The effectiveness of the drug
The most effective antiviral drug currently used is oseltamivir.
As an inhibitor of the neuraminidase enzyme, it acts on one of the viral replication links, which leads to its death. The drug is a representative of the third generation of this group. The previous medication, zanamivir, can only be used as a nasal spray, and even then with large side effects that limit its intake. The developers tried to avoid these disadvantages with oseltamivir.
- A little excitement.
- Abnormal behavior.
- Confusion.
If you experience an allergic reaction or unexpected skin rash while taking this medication. Extreme weakness or fatigue.
- Yellowing of the skin or in white light.
- Loss of appetite.
- Severe abdominal pain.
- Brown urine as well as pale stools.
Oseltamivir ( tradename Tamiflu), is produced by a Swiss pharmaceutical company. He passed serious repeated tests with the USA, Holland, Great Britain, Asian countries, conducted both on animals and on humans. Sufficient part scientific works is devoted to the study of the effect of the drug on birds infected with the H1N1 virus. The results of these experiments are very encouraging, which made it possible to classify Tamiflu as a drug with proven efficacy against the influenza virus.
When prescribing Tamiflu treatment, it is important to report any other diseases, medications, allergies, heart problems, severe respiratory problems, immunosuppression, kidney problems to the doctor. It is absolutely imperative for women to report pregnancy along the way so as not to risk compromising fetal health.
All this can interfere with the effect of drugs, and then it will be necessary to adjust the doses and conduct careful medical supervision. It is equally important to report alcoholism or any other addiction to drugs or substances considered harmful to health.
Studies show that the use of the drug reduces the average duration of the disease by 30-40%, by the same amount - the severity clinical manifestations him. The risk of developing complications of influenza decreases by 1.5 times, and the number of deaths among elderly patients decreases by the same amount. All these data indicate great prospects for the drug for the treatment of influenza.
It is possible that interactions between the active ingredients of Tamiflu and other drugs may occur. Therefore, you need to be careful and report to the doctor all medications that you are taking before starting this treatment. Indeed, here is a list of drugs and active ingredients that can negatively affect Tamiflu.
Abnormal renal elimination resulting in: chlorpromamide, methotrexate, phenylbutazone.
- Clopidogrel.
- Probenecid.
- Amoxicillin.
- Evaporated influenza vaccine.
It is most effective when taken within the first 48 hours after the onset of the disease.
However, there is positive data on its use in more late dates, and also with good effect.
disadvantages
The significant disadvantages of oseltamivir as a drug for influenza include its narrow spectrum of action, which allows the drug to be used only with influenza A and B viruses, that is, only during an epidemic when the pathogen has already been confirmed by laboratory. Given its mechanism of action, the drug may be ineffective at the prophylaxis stage, although the manufacturers are very optimistic here and offer the necessary treatment regimens for this.
Tamiflu is not an alternative to the influenza vaccine, it is necessary to continue vaccination every year until the expected period of the epidemic. Tamiflu treatment should be used only when a specialist doctor diagnoses the circulation of the virus in the human metabolism. In some cases, it can be used as a preventive treatment, such as when the person at risk is in direct contact with a sick person.
On the other hand, be aware that your doctor may require you to prescribe Tamiflu for other health problems that are not related to the flu. However, no scientific study has yet proven the effectiveness of this treatment, beyond its positive effects on influenza infections.
A significant drawback of oseltamivir for influenza is its price. Despite the fact that since 2009, when it began to be actively used during the epidemic, the price of the drug has decreased by 3 times, it is still high and amounts to about 1,000 rubles for 10 capsules.
Side effects
The drug is available in the form of capsules and powder for preparing a suspension, which allows it to be used in children after a year, thereby expanding the scope. Compared to its predecessor, zanamivir, side effects are less pronounced. However, it is possible
Where to buy Tamiflu and at what price?
You can of course purchase this flu therapy at any physical pharmacy as long as you submit a prescription from a healthcare professional. It is also possible to buy Tamiflu online, where prices are usually lower. Our teams recommend a processed online platform that has all the necessary certifications for your safety.
Form, composition, description of the medicinal product
By ordering flu treatment from this online pharmacy, you will be able to get your medication within 24 hours, plus a free and valid prescription from your doctor. To do this, simply fill out a detailed questionnaire directly on their website, the doctor will analyze your answers on a trace and then provide you with a certified medical prescription.
- the development of allergic reactions;
- dyspeptic disorders (nausea, vomiting, diarrhea);
- nervous disorders (dizziness, headache, sleep disturbance, convulsions);
- cough, sore throat, difficulty breathing, up to bronchospasm.
The instructions for oseltamivir for influenza indicate that the drug is contraindicated in patients with severe renal dysfunction, in the presence of allergic reactions to the components of the drug.
Indications: why count?
Tamiflu is a capsule formulation based on oseltamivir. Fillers Content of capsules: starch Talc Povidone Croscarmellose sodium Stearic fumarate sodium Capsule wrapping: Gelatin Iron oxide Iron oxide Titanium dioxide Typical ink: Shellac Titanium dioxide Indigotin. Influenza with flu symptoms Preventive prevention of influenza Seasonal prevention of influenza. On the active principles of Oseltamivir. ... Tamiflu is indicated in adults and children, including newborns, with symptoms typical of influenza during the circulation of the virus.
During pregnancy and lactation, it can be used with great care.
To the same group medicines Arbidol, a Russian-made drug, is very actively advertised by the media and official sources. The constant availability of Arbidol in the pharmacy chain and its affordable price make it competitive in comparison with Tamiflu. 
"Zanamivir": patient reviews
Efficacy was demonstrated when treatment was started within 2 days of symptom onset. Postoperative prophylaxis: in subjects one year of age or older after exposure to clinically diagnosed influenza during the period of viral circulation.
Antisymptomatic medicines
The appropriate use of Tamiflu in the prevention of influenza should be determined on a case-by-case basis depending on the circumstances and the population to be protected. In exceptional cases, seasonal prophylaxis may be considered in individuals one year of age or older.
However, the main criterion, the effectiveness of the drug, is an unproven fact, since there is no reliable information about the tests conducted.
Nevertheless, there are often positive reviews about the use of arbidol as a medicine for influenza.
Choice medication with flu, it should be done quickly and directly by the attending physician, who will prescribe the drug based on the general condition of the patient, as well as data on the epidemiological situation and the alleged pathogen.
Tamiflu is indicated for post-exposure prophylaxis of influenza in an influenza pandemic. Tamiflu is not an alternative to influenza vaccination. Using antiviral drugs for the treatment and prevention of influenza should be determined on the basis of official guidelines.
Against testimony: why not accept it?
Hypersensitivity to the active substance or any of the excipients listed in the composition. Tamiflu capsule preparations and oral suspension are bioequivalent, doses of 75 mg can be administered either by administration. One 30 mg capsule plus one 45 mg capsule or.
During the period of epidemics and colds, which are more common in the cold season, people use all sorts of ways to increase immunity. Some use old and proven recipes for this. traditional medicine... Others resort to medicinal formulations. The opinions of doctors about such prevention are very different.
A dose of 30 mg plus a dose of 45 mg of a suspension. The commercially available form of Tamiflu powder for oral suspension is the preferred form for children and adults who have difficulty swallowing capsules or when lower doses are required.
Adults and adolescents aged 13 and over. Treatment: The recommended dose of oseltamivir is 75 mg twice daily for 5 days by mouth for adolescents and adults. Prophylaxis after exposure: The recommended dose for prophylaxis against influenza after close contact with an infected person is 75 mg oseltamivir once daily for 10 days for adolescents and adults.
This article will tell you about the reviews of Zanamivir. You will learn about the trade names of this medicine and can read the reviews about them.
Preparations containing zanamivir
In modern pharmacy chains you can buy a medicine with the trade name "Relenza". Recently, it has been released only as prescribed by a doctor. However, unscrupulous sellers can give it away without a corresponding piece of paper.
Treatment should begin as soon as possible within two days of contact with an infected object. The recommended dose for the prevention of influenza during the epidemic period is 75 mg of oseltamivir once daily for 6 weeks of treatment. Tamiflu 30 mg, 45 mg and 75 mg hard capsules and oral suspension are available for infants and children one to 12 years of age.
Treatment: For infants and children one year of age and older, the following weight-adjusted dosages are recommended. Treatment should begin as soon as possible within the first two days after the onset of flu symptoms. Postexposure prophylaxis: the recommended dose of Tamiflu in post-exposure prophylaxis.
Many consumers are wondering if there are other drugs available that contain zanamivir? We can confidently answer this question in the negative. Drug manufacturers have not yet created an absolute substitute for this drug.
general characteristics
What the drug "Zanamivir" has reviews, you can find out further. To begin with, it is worth giving a description of this drug. As you already know, the trade name of the drug is "Relenza". The composition is available in powder form. It is used exclusively by inhalation. Internal use is unacceptable and contraindicated.
Epidemic prevention: Prevention of influenza during an epidemic has not been studied in children under 12 years of age. This is based on pharmacokinetic and safety data suggesting that this dose in children 0 to 12 months of age results in plasma prodrug and active metabolite concentrations expected before clinical efficacy and tolerability comparable to those in older children and adults. The following dosages are recommended for children aged 0-12 months.
Are there analogues of Tamiflu?
Postexposure prophylaxis: The recommended dose for prophylaxis in children under one year of age in an influenza pandemic is half the daily dose for treatment. This is based on clinical evidence in infants and children 1 year of age or older and adults showing that a prophylactic dose equivalent to half the daily dose for treatment is clinically effective in preventing influenza. For prophylaxis in infants aged 0 to 12 months, the following dose is recommended. depending on age.
The preparation contains 20 doses. Each contains 5 milligrams of zanamivir. Also among the additional substances can be noted lactose. In the kit for the drug "Zanamivir" instructions are required. Also in the package there is a device for inhalation administration of the drug. The way to use it is described in the annotation in sufficient detail.
Oseltamivir: side effects
This dosage recommendation is not intended for premature infants, i.e. infants less than 36 weeks of age post-denominational. The available data are insufficient for these patients, for whom different doses may be required due to the immaturity of their physiological functions.
Epidemic prevention: Epidemic prevention has not been studied in children aged 0-12 months. In the section Instructions for use, handling and disposal. No dose adjustment is required for the treatment or prevention of patients with impaired liver function. No studies have been conducted in children with hepatic impairment.
Drug cost
What is the price for the drug with the active ingredient zanamivir? It all depends on where you will buy the medication. In drugstore chains that dispense a remedy according to a corresponding prescription, the drug costs about 1,300 rubles per pack. In the event that you do not have a prescription from a doctor, pharmacists can raise the price up to 2,000 rubles for their own benefit and release the goods to you. Such situations have been reported many times.
Method of using the medication
Flu treatment: Dosage adjustment is recommended for adults and adolescents with moderate to severe renal impairment. Recommended doses are described in the table below. Influenza Prevention: Dosage adjustment is recommended for adults and adolescents with moderate to severe renal impairment, as described in the table below.
Negative reactions: side effects
The purification of oseltamivir carbonate is usually higher with the method. Automatic peritoneal dialysis. Nephrologist's assessment. The clinical data available in infants and children with renal insufficiency are insufficient to make a dose recommendation. No dose adjustment is required except in moderate or severe renal impairment.
Also, some consumers say that the price for the drug "Zanamivir" is about 3-5 thousand rubles. In this case, the medication is ordered via the Internet. Such manipulation does not require a prescription, but it is completely illegal. Please note that medicinal formulations must be purchased exclusively from the relevant points that are licensed and authorized to sell them. Treatment with low-quality medicines purchased in clandestine centers can lead to disastrous consequences.
Tamiflu and Russian flu drugs - doctor's review
Longer treatment times for seasonal prophylaxis, up to 12 weeks, have been evaluated in immunocompromised patients. Symbols are printed in blue. Although there have been no controlled clinical studies on the use of oseltamivir in pregnant women, limited data on reported cases after commercialization and retrospective follow-up are observed. Pregnant women can receive Tamiflu after taking into account the available information on the safety of use, the pathogenicity of the circulating viral strain of the influenza virus and the presence of an underlying condition.
How to replace the drug?
The active ingredient is different. As you already know, there is no absolute substitute for the drug that would have an identical composition. However, there are remedies with another active ingredient that works in the same way. The closest medicine to the one described will be Tamiflu. Zanamivir and oseltamivir are both neurominidase inhibitors. They block the release of harmful particles from cells that are already infected by the virus. Note that the active ingredients zanamivir and oseltamivir are unique. They have no analogues with the same composition. Tamiflu is available in tablets for internal use and cannot be inhaled.
The active ingredient is zanamivir analogs and another plan. These drugs include "Interferon", "Isoprinosin", "Rimantadin", "Anaferon", "Derinat", "Isoprinosin" and many others. They all have a lower cost. At the same time, they are available for sale without appropriate appointments from a doctor. The listed medicines can be in the form of tablets, injections, drops for nasal administration and inhalation.
Indications for appointment
As you already know, the active ingredient zanamivir (Relenza) is sold exclusively by prescription. In this case, the physician should prescribe medications for you. The doctor writes out a form, which indicates the amount of the drug and the duration of the course of use. Your data (surname and first name) must also be entered. According to this document, you can freely purchase the specified tool.
The medicine "Zanamivir" ("Relenza") is used as an antiviral and immunomodulatory agent. It is used for treatment and prophylaxis. The annotation indicates that powder for inhalation is prescribed for A and B. At the same time, doctors sometimes recommend a medication in other situations. The medicine can be used for viral bronchitis, pneumonia and other diseases.
Restrictions on use
About the medicine "Zanamivir" the instruction informs that it should not be used in case of hypersensitivity to the components of the drug. The composition is not prescribed for diabetes and lactase deficiency. This is where the funds run out.
However, doctors have a slightly different point of view on this matter. They supplement the described data with others. About the "Zanamivir" tool, experts say that the medicine should not be used by children under the age of 5 years. All due to the fact that the baby will not be able to take the drug correctly. Also, in the specified tool it is impossible to divide the available dose into several parts.
additional information
Can Tamiflu and Zanamivir be used during pregnancy and lactation? As you already know, medicines are contraindicated in young children. So can they harm the baby through the body of his mother? Let's look at this issue.
The annotation indicates that you should not use the described medicine in the first trimester of pregnancy. In the second and third parts of the term, use is permissible only as directed by a doctor, taking into account all the risks. Doctors have a different opinion. About the medicine "Zanamivir" (trade name - "Relenza") experts report the following. The introduction of the drug in large doses, as well as the use of an analogue of "Tamiflu", can affect the developing fetus. It is especially dangerous to use drugs in large doses.
Negative reactions: side effects
The active ingredient zanamivir (trade name of the drug - "Relenza") is usually well tolerated by consumers. However, the annotation says that the drug can cause side reactions.
The instructions describe the following cases:
- An allergic reaction manifested by a rash, itching and hives.
- A cough that leads to bronchospasm.
- Swelling of the face, larynx, difficulty breathing.
If you are faced with a similar situation, it is recommended that you contact a specialist as soon as possible. Further use of this medication is unacceptable and dangerous.
Method of using the medication
For the flu, "Zanamivir" is used by inhalation. The medication has no other way of using it. Many patients are interested in whether there are tablets with the name "Zanamivir"? This form of release of the medication is not yet available.
Before you start using, you must carefully read the instructions. Also, strictly follow all the recommendations given to you by your doctor. If there were none, then follow the annotation.
Take the inhalation container and examine it carefully. Remove the cover and insert one rotary disc. After that, snap the container and start inhalation. Depending on the purpose of the drug, its dose can vary greatly.
Flu treatment
Antiviral "Zanamivir" is prescribed for adult patients and children over five years old. In children, the use of the drug should be supervised by adults. The dosage of the drug is two inhalations twice a day. In this case, it is desirable to make the application at the same time with equal intervals.
One rotadisk is enough for a day of treatment. The duration of the course is 5 days. With the help of mathematical calculations, you can find out that the package of the medicine is enough for the whole course.
Preventive actions
The medicine "Zanamivir" is recommended as a prophylaxis. Recently, however, it has been used less and less. The reason for this was the sale of a prescription drug. Specialists try to prescribe for prevention viral diseases other, more affordable and safer means.
As a preventive measure against influenza and viral infections the medication is used in adults and children after 10 years. It is not recommended to use it earlier in the absence of a disease. The instructions for use advise you to follow the following algorithm. Two inhalations of 5 milligrams of active substance are carried out per day. In order not to get sick upon contact with an infected person, it is necessary to continue such therapy for up to 10 days. One pack of medication is just designed for this period.
Persons with respiratory diseases
The drug "Zanamivir" in rare cases leads to such a side effect as bronchospasm. However, this reaction is not excluded. It is especially susceptible to people who have a history of respiratory diseases. Most often these are asthmatics.
If it is not possible to refuse the described remedy, then it is necessary to have bronchodilator drugs with you for the entire duration of treatment. Do not think that if the reaction did not arise once, then it will not be there afterwards. With the development of bronchospasm, you must immediately stop the manipulation. Take an appropriate medicine as soon as possible to relieve bronchospasm and dilate the bronchus. This will help you regain normal breathing. During the procedure, breathe as you would in everyday life. You don't need to take very deep, harsh breaths.
"Zanamivir": patient reviews
What are the opinions of those who used it for treatment or prevention about the described medicine? Many people used this remedy during epidemics. More recently, it could be purchased without a doctor's prescription. Patients say that Zanamivir is very effective. The medicine quickly has a positive effect on the body. It boosts immunity and strengthens resistance. It should be said right away that the timely use of the drug after contact with an infected person does not allow a person to get sick.
Also, many patients used the drug to treat the disease. The drug is prescribed for such severe and dangerous diseases as swine or It is these diseases that often lead to complications and death. Consumers report feeling much better after starting therapy. An improvement in the condition was observed already on the second or third day. The general course of treatment was five days. In rare cases, the doctor recommended increasing the duration of the medication.
Patients testify that Zanamivir is convenient to use. You can always take your inhalation device and rotadisk with you. If you can't go on sick leave and have to go to work, then this will be an invaluable plus.
Experts' opinions
Often patients ask their doctor about Zanamivir, where to buy it? The specialist should always explain to his patient that this medication is dispensed exclusively by prescription. You should not look for workarounds and purchase the drug at non-specialized points. Doctors say that there were often cases of identifying adverse reactions from therapy not considered above. At the same time, the consumer used the clandestine method of purchasing a medicine. Nobody knows what is actually in such a preparation.
Therapists say that the remedy should not be used prophylactically. Currently, there are many alternative funds that are recognized as safer and more affordable. You can easily purchase them at the pharmacy and carry out a preventive course of admission. The medication "Zanamivir" is prescribed only when the disease has already been identified.
Some experts report that Zanamivir has no proven effectiveness. Doctors say that the drug's action is based on the placebo effect. However, the price of the medication and its instructions indicate otherwise. Of course, reviews are very important for specialists and consumers of the drug. However, you should not rely only on them. Doctors advise to study the information about the medicine before using it. But at the same time, be sure to read the instructions for use and take into account the opinion of doctors.
Is it addictive?
Experts say about the medicine Zanamivir that it is never addictive. Many consumers have misconceptions. They believe that viruses can develop resistance to the specified substance. After all, this is exactly what happens with uncontrolled or improper use of antibiotics.
In fact, this is not the case. This medicine affects its own immunity, strengthening it. The drug blocks the release of neurominidase. That is why it is called an inhibitor. The remedy after getting into airways recognizes the affected cells and inhibits their work. Also, the inhalation powder containing zanamivir prevents the virus from penetrating further. The maximum effect of the medication occurs when therapy is carried out in the first two days after the first symptoms of infection appear. This is usually a headache sharp rise body temperature. In this case, the flu is usually characterized by numbers from 39 degrees and above. Often, the patient is unable to eliminate the fever with the usual antipyretic drugs.
Interaction
Often Zanamivir is prescribed concurrently with other drugs. Most often, a combination of non-steroidal anti-inflammatory drugs with the specified medication is made. Such interaction is perfectly acceptable. There are no negative reactions to treatment. Together, the drugs have a positive effect on the patient's body, relieving inflammation, lowering the temperature and blocking the multiplication of the virus.
It so happens that sorbents are prescribed with the specified medication. They are used to flush out toxins that are secreted by multiplying viruses. With this combination of drugs, it is imperative to take a break. Doctors usually recommend taking one remedy and only after 2-3 hours resort to using another. Otherwise, it may not work to the full extent.
Prescription of the drug can be carried out simultaneously with antibiotic therapy. In this case, most of the antimicrobial compounds are normally combined with the indicated medicine. But it is worth remembering that with the simultaneous use of medicines, it is imperative to consult a doctor. If you have to take any drug and have been prescribed Zanamivir, tell your doctor. If necessary, your doctor will help you choose the most appropriate dosage regimen.
The medicine should not be used with other antiviral and immunomodulatory agents, unless the doctor gave such a recommendation. Such therapy can lead to an overdose of one or another active substance. Any incorrect combination of drugs is fraught with consequences.
Summarize…
You have learned about the drug Zanamivir. The drug has the trade name "Relenza". It is impossible to replace it with medicines with the same substance. Getting medicine without a prescription from a doctor is difficult and unsafe. Remember that drug restrictions are not created for nothing. In this way, the state tries to protect a person from improper treatment that can harm him.
In most cases, the specified medication has positive reviews. He has practically no contraindications. According to the instructions, the medicine effectively fights against different types of viruses. However, not all experts are convinced of the effectiveness of the drug. To this day, there are active disputes and research on this matter. To get a correct, effective and qualified appointment, you need to see a doctor. If necessary, the doctor will prescribe a series of tests for you, after which he will recommend one or another remedy. Remember that the flu is insidious disease... It often leads to complications that can be fatal. Do not hesitate and use well-known medications... Good health to you!