A drug that regulates the balance of the vaginal microflora, with an estrogenic component
Active ingredients
Estriol (estriol)
- lactobacillus acidophilus (lyophilisate)
Release form, composition and packaging
◊ Vaginal pills from white to light beige interspersed, oval, biconvex.
* at least 100 million viable bacteria.
Excipients: lactose monohydrate - 625.6 mg, microcrystalline cellulose - 183.7 mg, magnesium stearate - 6.67 mg, sodium carboxymethyl starch - 30 mg, sodium dihydrogen phosphate - 4 mg.
6 pcs. - contour cell packaging (1) - cardboard packs.
pharmachologic effect
The active substances that make up the preparation Gynoflor E, estriol and acidophilic lactobacilli participate in the physiological mechanism of maintaining normal vaginal biocinosis.
Lactobacillus acidophilus- one of the dominant microorganisms of the vagina of a healthy woman with antagonistic activity against pathogenic and opportunistic microorganisms.
Estriol - female sex hormone, short-acting estrogen, has a protective trophic effect on the vaginal epithelium and does not have a systemic effect on the woman's body. The proliferating mature vaginal epithelium accumulates glycogen, which is necessary for the functioning of lactobacilli, which, in turn, produce lactic acid, maintaining the acidic environment of the vagina (pH 3.8-4.5), which creates unfavorable conditions for the colonization and development of pathogenic microorganisms. In addition to lactic acid, acidophilic lactobacilli also produce bacteriocins, which also inhibit the development of pathogenic and opportunistic microorganisms.
A change in the physiological flora of the vagina occurs due to various factors: local or systemic use antibacterial drugs, incl. due to vaginal infections, systemic diseases, non-compliance with hygiene rules. In these cases, the number of lactobacilli can be significantly reduced. Intravaginal use of Gynoflor E improves the condition of the vaginal epithelium and restores its normal flora. Lactose, which is found in vaginal tablets as a filler, can also be fermented by lactobacilli into lactic acid.
The vaginal epithelium becomes thinner and can be damaged by hormonal disorders, and therefore Gynoflor E can be used in postmenopausal women to relieve its local symptoms (itching, burning, vaginal dryness, soreness during intercourse), contributing to the normalization of the state of the vaginal and urethral epithelium, reducing the frequency of dystrophic inflammatory conditions.
In vitro it was shown that acidophilic lactobacilli lead to the necessary decrease in pH within several hours. Estriol, with a treatment duration of 6-12 days, provides a proliferative trophic effect on the vaginal epithelium.
Pharmacokinetics
When the drug is injected into the vagina, lyophilized bacteria and estriol are released.
The absorption of estriol from the drug Gynoflor E has been studied in postmenopausal women. After repeated use of the drug, the concentration of estriol corresponds to the concentration of endogenous unbound estriol. After the 12th day of using vaginal tablets during treatment with Gynoflor E (1 time / day), the C max of unbound estriol in the blood plasma does not differ from the initial one, which indicates the absence of systemic absorption.
The use of the drug does not affect the concentration in the blood plasma of the sex hormones present in the body of a woman - estrone and estradiol, since estriol is the end product of their metabolism.
Indications
- restoration of the normal microflora of the vagina after local and / or systemic use of antibiotics or other drugs (including vaginal infections - bacterial vaginosis, nonspecific vulvovaginitis; urogenital infections and sexually transmitted diseases);
- estrogen-dependent atrophic vaginitis in postmenopausal women, incl. in combination with hormone replacement therapy (HRT).
Contraindications
- hypersensitivity to the drug or its components;
- malignant estrogen-dependent neoplasms, incl. mammary glands, uterus, ovaries, or vagina (diagnosed, history and suspected);
- (suspected or diagnosed);
- bleeding from the vagina of unclear etiology;
- use in girls before the onset of sexual activity;
- untreated endometrial hyperplasia.
Dosage
Vaginal tablets must be inserted deep into the vagina in the evening before going to bed, preferably in the supine position, with the knees slightly bent.
For restoration of normal vaginal microflora after local and / or systemic use of antibiotics or other antimicrobial drugs (including vaginal infections - nonspecific vulvovaginitis; urogenital infections and sexually transmitted diseases): 1-2 vaginal tablets daily for 6-12 days.
When treatment of estrogen-dependent postmenopausal women: 1 vaginal tablet daily for 6-12 days, then a maintenance dose - 1 vaginal tablet 1-2 times a week.
Side effects
Perhaps a burning sensation (heat) in the vagina, rarely - redness and itching of the vulva and vagina.
Overdose
Overdose of the drug was not observed.
Drug interactions
Lactobacillus acidophilus is sensitive to numerous antibacterial drugs (local or systemic use). Concomitant treatment with such agents can lead to a decrease in the effectiveness of the drug Gynoflor E. Therefore, the simultaneous use of the drug with antibacterial agents is not recommended.
special instructions
Gynoflor E contains components that may not completely dissolve; the remnants of a vaginal tablet can sometimes be found on underwear. This does not affect the effectiveness of the drug.
In isolated cases, with vaginal dryness, the vaginal tablet may not dissolve. To prevent such cases, before administration, the tablet can be moistened with a small amount of ordinary water - this will facilitate its faster dissolution. Patients are advised to use pads.
Influence on the ability to drive vehicles and mechanisms
Gynoflor E does not affect the ability to drive vehicles and mechanisms.
Storage conditions and periods
The drug should be stored out of the reach of children at a temperature of 2 ° to 8 ° C. Do not freeze. The shelf life is 3 years. Do not use after the expiration date.
1 tablet of Gynoflora E for vaginal use contains as active ingredients:
- lyophilisate acidophilic lactobacilli groups eubiotics (Lactobacillus acidophilus) - 50 mg (but not less than 100 million viable microorganisms);
- estriol - 0.03 mg.
Auxiliary substances of the active nucleus are:
- lactose monohydrate - 625.6 mg;
- microcrystalline cellulose (MCC) - 183.7 mg;
- carboxymethyl starch - 30 mg;
- magnesium stearate - 6.67 mg;
- sodium dihydrogen phosphate - 4 mg.
Release form
In pharmacies Gynoflor is supplied in the form vaginal biconvex tablets (another name for the release form is candles Gynoflor E) oval shape, 50 mg each, which are fixed in blisters made of aluminum foil or PVC, 6 pieces. Tablets of white or light beige color interspersed (intermediate shades of the indicated colors are possible). 1 or 2 contour cell plates are inserted into a cardboard package.
pharmachologic effect
The constituent components of the pharmaceutical preparation Gynoflor E are part of the physiological mechanism for maintaining normal vaginal biocenosis ... This is the main purpose of using the drug in conservative therapy.
Pharmacodynamics and pharmacokinetics
After the introduction of the drug into the vagina, the constituent components are released gradually, as they disintegrate under the influence of internal environmental factors. Lyophilized bacteria have only a local effect and are not absorbed into the systemic circulation. Their influence is noted after several hours.
Estriol with intravaginal use, it is able to be absorbed from the inner surface of the vaginal mucosa and enter the systemic circulation. The maximum plasma concentration is observed 3 hours after the administration of the pharmaceutical preparation. Estriol does not cumulate (after repeated administration, the plasma concentration corresponds to the amount of unbound) and does not affect the production of endogenous hormones of the estrogenic series ( and ), since it is their final link in the metabolic chain. The constituent components of Gynoflora are excreted in the urine for 8 hours.
Indications for use
- renewal physiologically normal microflora after local or systemic treatment with antibiotic drugs;
- mild to moderate bacterial or (a pharmaceutical product can be used both as a conservative treatment and as a preventive disease prevention);
- not specific vulvovaginitis ;
- (usually sexually transmitted infections);
- atrophic vaginitis as a result of the following etiological factors - estrogen deficiency during menopause or accompanying hormone replacement therapy ;
- bacterial secretions of unknown origin ( Fluor vaginalis);
- in an integrated drug treatment, against an infectious nature to maintain the normal microflora of a woman's body.
Contraindications
- hypersensitivity, hereditary or acquired intolerance to the constituent components of a pharmaceutical preparation;
- dependent on estrogen (in particular, when the process is localized in the mammary glands, uterus, ovaries or vagina);
- diagnosed or suspected ;
- hemorrhagic discharge from the vagina of unknown origin;
- hyperplasia ;
- use in girls before puberty (before the onset of sexual activity).
Side effects
As a rule, vaginal tablets are well tolerated by the female body, however, in some clinical cases, the following undesirable consequences of treatment may be observed:
- burning sensation , foreign body, or other kind of discomfort after drug administration;
- - redness and swelling of the mucous membrane of the vagina or external genitalia;
- arterial hyperemia and itching of the vulva .
In case of accidental oral ingestion of a pharmaceutical product, there will be no adverse effects.
Ginoflor E, application instruction (Way and dosage)
Instructions on candles Gynoflor E prescribes to deeply insert vaginal tablets into the vagina. It is recommended to carry out the manipulation in the evening, before going to bed, since the absorption capacity of the body is much higher at night. For ease of use, the tablets are injected in the supine position, with a slight bend of the legs at the knees - thus the inlet of the female genital organs is as open as possible, and therefore the use of the drug practically does not cause discomfort.
The course of conservative therapy differs based on the indications for drug treatment:
- For restoration of normal microflora of the internal environment of the vagina and a proliferating effect on the epithelium, 1-2 tablets are used daily for 6-12 days. More precise recommendations should be obtained from the attending physician, since they depend on various parameters of the body and the type of pathology.
- When treatment of atrophic lesions during the period and postmenopausal the dosage of the drug is reduced to 1 tablet daily for 6-12 days. Further, maintenance therapy is carried out with an even smaller amount of a pharmaceutical preparation - 1 tablet is used 1-2 times a week. The duration of the first therapeutic phase is determined by the doctor according to the individual level of hormones during the period of conservative sanitation.
For the duration of treatment with the pharmaceutical preparation Gynoflor, it is recommended refrain from intercourse or regularly use, so that the therapeutic effect of the drug is not reduced by the exogenous intake of pathogenic or opportunistic microflora.
Overdose
No cases of drug overdose have been recorded in clinical practice.
Interaction
Lacto acidophilic bacteria , which are one of the main components of the drug, are extremely sensitive to a wide range of , therefore, conducting antibiotic therapy of a local or systemic nature significantly reduces the effectiveness of the use of a pharmaceutical preparation.
Terms of sale
Gynoflor E is released only on a signed receptor form.
Storage conditions
The pharmaceutical preparation Gynoflor should be stored in a dry place, out of the reach of children and in direct sunlight, at a temperature of 2-8 degrees Celsius (in no case should the drug be frozen, because this will lose all the pharmacological properties of the constituent components).
A short storage of Gynoflora (no more than two weeks) at a temperature of 15 to 25 degrees Celsius will not lead to a decrease in its therapeutic effectiveness.
Shelf life
special instructions
The constituent components of the Gynoflor E preparation can not completely dissolve under the influence of internal factors of the vagina. In this case, the remains of the vaginal tablet can be found on the underwear or bedding, however, this does not affect the effectiveness of the drug (the remains are auxiliary substances that have fulfilled their pharmacological task).
In cases where it is noted vaginal dryness , you should wet the tablet before introducing it with a small amount of ordinary water in order to facilitate its faster dissolution. During the period of conservative treatment, women are advised to use pads if the candles are additionally wetted.
Gynoflor E does not affect the ability to concentrate for a long time, fine motor skills, coordination of movements and the ability to drive vehicles or other potentially life-threatening mechanisms.
Analogs of Gynoflor E
Matching ATX level 4 code:The normal microflora of the internal environment of the vagina is an extremely important parameter of the physiological functioning of the female genital organs, therefore Gynoflora analogues constitute a large group of pharmaceutical parameters, which includes both suppositories and tablets for intravaginal use.
As a rule, with individual contraindications, the therapeutic effect of the drug is replaced by the following drugs: Laktogin or Lactowag .
Synonyms
With alcohol
Alcoholic beverages do not in any way affect the therapeutic effects of the pharmaceutical preparation, and therefore the use of alcohol is not prohibited during the course of conservative treatment.
During pregnancy and lactation
The constituent components of Gynoflor do not have embryotoxic ,terato- or mutagenic action on the development of the fetus, because the drug is allowed to be used during pregnancy and breastfeeding (lactation). However, to carry out conservative therapy in first trimester recommended only under the constant supervision of qualified medical personnel and regular diagnostic tests.
Ginoflor E: instructions for use and reviews
Latin name: Gynoflor E
ATX code: G02CX
Active substance: lactobacillus acidophilus (lyophilisate) and estriol
Manufacturer: Medinova Ltd. Switzerland for LLC "Invar", Russia
Description and photo update: 22.10.2018
Gynoflor E is a combined drug for regulating the balance of the vaginal microflora.
Release form and composition
The dosage form of the drug is vaginal tablets: oval, biconvex, from light beige to white, inclusions are allowed (6 pcs. In blisters; in a cardboard box 1 or 2 packages).
Composition for 1 tablet:
- active ingredients: acidophilic lactobacilli (in the form of lyophilisate) ≥ 100 million viable bacteria - 50,000 μg; estriol - 30 mcg;
- auxiliary ingredients: lactose monohydrate, sodium carboxymethyl starch, magnesium stearate, microcrystalline cellulose, sodium dihydrogen phosphate.
Pharmacological properties
Pharmacodynamics
The composition of Ginoflor E contains as active ingredients: a short-acting female sex hormone of the estrogen class - estriol; live bacteria that dominate the vagina of a healthy woman, possessing antagonistic activity against a wide range of pathogenic and opportunistic microflora, supporting and normalizing the vaginal biocenosis - lactobacillus acidophilus.
Estriol has a protective trophic effect on the vaginal epithelium and does not affect the woman's body systemically. The mature proliferating epithelial layer of the vagina accumulates glycogen, which is necessary for the functioning of lactobacilli, which produce lactic acid to maintain the acidic environment of the vagina (pH 3.8-4.5), as well as create unfavorable conditions for the development and colonization of pathogenic microflora. Together with lactic acid, acidophilic lactobacilli produce bacteriocins and hydrogen peroxide, which also act depressingly on the development of pathogenic and conditionally pathogenic microflora.
Modification of the normal physiological environment of the vagina can occur due to the use of antibacterial agents of local or systemic action for the treatment of vaginal infections or systemic diseases, as well as if personal hygiene is not followed. In such cases, a significant decrease in the number of natural lactobacilli is likely. With intravaginal application, Gynoflor E normalizes the state of the vaginal epithelium and restores its natural microflora. Contained as a filler in vaginal tablets, lactose can be fermented by lactobacilli into lactic acid.
In case of hormonal disorders, the epithelial layer of the vagina can become thinner and damaged, therefore Gynoflor E is also recommended for use in postmenopausal women to relieve its local symptoms: itching, burning, dryness in the vagina, pain during intercourse. The drug helps to normalize the state of the epithelium of the vagina and urethra, reduces the frequency of degenerative inflammatory processes.
In vitro studies have shown that acidophilic lactobacilli reduce the pH to normal within a few hours. Estriol, when treated with a course of 6–12 days, provides a proliferative trophic effect on the epithelial layer of the vagina.
Pharmacokinetics
When the Gynoflor E tablet is introduced into the vagina, lyophilized acidophilic lactobacilli and estriol are released.
The study of the absorption of estriol from Gynoflor E was carried out with the use of the drug by women in the postmenopausal period. The plasma concentration of estriol after repeated use corresponds to the level of endogenous unbound estriol. After 12 days of treatment with vaginal tablets Gynoflor E, provided they are used once a day, the maximum concentration (Cmax) in the blood plasma of unbound estriol does not differ from the initial one, which is an indicator of the absence of systemic absorption.
The use of the drug does not affect the plasma concentration of the sex hormones present in the woman's body - estrone and estradiol, since estriol is the final product of their metabolism.
Indications for use
According to the instructions, Gynoflor E is recommended for use to restore normal vaginal microflora after the use of antibiotics and other antimicrobial drugs for local / systemic treatment of vaginal infections (bacterial vaginosis, non-specific vulvovaginitis), urogenital infections and sexually transmitted diseases. In the postmenopausal period, the drug is used in combination with hormone replacement therapy (HRT) for estrogen-dependent atrophic vaginitis.
Contraindications
- vaginal bleeding of unknown etiology;
- malignant estrogen-dependent tumors, including neoplasms of the mammary gland, ovaries, uterus or vagina (in history, diagnosed, as well as if they are suspected);
- endometriosis (suspected / diagnosed);
- untreated endometrial hyperplasia;
- increased individual sensitivity to any component of the drug.
Gynoflor E is contraindicated for use before the onset of sexual activity.
Instructions for the use of Gynoflor E: method and dosage
The tablets are intended for intravaginal (deep) administration. The procedure is recommended to be carried out in the evening, before going to bed, preferably in the supine position, with the legs slightly bent at the knees.
Dosing regimen according to indications:
- restoration of the normal microflora of the vagina: inject 1-2 tablets daily, the course is 6-12 days;
- treatment of estrogen-dependent atrophic vaginitis in the postmenopausal period: administer 1 tablet daily, course 6-12 days; maintenance dose - 1 tablet 1-2 times a week.
Side effects
When using Gynoflora E in the vagina, a burning sensation is possible, in rare cases - redness of the vulva and vagina and vulvovaginal itching.
Overdose
There is no data.
special instructions
The composition of Gynoflor E contains components that cannot dissolve without a trace, therefore, sometimes you can find remnants of a vaginal tablet on your underwear. This fact does not affect the effectiveness of the drug.
In exceptional cases, with excessive vaginal dryness, the tablet may not dissolve. To prevent such a situation, it can be moistened with a small amount of plain water before administration - this will facilitate faster dissolution. During therapy, patients are advised to use sanitary pads.
Influence on the ability to drive vehicles and complex mechanisms
The use of Gynoflora E does not affect the ability to drive vehicles and complex mechanisms.
Application during pregnancy and lactation
No undesirable effects of lactobacilli and estriol on the course of pregnancy and the condition of the fetus / newborn were found. But long-term clinical studies on the effect of estriol on the fetus have not been conducted.
It is undesirable to use Gynoflor E in the first trimester of pregnancy. Allowed therapy with the drug in the II-III trimesters of pregnancy and during breastfeeding, after consultation with a specialist.
Drug interactions
The simultaneous use of Gynoflora E with antibacterial drugs is not recommended, since acidophilic lactobacilli are sensitive to most antibacterial medicines for local or systemic therapy. Their simultaneous use can significantly reduce the effectiveness of treatment.
Analogs
Analogs of Ginoflor E are: Vagisan, Vagilak, Vaginorm-S, Laktogin, Laktovag, Ekofemin, etc.
Terms and conditions of storage
Store at 2–8 ° С. Do not freeze. Keep out of the reach of children.
The shelf life is 3 years.
pharmachologic effect
Both active substances that make up the preparation Gynoflor E, estriol and lactobacillus Lactobacillus acidophilus are involved in the physiological mechanism of maintaining normal vaginal biocinosis.
Lactobacillus acidophilus- one of the dominant microorganisms of the vagina of a healthy woman with antagonistic activity against pathogenic and opportunistic microorganisms.
Estriol - is a short-acting estrogen, has a protective trophic effect on the vaginal epithelium and does not have a systemic effect on the woman's body. The proliferating mature vaginal epithelium accumulates glycogen, which is necessary for the functioning of lactobacilli, which, in turn, produce lactic acid, maintaining the acidic environment of the vagina (pH 3.8-4.5), which creates unfavorable conditions for the colonization and development of pathogenic microorganisms. In addition to lactic acid, Lactobacillus acidophilus produce hydrogen peroxide and bacteriocins, which also inhibit the development of pathogenic and opportunistic microorganisms.
A change in the physiological vaginal flora occurs due to various factors: local or systemic use of antibacterial drugs, incl. due to vaginal infections, systemic diseases, non-compliance with hygiene rules. In these cases, the number of lactobacilli can be significantly reduced. Intravaginal application of Gynoflora E improves the condition of the vaginal epithelium and restores its normal flora. Lactose, which is found in vaginal tablets as a filler, can also be fermented by lactobacilli into lactic acid.
The vaginal epithelium becomes thinner and can be damaged by hormonal disorders, and therefore Gynoflor E can be used in postmenopausal women, weakening its local symptoms (itching, burning, dryness in the vagina, soreness during intercourse), contributing to the normalization of the state of the epithelium of the vagina and urethra, reducing the frequency of dystrophic inflammatory conditions.
It has been shown in vitro that Lactobacillus acidophilus leads to the necessary decrease in pH within several hours, and estriol, with a treatment duration of 6-12 days, provides a proliferative trophic effect on the vaginal epithelium.
Pharmacokinetics
When the drug is injected into the vagina, lyophilized bacteria and estriol are released.
The absorption of estriol from Gynoflor E has been studied in postmenopausal women. After repeated use of the drug, its plasma concentration corresponds to the concentration of endogenous unbound estriol. After the 12th day of using vaginal tablets in the course of treatment with Gynoflor E (1 time per day), the maximum concentration of unbound estriol in the blood plasma does not differ from the initial one, which indicates the absence of systemic absorption.
The use of the drug does not affect the concentration of estrone and estradiol in the blood plasma, since estriol is the end product of their metabolism.
Indications
- restoration of the flora of Lactobacillus acidophilus after local and / or systemic treatment with antibiotics or other chemotherapeutic agents;
- estrogen-dependent atrophic vaginitis in postmenopausal women, including in combination with hormone replacement therapy (HRT);
- bacterial vaginosis.
Dosage regimen
Vaginal tablets must be inserted deep into the vagina in the evening before going to bed, preferably in the supine position, with the knees slightly bent.
To restore the flora of Lactobacillus acidophilus after local and / or systemic treatment with antibiotics or other chemotherapeutic agents, as well as in the treatment of bacterial vaginosis: 1-2 vaginal tablets daily for 6-12 days.
In the treatment of estrogen-dependent atrophic vaginitis in postmenopausal women: 1 vaginal tablet daily for 6-12 days, then the maintenance dose is 1 vaginal tablet 1-2 times a week.
Side effect
Perhaps a burning sensation (heat) in the vagina, rarely redness and itching of the vulva and vagina.
Contraindications for use
- hypersensitivity to the drug or its components;
- malignant estrogen-dependent neoplasms, incl. mammary glands, uterus and vagina (diagnosed, in history, and if suspected);
- endometriosis (suspected or diagnosed);
- bleeding from the vagina of unclear etiology;
- use in girls before the onset of sexual activity;
- untreated endometrial hyperplasia.
Application during pregnancy and lactation
Use in the first trimester of pregnancy is undesirable. It is possible to use the drug Gynoflor E in the II-III trimesters of pregnancy and during lactation. No undesirable effects of lactobacilli and estriol on pregnancy and the condition of the fetus / newborn were found. However, long-term clinical studies on the effect of estriol on the fetus have not been conducted.
Application in children
Contraindicated for use in girls before sexual activity.
Overdose
No drug overdose was observed.
Drug interactions
Lactobacillus acidophilus is susceptible to numerous antibacterial drugs (topical or systemic). Concomitant treatment with such agents can lead to a decrease in the effectiveness of Gynoflor E.
Terms of dispensing from pharmacies
Without recipe.
Storage conditions and periods
Store at 2 to 8 ° C. Do not freeze! Keep out of the reach of children. The shelf life is 3 years.
special instructions
Gynoflor E contains components that may not completely dissolve; the remnants of a vaginal tablet can sometimes be found on underwear. This does not affect the effectiveness of the drug.
In isolated cases, with vaginal dryness, the vaginal tablet may not dissolve. To prevent such cases, before administration, the tablet can be moistened with a small amount of ordinary water - this will facilitate its faster dissolution. Patients are advised to use pads.
Influence on the ability to drive a car and other mechanisms
Gynoflor E does not affect the ability to drive vehicles and mechanisms.
Gynoflor vaginal tablets have antimicrobial activity, restore the normal microflora of the vagina, and relieve thrush. The active ingredients are the components - estriol and lyophilisate of acidophilic lactobacilli. The last ingredient belongs to the eubiotic group. Auxiliary components - lactose monohydrate, magnesium stearate, microcrystalline cellulose, etc. Gynoflor analogs are represented by drugs: Vagisan, Laktovag, Ekofemin, Geksikon, Betadin.
Mechanism of action and indications for use
The components of the drug are enclosed in biconvex tablets, each containing 50 mg of the active ingredients. The substances contained in the suppositories are part of the physiological mechanism that helps maintain the full-fledged microflora of the vagina. The main purpose of using the drug is to destroy fungal microorganisms, restore the biocenosis of the vagina.
Lactobacilli are a key fraction of microorganisms that live in the vagina of every healthy woman. They are characterized by medicinal activity against pathogenic microorganisms. Also, bacteria help to restore the balance of the physiological environment, which eliminates the possible violation of metabolic processes.
Estriol is a synthetic component, its chemical structure is similar to the female sex hormones, which are produced by the ovaries. Thanks to the therapeutic effect of the substance, there is an increase in the natural barrier against infections of various origins.
After the introduction medicinal product, the constituent funds are released gradually, disintegrate under the influence of internal factors.
For your information, lactobacilli have only a local effect, are not absorbed into the systemic circulation, which nullifies the likelihood of systemic side effects.
The indications for use of the drug are extensive. It is primarily recommended for the treatment of thrush in women. Appropriate appointment in the following situations:
- Restoration of full-fledged microflora of the vagina after antibiotic therapy;
- Bacterial candidiasis and vaginosis therapy;
- Nonspecific form of vulvovaginitis;
- Urogenital diseases of various etiologies;
- Atrophic form of vaginitis;
- Therapy of bacterial secretions of unknown pathogenesis;
- As part of the complex treatment of various diseases.
Vaginal tablets begin to work 1-2 hours after administration. Quickly relieve thrush. In accordance with the instructions for use, it is permissible to use them as a preventive measure for a fungal infection.
Contraindications and side effects
Gynoflor suppositories have not only indications for use, but also contraindications. In a situation where they are present, the patients prescribe analogues of the drug "Gynoflor E".
It is impractical to apply in the following situations:
- Organic sensitivity to medicinal components. Congenital or acquired intolerance to the drug as a whole or to certain substances.
- If a history of malignant neoplasms is diagnosed, which are dependent on the concentration of estrogen. In particular, they are not prescribed if the pathology is localized in the area of \u200b\u200bthe mammary glands, uterus, ovaries.
- Endometriosis is the proliferation of uterine tissue beyond its limits.
- Discharge of a hemorrhagic type of unknown etiology.
- Virginity.
According to reviews, tablets for vaginal administration quickly help get rid of the symptoms of thrush. Rarely does anyone complain about development side effects... However, they need to be considered:
- Burning, itching after drug administration;
- Feeling of a foreign body in the vagina or other kind of discomfort;
- An allergic reaction is redness and swelling of the mucous membrane of the internal or external genital organs.
The likelihood of developing side effects is less than 0.5%. Except if the tablet gets inside. An overdose of medication is impossible, there is no data on this.
Important: lactobacilli, which are the active substance of the drug, are extremely susceptible to antibiotic therapy. Therefore, the simultaneous use of antibiotics and the introduction of suppositories significantly reduces the therapeutic efficacy of vaginal tablets.
Instructions for use
Vaginal tablets are available over the counter. The price for 12 pieces is about $ 18. Some similar drugs will cost slightly less. In accordance with the instructions, the pill is inserted as deep as possible into the vagina.
It is better to administer the medicine in the evening just before bedtime. Since the absorbent property of the drug increases at night. To make it comfortable, a woman is recommended to sit on her back, slightly bend her knees - this allows you to maximally open the inlet of the female genital organs, respectively, the introduction of the drug will be carried out without severe discomfort.
The duration of the therapeutic course, dosage and frequency of application are due to the reason for the appointment:
- Treatment of thrush begins 3-6 days after the end of the menstrual cycle. Usually the doctor recommends the introduction of one or two tablets per day. The duration of the course varies from 7 to 14 days. The exact treatment regimen is prescribed taking into account the severity of the fungal disease and other factors.
- To restore normal microflora, 1-2 vaginal tablets are used every day. Duration of treatment is 6-12 days. In some cases, the course is extended if the patient has an advanced form of the disease.
- For the treatment of atrophic lesions during menopause, one tablet is prescribed every day. The course of treatment is similar to the options described above. Then supportive treatment is carried out, implying the introduction of one tablet no more than twice a week. The time of the first phase of treatment is determined on an individual basis, depending on the concentration of hormones in the woman's blood.
During the treatment of thrush, it is necessary to abstain from sexual activity or use barrier contraceptives every time you have intercourse. However, doctors agree that it is better to give up sex in order to exclude a possible decrease in the effect of drug therapy.
If a woman has severe vaginal dryness, then before inserting a candle, it is dipped in plain water, which contributes to a faster dissolution. During therapy, it is necessary to use pads, since some of the components leak out. This does not affect the therapeutic outcome.
Analogs of vaginal tablets Gynoflor
Thrush causes a lot of discomfort, significantly reduces the quality of life, manifests itself with alarming symptoms - itching, burning, painful sensations during intercourse, vaginal discharge. If the tablets are not suitable due to the existing medical contraindications, then analogs of "Gynoflor E" are recommended:
- Vagisan is a medicine for thrush, available in the form of tablets for oral administration, capsules for vaginal administration. Cannot be used with personal sensitivity to the composition. Recommends the administration of one tablet per day. The course of treatment is one week. Start treatment after the menstrual cycle. There are no data on overdose. Side effects are extremely rare;
- Lactonorm - suppositories, help to restore the normal microflora of the vagina, contribute to the destruction of fungi, which allows you to cure thrush. Application - 1 candle 2 times a day. The course of therapy is a week. The drug interacts with any form of drugs, this does not affect its therapeutic effectiveness;
- Betadine helps to get rid of thrush, it is not a structural analogue of the drug Gynoflor. The main active ingredient is povidone iodine. Vaginal suppositories have antiseptic and antimicrobial effects. The course of treatment: 1 suppository every 24 hours for 7 days. Contraindications: hyperthyroidism, Duhring's dermatitis, simultaneous use of radioactive iodine, organic intolerance;
- Pimafucin is a high-quality antibiotic with antifungal properties, based on the substance natamycin. It is permissible to use while carrying a baby and breastfeeding. There are no toxic components in the composition. Already after the first application, alarming symptoms subside;
- Terzhinan has a detrimental effect on opportunistic fungi. It has antibacterial, anti-inflammatory and antifungal properties. One tablet is administered per day before bedtime. Recommended with extreme caution in the first trimester.
During pregnancy and lactation, therapy should be approached with caution. All medications are prohibited in the first trimester, many are not recommended for lactation, as substances pass into breast milk.
Thrush is an extremely unpleasant disease that has a tendency to recurrent course. Only adequate treatment and the right drug help you forget about negative symptoms forever. Self-treatment is fraught with the "return" of the disease with renewed vigor.