a long time

Not only relieves fever, but also fights inflammation

Can be prescribed to children from 3 years of age

Ibuklin tablets - official instructions for use

INSTRUCTION
on the use of a medicinal product for medical use

Registration number:

P N011252 / 01

Trade name of the drug:

INN or drug grouping name:

Ibuprofen + Paracetamol

Dosage form:

film-coated tablets

Composition:

Each film-coated tablet contains:
Active substances: ibuprofen 400 mg and paracetamol 325 mg.
Excipients: microcrystalline cellulose 120 mg, corn starch 76 mg, glycerol 3 mg, sodium carboxymethyl starch (type A) 7 mg, colloidal silicon dioxide 5 mg, talc 8 mg, magnesium stearate 6 mg.
Sheath:hypromellose 6 cps 11.32 mg, sunset yellow dye (E110) aluminum varnish 1.78 mg, macrogol-6000 2.2 mg, talc 4.06 mg, titanium dioxide 0.16 mg, polysorbate-80 0.16 mg , sorbic acid 0.16 mg, dimethicone 0.16 mg.

Description:

Capsule-shaped tablets, orange-coated, with a line on one side; for individual tablets, marbling of color is allowed.

Pharmacotherapeutic group:

combined analgesic agent (NSAIDs + non-narcotic analgesic agent).

ATX code:

M01AE51

Pharmacological properties

Pharmacodynamics

Combined drug, the action of which is due to its constituent components.

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that has an analgesic, anti-inflammatory, antipyretic effect. By inhibiting cyclooxygenase (COX) 1 and 2, it disrupts the metabolism of arachidonic acid, reduces the amount of prostaglandins (mediators of pain, inflammation and hyperthermic reaction), both in the focus of inflammation and in healthy tissues, suppresses the exudative and proliferative phases of inflammation.

Paracetamol - indiscriminately blocks COX, mainly in the central nervous system, has little effect on water-salt metabolism and the mucous membrane of the gastrointestinal tract (GIT). It has analgesic and antipyretic effects. In inflamed tissues, peroxidases neutralize the effect of paracetamol on COX 1 and 2, which explains the low anti-inflammatory effect.

The effectiveness of the combination is higher than that of the individual components. Weakens arthralgia at rest and during movement, reduces morning stiffness and swelling of the joints, helps to increase the range of motion.

Pharmacokinetics

Ibuprofen.
Absorption - high, quickly and almost completely absorbed from the gastrointestinal tract (GIT). The time to reach the maximum concentration (TCmax) after oral administration is about 1-2 hours. The connection with blood plasma proteins is more than 90%. The half-life (T1 / 2) is about 2 hours. It slowly penetrates into the joint cavity, accumulates in the synovial fluid, creating higher concentrations in it than in the blood plasma. After absorption, about 60% of the pharmacologically inactive R-form is slowly transformed into the active S-form. Metabolized. More than 90% is excreted by the kidneys (not more than 1% unchanged) and, to a lesser extent, with bile in the form of metabolites and their conjugates.

Paracetamol.
Absorption is high, the connection with plasma proteins is less than 10% and slightly increases in case of an overdose. Sulfate and glucuronide metabolites do not bind to plasma proteins even at relatively high concentrations. The value of Cmax is 5-20 μg / ml, TCmax is 0.5-2 hours. It is fairly evenly distributed in the body fluids.
Penetrates the blood-brain barrier.
About 90-95% of paracetamol is metabolized in the liver to form inactive conjugates with glucuronic acid (60%), taurine (35%) and cysteine \u200b\u200b(3%), as well as a small amount of hydroxylated and deacetylated metabolites. A small part of the drug is hydroxylated by microsomal enzymes to form highly active N-acetyl-n-benzoquinone imine, which binds to sulfhydryl groups of glutathione. When glutathione reserves in the liver are depleted (in case of overdose), the enzyme systems of hepatocytes can be blocked, leading to the development of their necrosis. T1 / 2 - 2-3 hours. In patients with liver cirrhosis, T1 / 2 increases slightly. In elderly patients, drug clearance decreases and T1 / 2 increases. It is excreted by the kidneys mainly in the form of glucuronide and sulfate conjugates (less than 5% - unchanged). Less than 1% of the taken dose of paracetamol penetrates into breast milk. In children, the ability to form conjugates with glucuronic acid is lower than in adults.

Indications for use

• feverish conditions (including flu and colds);
• myalgia;
• neuralgia;
• back pain;
• joint pain, pain syndrome in inflammatory and degenerative diseases of the musculoskeletal system;
• pain with bruises, sprains, dislocations, fractures;
• post-traumatic and postoperative pain syndrome;
• toothache;
• algodismenorrhea (painful menstruation).

The drug is intended for symptomatic therapy, reducing pain and inflammation at the time of use, does not affect the progression of the disease.

Contraindications for use

Hypersensitivity to the components of the drug (including other NSAIDs), gastric ulcer and duodenal ulcer in the acute phase, gastrointestinal bleeding, severe renal failure (creatinine clearance (CC) less than 30 ml / min), complete or incomplete combination bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance acetylsalicylic acid or other NSAIDs (including a history), optic nerve damage, genetic absence of glucose-6-phosphate dehydrogenase, diseases of the blood system, the period after coronary artery bypass grafting; progressive kidney disease, severe liver failure or active liver disease, confirmed hyperkalemia, active gastrointestinal bleeding, inflammatory bowel disease, pregnancy (III trimester), childhood up to 12 years old.

Application during pregnancy and lactation

In the I and II trimesters of pregnancy, use is possible only as directed by a doctor in those cases when the potential benefit outweighs the possible risk to the mother and the potential risk to the fetus. The use of the drug in the third trimester of pregnancy is contraindicated.
If necessary, use the drug during lactation ( breastfeeding) breastfeeding should be stopped.
In experimental studies, the embryotoxic, teratogenic and mutagenic effects of the components of the Ibuklin® drug have not been established.

Method of administration and dosage regimen

Inside (before or 2-3 hours after eating), without chewing, drinking plenty of water.
Adults. 1 tablet 3 times a day. The maximum daily dose is 3 tablets.
Children over 12 years old (body weight over 40 kg). 1 tablet 2 times a day.
The duration of treatment is no more than 3 days as an antipyretic agent and no more than 5 days as a pain reliever. Continuation of treatment with the drug is possible only after consulting a doctor.

Precautions for use

Ischemic heart disease, chronic heart failure, cerebrovascular disease, dyslipidemia / hyperlipidemia, diabetes mellitus, peripheral arterial disease, smoking, CC less than 60 ml / min, gastrointestinal ulcers in history, Helicobacter pylori infection, advanced age, long-term use of NSAIDs, alcoholism , severe somatic diseases, concomitant use of oral glucocorticosteroids (including prednisolone), anticoagulants (including warfarin), antiplatelet agents (including acetylsalicylic acid, clopidogrel), selective serotonin reuptake inhibitors (including citaluoxetinetinam, foxetinam, foxetinam sertraline).
Viral hepatitis, hepatic and / or renal failure of moderate and mild severity, benign hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndrome), liver cirrhosis with portal hypertension, nephrotic syndrome.

Overdose symptoms, overdose relief measures

Symptoms: gastrointestinal disorders (diarrhea, nausea, vomiting, anorexia, epigastric pain), increased prothrombin time, bleeding after 12-48 hours, lethargy, drowsiness, depression, headache, tinnitus, impaired consciousness, heart rhythm disturbances, decreased blood pressure, manifestations of hepato- and nephrotoxicity, convulsions, possibly the development of hepatonecrosis. If you suspect an overdose, you should immediately seek medical help.

Treatment: gastric lavage for the first 4 hours; alkaline drinking, forced diuresis; activated charcoal inside, administration of SH-group donors and precursors of glutathione-methionine synthesis 8-9 hours after overdose and N-acetylcysteine \u200b\u200binside or intravenously - after 12 hours, antacids; hemodialysis; symptomatic therapy. The need for additional therapeutic measures (further administration of methionine, intravenous administration of N-acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as on the time elapsed after its administration.

Possible side effects

From the gastrointestinal tract (GIT): NSAID-gastropathy - nausea, vomiting, heartburn, anorexia, epigastric discomfort or pain, diarrhea, flatulence; rarely - erosive and ulcerative lesions, bleeding; liver dysfunction, hepatitis, pancreatitis; irritation or dryness in the mouth, pain in the mouth, ulceration of the gum mucosa, aphthous stomatitis; constipation.
From the nervous system and sensory organs: headache, dizziness, insomnia, anxiety, nervousness, irritability, agitation, drowsiness, depression, confusion, hallucinations; rarely - aseptic meningitis (more often in patients with autoimmune diseases); hearing loss, tinnitus, visual impairment, toxic damage to the optic nerve, blurred vision or double vision, scotoma, amblyopia.
From the side of the cardiovascular system: heart failure, increased blood pressure, tachycardia.
From the side of hematopoiesis: anemia (including hemolytic and aplastic), thrombocytopenia, thrombocytopenic purpura, agranulocytosis, leukopenia.
From the side respiratory system: shortness of breath, bronchospasm.
From the urinary system: allergic nephritis, acute renal failure, nephrotic syndrome, edema, polyuria, cystitis.
Allergic reactions: skin rash, itching, urticaria, Quincke's edema, bronchospasm, dyspnea, allergic rhinitis, dryness and irritation of the eyes, edema of the conjunctiva and eyelids, eosinophilia, fever, anaphylactic shock, erythema multiforme (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome).
Laboratory indicators: a decrease in serum glucose concentration, a decrease in hematocrit and hemoglobin, an increase in bleeding time, an increase in serum creatinine concentration, an increase in the activity of "hepatic" transaminases.
Others: increased sweating.
With prolonged use in high doses: ulceration of the mucous membrane of the gastrointestinal tract, bleeding (gastrointestinal, gingival, uterine, hemorrhoidal), visual impairment (impaired color vision, scotoma, amblyopia).

Interaction with other drugs and (or) food

With the simultaneous use of the drug Ibuklin ® with medicines development of various interaction effects is possible.
When taken simultaneously with acetylsalicylic acid, ibuprofen reduces its anti-inflammatory and antiaggregatory effect (it is possible to increase the incidence of acute coronary insufficiency in patients receiving small doses of acetylsalicylic acid as an antiaggregatory agent, after the start of admission).
The combination with ethanol, glucocorticosteroids, corticotropin increases the risk of erosive and ulcerative lesions of the gastrointestinal tract.
Ibuprofen enhances the action of direct (heparin) and indirect (coumarin and indandione derivatives) anticoagulants, thrombolytic agents (alteplase, anistreplase, streptokinase, urokinase), antiplatelet agents, colchicine - the risk of hemorrhagic complications increases.
Enhances the hypoglycemic effect of insulin and oral hypoglycemic drugs.
Weakens the effects of antihypertensive drugs and diuretics (by inhibiting the synthesis of renal prostaglandins).
Increases the concentration in the blood of digoxin, lithium preparations and methotrexate.
Caffeine enhances the analgesic effect of ibuprofen.
Cyclosporine and gold preparations increase nephrotoxicity.
Cefamandol, cefoperazone, cefotetan, valproic acid, plikamycin increase the incidence of hypoprothrombinemia.
Antacids and cholestyramine reduce the absorption of the drug.
Myelotoxic drugs contribute to the manifestation of the drug's hematotoxicity.

special instructions

Avoid the simultaneous use of the drug with other drugs containing paracetamol and / or non-steroidal anti-inflammatory drugs. When using the drug for more than 5-7 days as directed by a doctor, the peripheral blood parameters and the functional state of the liver should be monitored.
With the simultaneous use of indirect anticoagulants, it is necessary to monitor the indicators of the blood coagulation system.
Avoid co-administration of the drug Ibuklin ® with other NSAIDs.
To avoid possible damaging effects on the liver, you should not drink alcohol while taking the drug.
The drug can distort the results of laboratory tests in the quantitative determination of glucose, uric acid in the blood serum, 17-ketosteroids (the drug must be discontinued 48 hours before the study).

Influence on the ability to drive vehicles, mechanisms

During the period of treatment, the patient should refrain from engaging in potentially hazardous activities that require increased attention and speed of psychomotor reactions.

Release form

Film-coated tablets, 400 mg + 325 mg.
10 tablets in PVC / Al blister.
1, 2 or 20 blisters are packed in a cardboard box with instructions for use.

Storage conditions

Store in a dry, dark place and out of reach of children at a temperature not exceeding 25 ° C.

Ibuklin refers to drugs that relieve pain, inflammation and fever. It is used in symptomatic therapy without affecting the progression of the disease.

General information from the instructions for use

Form and composition

Ibuklin reduces pain and inflammation of a different nature. The effectiveness of the drug is indicated by the reviews of the people taking it at the end of the article.

The drug is available in capsule-shaped tablets. They have a risk on one side and are covered with a filmic orange shell. Sometimes there is a marble color. The medicine has a five-year shelf life.

One tablet is characterized by a composition with active ingredients:

• ibuprofen (400 mg),
• paracetamol (325 mg).

Excipients are:

• 120 mg MCC,
• 76 mg corn starch
• 3 mg gricerol,
• 7 mg sodium carboxymethyl starch,
• 5 mg colloidal silicon dioxide
• 8 mg talc
• 6 mg magnesium stearate.

The film casing includes:

• hypromellose 6 cps,
• dye of yellow color "Sunsets",
• aluminum varnish,
• talc,
• macrogol,
• titanium dioxide,
• polysorbate,
• sorbic acid,
• dimethicone.

How the components of the drug work

Ibuprofen is a non-steroidal anti-inflammatory agent with analgesic, antipyretic and anti-inflammatory action. Its main task is to reduce pain mediators, hyperthermic reactions and inflammation.

Absorption of ibuprofen from the stomach and intestines occurs quickly and in almost full volume. It gradually penetrates into the articular cavity, replenishes the synovial fluid, creating a concentration higher than in blood plasma.

Paracetamol by a common front blocks inflammatory enzymes, mostly in the central nervous system. It has a weak effect on the mucous membrane of the stomach and intestines. Possesses high absorption, evenly distributed in the liquid areas of the body.

In combination, these components have a greater effect than separately. Their combination drowns out arthralgia in movement and at rest, reduces joint stiffness in the morning and their swelling, expands the range of motion.

About indications

This tool is useful for:

• joint pain and pain syndrome in the musculoskeletal system of a degenerative and inflammatory nature;
• pain due to bruises, sprains, fractures, dislocations;
• back pain;
• neuralgia,
• myalgia,
• febrile conditions (including colds and flu);
• toothache;
• postoperative and post-traumatic pain syndrome;
• painful periods.

Who should be careful

Circle of contraindications

Ibuklin cannot be used if you have:

• pathological sensitivity to the constituent parts of the drug (and its analogues),
• aggravated stomach ulcer,
• bleeding in the stomach and intestines,
• renal failure in acute form and progressive kidney disease,
• damage to the optic nerve,
• combinations of nasal polyposis with bronchial asthma,
• diseases of the blood systems,
• coronary aortic bypass grafting,
• severe liver failure or active liver disease,
• hyperkalemia,
• pregnancy,
• under 12 years of age.

Don't forget about side effects

As a side effect of taking the drug, there may be:

• heartburn, epigastric discomfort, vomiting, anorexia;
• insomnia, nervousness, dizziness with headache, depression;
• high blood pressure, tachycardia, heart failure;
• anemia, leukopenia;
• bronchospasm, shortness of breath;
• cystitis, edema, nephrotic syndrome, liver failure;
• allergic manifestations of a varied nature;
• increased sweating.

This list is far from complete.

Results of interactions with other medications

Some examples of drug compatibility with Ibuclin:

1. Taking it together with aspirin lowers its anti-inflammatory effect.
2. The simultaneous use of ethanol or corticotropin increases the risk of stomach ulcers.
3. The effect of anticoagulants (for example, heparin) is enhanced, which threatens hemorrhagic complications.
4. There is an increase in the hypoglycemic effect of insulin.
5. The effect of diuretics and antihypertensive drugs decreases.
6. In combination with caffeine, the analgesic effect of ibuprofen is enhanced.
7. The combination with cyclosporine and gold preparations increases nephrotoxicity.
8. The absorption of the drug decreases from antacids.

Practical use issues

How and how much to take

Taking pills should come before meals. If this is not done, then you can take the medicine after eating two to three hours later. They are washed down with water in large quantities without chewing.

Adults are usually prescribed a tablet three times a day. The dose of the medicine for the whole day cannot be higher than three tablets.

Children after 12 years of age drink a tablet twice a day.

As an antipyretic, Ibuklin should be taken no more than three days. For pain relief - no more than five days. The increase in these terms must be agreed with the doctor.

It is better not to use the drug in conjunction with other drugs containing paracetamol or other non-steroidal anti-inflammatory agent.

What can replace the price

The price of Ibuklin in Russian pharmacies is on average 80-100 rubles. (for 10 tablets). Its average cost in Ukraine is 30 UAH.

Synonyms for the drug include:

• Ibuklin junior,
• Spondifen,
• Brustan.

Analogs:

• Diklo-F,
• Rapten,
• Long,
• Remisides.

The pharmacy sells many combination drugs that can be purchased without a doctor's prescription. One of the most effective is Ibuklin. The drug is very popular because it has a triple effect due to the interaction of two main components - ibuprofen and paracetamol. Find out how to take Ibuclin for maximum benefit.

Ibuklin - indications for use

When prescribing a medicine, doctors use an individual approach to each patient, because the medicine has significant contraindications. The remedy is often prescribed for patients suffering from a febrile condition with colds and flu. When used correctly, the agent has an analgesic, anti-inflammatory and antipyretic effect. It is effective for inflammatory diseases of the musculoskeletal system, for menstruation, tendovaginitis. Othersindications for the use of Ibuklinaccording to the instructions:

• myalgia;
• toothache, headache;
• gouty arthritis, psoriatic arthritis;
• post-traumatic pain syndromes;
• bursitis;
• pain with osteochondrosis of the spine;
• soft tissue bruises, stretch marks, dislocations;
• adnexitis;
• deforming osteoarthritis;
• pharyngitis, otitis media and other diseases of the ENT organs.

Ibuklin - composition

The drug has many-sided positive effects due to the active substances it contains. These are Ibuprofen and Paracetamol. Both substances are equally effective, perfectly complement each other's action and have good compatibility in use. According to the instructions, Ibuprofen is absorbed into the bloodstream and stops the production of prostaglandins, pain mediators, reduces inflammation, and has an antipyretic effect.

Paracetamol begins to act even faster than the previous substance. It has an average anti-inflammatory effect, blocks COX, perfectly relieves pain, relieves temperature and swelling of the joints. In combination with Ibuprofen, it works more effectively than alone. INcomposition of Ibuklinthere are also excipients: lactose, corn starch, glyceryl, colloidal silicon dioxide and others.

Ibuklin - instruction

The drug does not delay the progression of the disease, but is effective for symptomatic therapy. Everyone who is going to use it for medicinal purposes should know about this property of the medicine. You should definitely familiarize yourself withibuklin's instructions, pharmacology, contraindications. In addition, it is important to study the dosage and rules for use by adults and children.

Ibuklin Junior

For the treatment of young patients, a children's version is produced with the name Ibuklin Junior. The packaging is similar to that of an adult, the composition is similar, but the content of active ingredients is lower in it. For example, one Junior tablet contains 100 mg of ibuprofen and 125 mg of paracetamol. Pineapple and orange flavors have been added to enhance the palate.Ibuklin for children assigned to kids over 2 years old. The instructions indicate the exact dosage depending on the weight, age of the baby. According to the instructions, the drug is effective:

• with infectious diseases;
• with degenerative diseases of the musculoskeletal system;
• elevated temperature body;
• ruptures, sprains;
• burns;
• sore throat.

Ibuklin for adults

The medicine is available in the form of capsules with a noticeable orange-colored shell.Ibuklin for adults recommended for symptomatic treatment, it does not affect the underlying disease. Helps in the following cases:

• toothache;
• sciatica;
• rheumatoid arthritis;
• chronic arthritis;
• with diseases of the periarticular tissues;
• ankylosing spondylitis;
• fractures, dislocations;
• juvenile arthritis;
• pain syndrome after surgery;
• painful periods in women;
• fever not controlled by other single-component drugs;
• tracheitis, otitis media.

Ibuklin during pregnancy

Tablets are rarely used to treat women in position. One-time use is permissible, but regular use is strictly prohibited. In exceptional cases, pills can be prescribed in the first and second trimesters. After 30 weeks, the drug increases the risk of developing kidney pathology in the fetus. If a woman needs an anti-inflammatory, antipyretic drug, it is better to use the safer Paracetamol.Ibuklin while breastfeeding let's say after consulting a doctor. Drink it after feeding.

Ibuklin - contraindications

Ibuklin's abstract contains a complete list of possible side effects and a list of contraindications. Reception should be suspended if the patient develops a skin rash, itching, leukopenia, agranulocytosis.Contraindications Ibuklin:

• blood diseases;
• stomach ulcer during an exacerbation;
• hypersensitivity to components;
• bronchial asthma;
• liver disease;
• renal failure;
• cardiovascular diseases;
• recurrent polyposis of the nose, sinuses;
• inflammation in the intestines;
• taking other NSAIDs;
• damage to the optic nerve.

Ibuklin - analogues

Other medicines can be found on the market that contain similar active ingredients. Famousanalogue of Ibuklin is Next - a drug consisting of paracetamol and ibuprofen. The same active ingredients are found in Brustan, Khairumat. These medicines are not suitable for children due to the high content of active ingredients. If it was not possible to purchase the Junior remedy, the remedy can be replaced with children's Panadol.

Ibuklin price

An important advantage of tablets is their affordable price. The medicine can be bought in the online store, ordered through catalogs and purchased from pharmacies.How much is Ibuklin? The price depends on the form of release. For example, children's Junior costs from 90 rubles for 20 tablets. The adult form of the drug is sold a little more expensive, its price is from 100 rubles and more. Some Ibuclin analogues will cost more.

Ibuklin is a typical representative of a group of drugs called non-steroidal anti-inflammatory drugs. According to the international classification, the drug belongs to anti-inflammatory and antirheumatic drugs, which are ibuprofen derivatives and its combinations.

Indications for use Ibuklin

Due to its complex composition, the drug has a wide range of effects, which ensures its use in many fields of medicine.

So, indications for the use of Ibuclin include severe hyperthermia, and fever can have a different genesis of origin. It can be both colds and more serious infectious diseases with severe inflammation.

Ibuklin copes well with pain syndrome, but its degree should not be excessively large. The drug relieves the average intensity of pain in the presence of an inflammatory focus in the bones, joints and muscles, for example, with gouty or rheumatoid arthritis, ankylosing spondylitis.

Indications for the use of Ibuklin in the fight against pain syndrome are represented by degenerative processes in the joints and bone structures with deforming osteoarthritis and osteochondrosis.

The drug is effective for tendovaginitis and bursitis, when the periarticular capsule is involved in the process. Lumbago, neuralgia, muscle pain, as well as post-traumatic injuries in sprains, sprains, fractures and bruises are also the basis for the use of Ibuclin.

The most common uses include headache, toothache, and joint pain.

Release form

The main characteristics of this pharmaceutical product are its form of release, which is represented by a tablet preparation, as well as its physicochemical properties. They include the coating of each tablet with a film coating, the shade of which varies from a light orange to a more intense color.

It is also worth highlighting the capsule-like shape, which has a dividing strip on one side, and a smooth surface on the other.

The release form in the form of tablets determines the packaging of the drug. So, Ibuklin comes with 10 tablets in one blister, which corresponds to one cardboard package.

Each tablet contains 400 mg ibuprofen and 323 mg paracetamol. In addition to the main components, there are several additional ones, for example, cellulose, starch, glycerin and others.

The tablet form is very convenient to use, since due to the specific composition of each tablet, you can strictly monitor the dose and avoid overdose.

Pharmacodynamics

Pharmacodynamic properties are due to the main components of the drug - ibuprofen and paracetamol.

Each of the above components has certain capabilities, which, in combination with another component, provides a pronounced therapeutic effect.

The pharmacodynamics of Ibuclin is a complex of actions of both drugs, which have analgesic and anti-inflammatory effects. By blocking cyclooxygenase, the drug not only reduces the manifestations of the inflammatory reaction, but also acts as an antipyretic agent.

As for paracetamol, on its own it is not able to provide a pronounced anti-inflammatory effect, since its activity is inhibited by peroxidases. As a result, Ibuklin additionally contains ibuprofen to enhance the therapeutic effect.

The components of the drug, providing a combined effect, provides a reduction in pain in the joints, which in turn leads to a decrease in stiffness in motor activity and restores the previous joint mobility.

Pharmacokinetics

The complex drug consists of two main active drugs, therefore the pharmacokinetics of Ibuclin is based on the combined action of both components.

So, ibuprofen quickly penetrates into the general bloodstream through the mucous membrane of the digestive system after oral use. After a couple of hours, its maximum concentration in plasma is observed.

Almost 99% of ibuprofen binds to plasma proteins, with which it is carried through the bloodstream. The excretion of ibuprofen is carried out by filtration by the kidneys unchanged or in the form of oxidized metabolites in an inactive form.

In the above ways, all ibuprofen metabolites are excreted from the body within 24 hours, and after 24 hours the person completely gets rid of the drug.

The pharmacokinetics of Ibuclin, which contains paracetamol, is due to good absorption. Half an hour after taking the tablet preparation inside, the concentration of paracetamol in the bloodstream reaches its maximum value. This level persists for 4 hours and gradually begins to decline.

As for the connection with blood proteins, paracetamol is transported in a complex with them only in a partial amount (approximately 25%). After 1.5-2 hours, only half of the taken dosage remains in the human body. Metabolism occurs in the liver with the formation of glucuronides and sulfates. Paracetamol is excreted by the kidneys, gradually decreasing the concentration in the blood and increasing in the urine.

Use of Ibuklin during pregnancy

Throughout the entire period of pregnancy and after childbirth, when the baby is breastfed, any medication should be taken under the supervision of a doctor. This is due to the high probability of getting the drug to the child.

The use of Ibuclin during pregnancy is permitted if the benefits to the expectant mother are significantly higher than the harm to the fetus. During the experiments, it was concluded that Ibuklin is not capable of exerting mutagenic or teratogenic effects.

Especially carefully you need to use drugs in the first trimester of pregnancy, when there is a gradual laying of fetal organs. In the future, their formation and development takes place.

The use of Ibuclin during pregnancy usually does not harm the woman and the fetus, however, it is necessary to strictly control the dosage and duration of the drug intake in order to avoid negative effects on the fetus.

Contraindications

In order for the drug to have a therapeutic effect without the appearance of side reactions and aggravation of the condition, it is necessary to know the contraindications to the use of Ibuklin.

These include the age of babies up to 12 years old, the individual characteristics of the body, when responses to the introduction of a certain drug component are genetically laid down. Also, contraindications to the use of Ibuclin include the presence of ulcerative defects in the mucous membrane of the digestive system and bleeding in the acute phase.

It is not recommended to take Ibuclin for renal failure in the stage of decompensation, for combined pathology of the paranasal sinuses with bronchial asthma, polyposis and an allergic reaction to acetylsalicylic acid.

In addition, Ibuklin is not desirable for use in case of damage to the optic nerve, pathology of the circulatory system, in the early period after coronary artery bypass grafting, as well as in severe liver pathology, inflammatory bowel disease and an increased amount of potassium in the blood.

Most often, you can observe a rash of various diameters and shapes, tingling sensations, itching, up to the development of urticaria and Quincke's edema. In addition, from the manifestations, pain in the stomach and abdomen, nausea, light dizziness, vomiting, headache and visual impairment can be distinguished.

Side effects of Ibuclin can also relate to impaired renal function, the appearance of erosive damage to the mucous membrane of the digestive system and changes in the blood picture with a decrease in the number of platelets, erythrocytes, changes in the size of blood cells, hyperkalemia, hyperuricuria and azotemia.

With the appearance of pain in the stomach and vomiting, it is necessary to monitor the color of the vomit. If it resembles "coffee grounds", then you need to urgently call an ambulance. These symptoms signal the onset of gastric bleeding.

In addition, bleeding from the intestines is indicated by the appearance of blood in the feces (the so-called melena). This condition also requires immediate medical attention.

Method of administration and dosage

The tablet form of the drug involves taking it orally a couple of hours before or after a meal. The tablet should not be chewed or swallowed whole with a few sips of water.

The method of administration and doses of medicines are selected individually, taking into account the degree of the disease, age and state of health of the person.

Since babies under 12 years old do not have permission to take this drug, then at an older age and adults can use it 1 tablet up to 3 times a day. It is necessary to observe a certain interval between taking the medication, which should not be less than 4 hours.

It should be noted that a single dose of the Ibuklin tablet drug is a maximum of 2 tablets, and for a daily dosage - a maximum of 6 tablets.

The method of administration and dose should be adjusted in elderly people, as well as in the presence of severe concomitant pathology. So, they have a break between taking the drug should not be less than 8 hours.

Without the supervision of a doctor, the use of Ibuclin as an antipyretic agent is approximately 3 days, and as an anesthetic drug - no more than 5 days.

If the drug Ibuklin must be taken for a long time, then the functioning of the liver, kidneys and the state of the circulatory system should be monitored using laboratory research methods.

Overdose

In the case when the dosage and duration of admission are not observed, the likelihood of an overdose increases. In this case, according to certain nonspecific symptoms, one can suspect the effect of drug accumulation and an increase in its side effects.

An overdose of Ibuclin can manifest itself in the form of digestive disorders with nausea, vomiting and pain in the epigastric zone. Clinical signs of hepatotoxic syndrome, impaired consciousness, headache, decreased blood pressure and pale skin are also possible.

When observing such symptoms, it is necessary to carry out some procedures that will remove metabolites and drug residues.

So, first you need to flush the stomach so that part of the drug that has not yet had time to be absorbed can be excreted from the body. In addition, it is necessary to take activated carbon, which is a sorbent. It will also help block the further flow of the drug into the bloodstream.

Overdose in some cases requires hemodialysis and monitoring of the blood picture. In case of electrolyte imbalance, the deficiency should be filled and the indicators returned to normal.

Ibuklin's storage conditions provide for compliance with the temperature regime without sudden fluctuations, humidity and illumination. So, the temperature of the room where the medicine is supposed to be stored should not be higher than 25 degrees. Higher values \u200b\u200bcan disrupt the structure of the drug and ahead of time suitability to make it harmful to humans.

The place where the medication will be located during the shelf life should not be excessively illuminated by sunlight, which is also unacceptable for storage.

The storage conditions of Ibuklin provide for the lack of access for the baby to the location of the drug. Its reception can be complicated by laryngospasm or poisoning, which is unacceptable in childhood.

special instructions

Ibuklin, due to its composition of several main components, is a combined remedy. Its main ingredients are ibuprofen and paracetamol.

The first one is able to reduce the intensity of the inflammatory reaction, thereby reducing the severity of hyperemia, swelling and pain. In addition, it has antipyretic properties.

Its mechanism of action is based on inhibition of the activity of cyclooxygenase 1,2 and disruption of the conversion of arachidonic acid. The amount of prostaglandins, which are mediators of the inflammatory reaction with the formation of hyperthermia and painful sensations, also decreases. Similar phenomena are observed in the lesion focus and healthy tissues, where the exudative and proliferative inflammatory stage is suppressed.

In turn, paracetamol, blocking COX in the structures of the central parts of the nervous system, has a lesser effect on the exchange of water and trace elements, as well as the gastric mucosa.

The manufacturer usually indicates the date on the outside of the cardboard package for quicker access, as well as on each blister so that in case of loss of the box, the expiration date can be accessed by a person.