Magnesium is an element that the spectrum of physiological processes of the body cannot do without. It enters the bloodstream only with the food consumed, because the body is not able to produce magnesium on its own. This element desensitizes the body to environmental influences, relieving symptoms such as irritability and anxiety. The balance of magnesium in the body is not difficult at all to break.
The daily requirement of this trace element is difficult to replenish with the help of nutrition alone. By reducing the amount of fruits and vegetables in the diet, consuming sugar, salt and other refined foods, people increase the deficiency of magnesium in the body. However, all this is fixable with the help of pharmacy products, which include Magnistad or Magne B6.
Magnistad and Magne B6 - what are the differences?
Magnistad produced by the Russian pharmaceutical holding STADA CIS. Available only in tablet form.
Magne B6 Is a French medicine. Available in two forms:
- tablets
- solution in ampoules, taken orally - the difference from tablets lies in the increased dosage of the components and the additional presence of another form of magnesium (see table below).
Magnistad and Magne B6 tablet includes:
- magnesium lactate dihydrate (also find out which is better - magnesium lactate or citrate)
- pyridoxine hydrochloride
In addition to magnesium lactate, pyridoxine hydrochloride is present in both drugs. Pyridoxine belongs to the group of vitamin B - vitamin B6. It is one of the most important for the normal functioning of the nervous system and the musculoskeletal system. Participates in the exchange of amino acids, which are used for protein synthesis in the body. In a therapeutic dosage (as in the composition of Magnistad and Magne B6), it is designed to reduce cramps and numbness in the limbs, to reduce the number of nocturnal muscle spasms.
Magnesium and vitamin B6 mutually improve each other's absorption.
Magnistad or Magne B6 - which is better?
Due to the identical composition Magnistad and Magne B6 can be called analogues.
Taking Magne B6 or Magnistad is advisable if magnesium deficiency is accompanied by symptoms such as:
- heart palpitations;
- irritability;
- difficulty falling asleep and other sleep disorders;
- intestinal and stomach cramps;
- increased fatigue;
- muscle pain, cramps, and tingling sensation.
The average course of therapy with these drugs is approximately 1 month. Reception should be discontinued after stabilization of blood magnesium levels. These magnesium supplements taken on an empty stomach can cause diarrhea, so Magne B6 or Magnistad is best taken with meals.
With a slight magnesium deficiency (without the symptoms listed above), you can drink a course of vitamins with magnesium to inflame it.
It is difficult to say which is better - Magnistad or Magne B6, since the active substances contained in the first and second preparations are identical. The main selection criterion may be the price, because the cost of 50 Magne B6 tablets is almost 2.5 times higher than the cost of the same number of Magnistad tablets.
P N013203 / 01, P N013203 / 02.Trade name of the drug:
Magne B 6 ®.Dosage form:
film-coated tablets, oral solution.Composition
Film-coated tablets
Tablet core:
active ingredients:
magnesium lactate dihydrate * - 470 mg;
pyridoxine hydrochloride - 5 mg;
excipients: sucrose - 115.6 mg, heavy kaolin - 40.0 mg, acacia gum - 20.0 mg, carboxypolymethylene 934 - 10.0 mg, talc (magnesium hydrosilicate) - 42.7 mg, magnesium stearate - 6.7 mg.
Tablet shell: acacia gum - 3.615 mg, sucrose - 214.969 mg, titanium dioxide - 1.416 mg, talc (magnesium hydrosilicate) - traces, carnauba wax (powder) - traces.
* - equivalent to the content of magnesium (Mg ++) 48 mg
Oral solution
Active ingredients:
magnesium lactate dihydrate ** - 186 mg;
magnesium pidolate ** - 936 mg;
pyridoxine hydrochloride - 10 mg;
excipients: sodium disulfite - 15 mg, sodium saccharinate - 15 mg, cherry-caramel flavor - 0.3 ml, purified water up to 10 ml.
** - equivalent to the total content of magnesium (Mg ++) 100 mg
Description
oval biconvex tablets, coated white, with a smooth shiny surface.
Oral solution:
clear liquid brown with a caramel smell.
Pharmacotherapeutic group
Magnesium drug.
ATX code: A11JB.
Pharmacological properties
Pharmacodynamics
Magnesium is a vital element that is found in all tissues of the body and is necessary for the normal functioning of cells, participates in most metabolic reactions. In particular, it is involved in the regulation of the transmission of nerve impulses and in muscle contraction. The body gets magnesium from food. Lack of magnesium in the body can be observed in violation of the diet (diet) or with an increase in the need for magnesium (with increased physical and mental stress, stress, pregnancy, use of diuretics). Pyridoxine (vitamin B 6) is involved in many metabolic processes, in the regulation of the metabolism of the nervous system. Vitamin B 6 improves the absorption of magnesium from the gastrointestinal tract and its penetration into cells.
Serum magnesium content:
Absorption of magnesium in the gastrointestinal tract is no more than 50% of the oral dose. 99% of the magnesium in the body is found inside cells. Approximately 2/3 of intracellular magnesium is distributed in bone tissue, and the other 1/3 is in smooth and striated muscle tissue. Magnesium is excreted mainly in the urine. At least 1/3 of the dose of magnesium is excreted in the urine.
Indications for use
Established magnesium deficiency, isolated or associated with other deficiency conditions, accompanied by symptoms such as: increased irritability, minor sleep disturbances; gastrointestinal cramps or heart palpitations; increased fatigue, pain and muscle spasms, tingling sensation.Contraindications
Carefully
With a moderate degree of renal failure, since there is a risk of developing hypermagnesemia.
Application during pregnancy and lactation
Pregnancy
Clinical experience of using the drug in a sufficient number of pregnant women did not reveal any adverse effect on the occurrence of fetal malformations or fetotoxic effects.
Magne B 6 ® can be used during pregnancy only if necessary, on the advice of a doctor.
Breastfeeding period
Magnesium passes into breast milk. Avoid using the drug during lactation and breastfeeding.
Method of administration and dosage
Before taking the drug, you should consult your doctor.Film-coated tablets
Adults are advised to take 3-4 ampoules per day.
For children over 1 year old (body weight more than 10 kg), the daily dose is 10-30 mg magnesium / kg body weight (0.4-1.2 mmol magnesium / kg) or 1-4 ampoules.
The daily dose should be divided into 2-3 doses, taken with meals.
The tablets should be taken with a glass of water.
A solution from ampoules is dissolved in? glasses of water.
Treatment should be discontinued immediately after the normalization of the concentration of magnesium in the blood.
Attention
Self-breaking ampoules with Magne B 6 ® do not require a file. To open the ampoule, take it by the tip, having previously covered it with a piece of cloth, and break it off with a sharp movement, first from one pointed end, and then from the other, after directing the first open end of the ampoule at an angle into a glass of water, so that the second the tip of the ampoule was not over the glass. After breaking off the second tip of the ampoule, its contents will freely pour into the glass.
Side effect
Immune system disorders
Rarely (< 0,01%): аллергические реакции, включая кожные реакции.
Gastrointestinal disorders
Unknown frequency (according to the available data, it is not possible to estimate the frequency of occurrence): diarrhea, abdominal pain, nausea, vomiting, flatulence.
Overdose
Symptoms
With normal kidney function, an overdose of magnesium when taken orally usually does not lead to toxic reactions. However, in the case of renal failure, magnesium poisoning may develop.
Overdose symptoms, the severity of which depends on the concentration of magnesium in the blood: lowering blood pressure; nausea, vomiting; oppression of the central nervous system, decreased reflexes; changes in the electrocardiogram; respiratory depression, coma, cardiac arrest and respiratory paralysis; anuric syndrome.
Treatment
Rehydration, forced diuresis. Renal failure requires hemodialysis or peritoneal dialysis.
Interaction with other medicinal products
Contraindicated combinations
Combinations to be taken into account
special instructions
Information for patients with diabetes mellitus: coated tablets contain sucrose as an excipient.In the case of severe magnesium deficiency or malabsorption syndrome, treatment begins with intravenous administration of magnesium preparations.
In the event of a concomitant calcium deficiency, it is recommended that the magnesium deficiency be corrected before starting calcium supplements or calcium supplements.
With frequent use of laxatives, alcohol, strenuous physical and mental stress, the need for magnesium increases, which can lead to the development of magnesium deficiency in the body.
The ampoules contain sulfite, which can cause or intensify the manifestations of allergic-type reactions, including anaphylactic reactions, especially in patients at risk.
When pyridoxine is used in high doses (more than 200 mg per day) for a long time (over several months or in some cases, years), sensory axonal neuropathy may develop, which is accompanied by symptoms such as numbness, impaired proprioceptive sensitivity, and distal tremor limbs and gradually developing sensory ataxia (impaired coordination of movements). These abnormalities are usually reversible and resolve when vitamin B 6 is stopped.
The tablet formulation is intended only for adults and children over 6 years of age. For children younger age (over 1 year), the drug is recommended in the form of an oral solution.Impact on the ability to drive vehicles and engage in other potentially hazardous activities
Does not affect. There are no specific recommendations.
Release form
Film-coated tablets10 tablets in a PVC / aluminum foil blister. 5 blisters, together with instructions for use, are placed in a cardboard box.
Oral solution
10 ml of the drug in dark glass ampoules (hydrolytic class III EF), sealed on both sides, with a break line and two marking rings on each side. 10 ampoules in a cardboard packing insert together with instructions for use are placed in a cardboard box.
Shelf life
Film-coated tablets: 2 years.Oral solution: 3 years.
The drug should not be used after the expiration date.
Storage conditions
Film-coated tablets: in a dry, dark place at a temperature not exceeding 25 ° C.Oral solution: in a dark place at a temperature not exceeding 25? С.
Keep out of the reach of children.
Vacation conditions
Available without a prescription.Manufacturer
Film-coated tabletsSanofi Winthrop Industry. 82, Avenue Raspail, 94250 Gentilly - France.
Oral solution Sanofi Winthrop Industry. 82, Avenue Raspail, 94250 Gentilly, France. Cooperation Pharmaceutical Francaise. Place Lucien Over 77020 Melan, France. Consumer claims should be sent to:
125009, Moscow, st. Tverskaya, 22.
for the last 2 days I have a lot of questions about magnesium and our Magnelis well, let's compare So, Magnelis B6 forte (here it is the forte that is important, because in Magnelis, the form of magnesium is somehow indistinct and it is not worth buying it, that is, only forte, if you are thinking, 1 tablet of Magne-B6 contains: magnesium lactate dihydrate 470 mg (corresponds to 48 mg of magnesium - this is very little !!), pyridoxine hydrochloride 5 mg) Composition of Magnelis Forte: magnesium citrate - 100 mg B6 - 10 mg, and so .. ...
Magnesium and Magnelis, compare?
i have the last 2 days well, a lot of questions about magnesium and our Magnelis well, let's compare for the impatient, at the end the comparison is highlighted in bold and what to buy in the end) A small introduction: Magnesium is not for nothing considered the main energetic of cells - it participates in electrolyte, energy and plastic exchange, and also has to do with almost 300 biochemical reactions. For example, magnesium is a major contributor to muscle contraction and neuromuscular transmission. That is why a chronic deficiency of this element often leads to a feeling of weakness, lethargy, sudden ...
Magnesium preparation
Active ingredients
Release form, composition and packaging
◊ Film-coated tablets white, oval, biconvex, with a smooth shiny surface.
Excipients: sucrose - 115.6 mg, heavy kaolin - 40 mg, acacia gum - 20 mg, carboxypolymethylene 934 - 10 mg, talc (magnesium hydrosilicate) - 42.7 mg, magnesium stearate - 6.7 mg.
Shell composition: acacia gum - 3.615 mg, sucrose - 214.969 mg, titanium dioxide - 1.416 mg, talc (magnesium hydrosilicate) - traces, carnauba wax (powder) - traces.
20 pcs. - blisters (3) - cardboard packs.
20 pcs. - blisters (5) - cardboard packs.
pharmachologic effect
Magnesium is a vital element that is found in all tissues of the body and is necessary for the normal functioning of cells, participates in most metabolic reactions. In particular, it is involved in the regulation of the transmission of nerve impulses and in muscle contraction.
The body gets magnesium from food. A lack of magnesium in the body can be observed in violation of the diet (diet), with an increase in the need for magnesium or with an imbalance in the intake, metabolism and excretion of magnesium (for example, with increased physical and mental stress, stress, during pregnancy, with the use of diuretics).
Overdose
With normal kidney function, an overdose of magnesium when taken orally usually does not lead to toxic reactions. However, in the case of renal failure, magnesium may develop. The severity of symptoms depends on the concentration of magnesium in the blood.
Symptoms: decrease in blood pressure, nausea, vomiting, depression of the central nervous system, decreased reflexes, changes in the ECG, respiratory depression, coma, cardiac arrest and respiratory paralysis, anuric syndrome.
Treatment: rehydration, forced diuresis. Renal failure requires hemodialysis or peritoneal dialysis.
Drug interactions
Contraindicated combinations
FROM levodopa: the activity of levodopa is inhibited by pyridoxine (if taking this drug is not combined with taking inhibitors of peripheral decarboxylase of aromatic L-amino acids). Any amount of pyridoxine should be avoided unless levodopa is taken in combination with aromatic L-amino acid peripheral decarboxylase inhibitors.
The simultaneous use of drugs containing phosphates or calcium salts can impair the absorption of magnesium in the intestine.
Combinations to be taken into account
When prescribing antibiotics of the group inside, an interval of at least 3 hours must be observed between the ingestion of tetracycline and Magne B6, because magnesium preparations reduce the absorption of tetracyclines.
special instructions
In the case of severe magnesium deficiency or malabsorption syndrome, treatment begins with intravenous administration of magnesium preparations.
With frequent use of laxatives, alcohol, strenuous physical and mental stress, the need for magnesium increases, which can lead to the development of magnesium deficiency in the body.
When pyridoxine is used in high doses (more than 200 mg / day) for a long time (over several months or in some cases, years), sensory axonal neuropathy may develop, which is accompanied by symptoms such as numbness, impaired proprioceptive sensitivity, and distal tremor limbs and gradually developing sensory ataxia (impaired coordination of movements). These disorders are usually reversible and resolve when vitamin B6 is stopped.
Information for diabetics: film-coated tablets contain sucrose as an excipient.
Use in pediatrics
The tablet formulation is intended only for adults and children over 6 years of age. For young children (over 1 year old), it is recommended to use the drug in the form of an oral solution.
Influence on the ability to drive vehicles and mechanisms
Pregnancy and lactation
Pregnancy
Clinical experience with the drug in a sufficient number of pregnant women did not reveal any adverse effect on the occurrence of fetal malformations or fetotoxic effects.
Magne B6 can be used during pregnancy only if necessary and on the recommendation of a doctor.
Storage conditions and periods
The drug should be stored out of the reach of children at a temperature not exceeding 30 ° C. Shelf life is 2 years.