The more serious and dangerous a disease is to human health, the more expensive are modern highly effective drugs that must be used by a sick person with proper treatment of the corresponding serious illness. This is well known to all and does not require any proof.
So, a generic drug (derived from the English generic drug), or copy, is an inexpensive analogue of the original drug, which comes for sale in the pharmacy chain under a special international non-proprietary name or under an officially patented trademark that differs from the original (brand) name of this medicinal product... So, everyone is well aware of the original branded drug called "Famotidine" - this is the so-called blocker of H-2-histamine receptors, which gastroenterologists prescribe to their patients to reduce the secretion of gastric glands in the complex treatment of gastric ulcer and / or duodenal ulcer. A much less expensive copy of this drug (generic) compared to the original is produced and supplied to the pharmacy chain under the trade name "Kvamatel".
Generic drugs from India and Egypt for the treatment of hepatitis C
When a patient suffering from, for example, such an insidious and dangerous disease as chronic hepatitis C decides to start treatment, he always has a choice about buying one or another drug. You can come to a pharmacy and quite freely buy modern innovative drugs officially registered and approved for use in the Russian Federation for the interferon-free treatment of hepatitis C, for example, Vikeira Pak or Ducklinza and Sunvepra. These drugs, of course, are very expensive, but they are made in strict accordance with the original production technology at pharmaceutical plants and factories.
Generics are dangerous
for health - two deaths have already been registered in Russia!
At the same time, on the Internet, one can find significantly cheaper copies of these drugs, which are not registered and not approved for use in Russia, which are produced in India, Egypt, China, Hong Kong and even Bangladesh and are called generics (Fig. 1).
Figure: 1. How much is a generic drug
It should be noted that numerous copies of antiviral drugs, generics of sofosbuvir and daclatasvir from Egypt, India, China or Hong Kong, which have not passed official registration and have not received permission for use in the Russian Federation, are purchased by many patients at their own risk and start without agreement with a doctor to take uncontrollably as part of various interferon-free regimens for the treatment of hepatitis C, including for the treatment of HCV-associated liver cirrhosis, only at first glance seem completely harmless and safe pills. In fact, generics unregistered in Russia can pose a real threat to the health of the person taking them (Fig. 2).
Figure: 2. Generics can be hazardous to health
Currently, copies of such well-known and highly effective drugs as sofosbuvir, daclatasvir and asunaprevir, if desired, can be found and fairly freely purchased in St. Petersburg not only on the Internet, but even in some non-state pharmacies, and without any prescription. Serious harm to the patient's health, which, unfortunately, can be caused by the uncontrolled intake of inexpensive Egyptian or Indian generics, can subsequently require significant financial costs to treat possible complications. And the question of harm to health in this case is not at all in relation to a variety of "high-quality" clandestine counterfeits of original drugs, since this is punishable by law, but concerns precisely those generics that have not yet passed the appropriate registration procedure in our country and officially not approved for use in clinical practice in humans.
Also, in no case should we forget that the true clinical antiviral drugs for the treatment of HCV infection have not yet been finally established. This issue remains the subject of wide discussion and continues to cause heated debate among doctors and patients in all countries of the world, including Russia. To date, in Russia, there are already known cases of the appearance of hepatitis C virus strains resistant to subsequent antiviral treatment in those patients who independently (and sometimes on the recommendation of doctors!) Took unapproved generics of sofosbuvir and daclatasvir.
Generics are copies of original drugs in St. Petersburg - generics are especially dangerous for cirrhosis
Modern and inexpensive generics in St. Petersburg are complete and exact copies of original drugs for which patent protection has expired. In essence, such copies can be called absolute analogues of original medicines, since generics completely coincide with the original in chemical composition and are produced in exactly the same dosage form. So, if the original drug is released, for example, in the form of an aqueous or oil solution for oral administration, then the generic is in the same form, if the original is soluble tablets for oral administration, then the generic will also be sold in the form of tablets, while the amount the active substance in the generic tablets will fully correspond to the chemical composition of the tablets of the original drug. It would seem that everything is fine and everything suits everyone. But in addition to justified doubts about the actual clinical efficacy of non-original drugs, recently more and more information has begun to appear that generics that have not passed the official registration procedure and are not approved for use in Russia carry a certain danger to the health of the person taking them.
To date, two deaths have already been registered in Russia, directly related to the intake of unauthorized generics. Several patients, most of whom were diagnosed with cirrhosis of the liver with hepatitis C and who began to take unregistered copies of antiviral drugs, soon after starting taking a generic drug that did not pass the necessary chemical and toxicological examination, required emergency hospitalization in the intensive care unit due to with acutely developed or aggravated hepatic insufficiency and threatening disturbances in heart rhythm and conduction. All this was accompanied by the corresponding subsequent costly and long-term treatment in the hospital.
Everyone is well aware that in St. Petersburg generics can be found and bought without much difficulty, since almost any non-state pharmacy always has copies of many original medicines in stock. But is it worth buying them if there is even the slightest choice? Everyone should answer this question independently.
Results of treatment with generics of sofosbuvir and daclatasvir - the true effectiveness of various generics, reviews and questions from patients
Recently, more and more patients began to apply to the EXCLUSIVE clinic, who ask essentially two identical questions: “What should I do next and how to be treated if generics did not help me and the hepatitis C virus, some time after taking generics, is again determined in blood? " and “What should I do if hepatitis C virus is still detected in my blood while taking generics?”
Figure: 10. Results of biochemical examination 2 months after the end of taking generics
Figure: 11. Results of biochemical examination 3 months after the end of taking generics
Figure: 12. Results of biochemical examination 4 months after the end of taking generics
Sofosbuvir generic from India, Egypt, China and Hong Kong
Let us consider as an example the well-known Indian, Egyptian and Chinese generics of the drug sofosbuvir (see Fig. 3), which are produced at pharmaceutical plants in India, Egypt, China and Hong Kong, respectively. As you know, the original inhibitor of the NS5B viral polymerase, the drug sofosbuvir, is recommended for use in modern interferon-free regimens for the treatment of chronic hepatitis C. within 12 or 24 weeks. Currently, at least 10 different variants of inexpensive Indian, Egyptian and Chinese generics of sofosbuvir are known, and each manufacturer assures that its products are the most effective and high quality.
Figure: 3. This is how the packages of various generics of Sofosbuvir look like (GRATEZIANO, MPIViropack)
Before getting on sale in the pharmacy chain, each non-original drug generic sofosbuvir must undergo a long and thorough expert examination, as well as many special toxicological and pharmacological studies and examinations. It should also be borne in mind that the planning and execution of such clinical trials of the efficacy, safety and possible drug interactions of generics are very expensive for the companies that develop the original drugs. It is precisely the fact that the manufacturer of generics does not have the corresponding considerable costs for scientific development, conducting clinical trials, evaluating the effectiveness and safety and official license payments to the state treasury due to the low cost of copies of original drugs.
Figure: 4. This is exactly how plastic jars of generic pills of daclatasvir (top row, left) and sofosbuvir (top row, right) from Hong Kong look like - can you find the "main" difference?
Inexpensive Indian and Chinese Generic Daklatasvira
Indian, Egyptian and Chinese generics of Ducklinza, as well as generics of the drug sofosbuvir, have not yet passed the required registration procedure in the Russian Federation and, accordingly, are not allowed for use in clinical practice for the treatment of patients suffering from chronic hepatitis C. Despite this, numerous copies of the drug daclatasvir produced at pharmaceutical plants in India , Egypt, China and Hong Kong (Fig. 3) can, unfortunately, be easily found and bought in St. Petersburg. Some patients, without prior consultation with a hepatologist, begin to self-medicate at their own risk, not knowing that additional chemicals contained in non-original preparations can have a detrimental effect on cells and tissues not only of the liver, but also of other internal organs ...
A pharmaceutical copy product that has not passed official registration, examination and verification in Russia, which goes for sale in non-state pharmacy chains, can cause serious harm to health. The risks of taking generics are that even under the condition of passing the necessary and strictly defined toxicological and pharmaceutical studies, no one can guarantee one hundred percent similarity between non-original tablets and the original in terms of their chemical composition... It so happens that some of the important physicochemical and pharmacological properties of a generic drug are simply impossible to determine. It is for this reason that the widely advertised generic daclatasvir may turn out to be completely ineffective and during its administration the patient will not only not be cured, but also waste time. Therefore, before going to the pharmacy for a copy of daclatasvir, think about how it might end.
Which is treatable in most cases. Many, having heard the diagnosis of hepatitis C, do not know how to deal with it. Patients immediately fall into panic and depression, which is absolutely not worth doing. Cure the given viral disease can. How?
There are many ways to treat acute and chronic infectious disease... Everyone chooses the method of “healing” for himself. Firstly, the choice depends on the patient's financial abilities, and secondly, on the practice of the attending physician. Often, as sad as it may sound, many doctors try to test new drugs for hepatitis C on patients, which leads to disastrous results, for example, to miss the stage of the virus and develop it into a more acute form... Or to the emergence of new "sores", which were not identified during a comprehensive examination of the patient's body at the initial stage.
It is possible to completely cure hepatitis C in a patient, but for this it is important to timely identify the first symptoms of the disease and immediately consult a doctor.
As medical practice shows, many patients do not wait for their turn, according to Art. 41 of the Constitution of the Russian Federation and the Law "On Compulsory Medical Insurance" (free medical care under the compulsory medical insurance policy, valid throughout the territory of the Russian Federation) and resort to a paid method of treatment. At the moment, in order to recover from an infectious disease, you need to pay to the state treasury or a private clinic (if you still chose the service “medical care for money”) - from 40,000 rubles per month. This amount includes the purchase price of the necessary antiviral (most often foreign expensive - imported) drugs and a comprehensive examination. The duration of the course of treatment depends on the degree and type of hepatitis C in the patient. There are a great many "miracle cures" for this infectious disease, but whether they help is a serious question. In the modern world, many domestic analogues of foreign tablets and injections have appeared on the pharmaceutical market. And at a price they are cheaper than imported ones and do not differ in any way in the way of use and effectiveness.
Not so long ago, Indian drugs for the treatment of viral hepatitis C have proven themselves all over the world - this is a new and inexpensive way to get rid of a person from ailment this year. And all why? Because India is a country where at one time more than 13 million people suffered from hepatitis C. Therefore, the government of the country and many pharmaceutical companies fought for the lives of people, creating various kinds of pills and "injections" that would really help the human body to overcome the virus. After some time, they did it. And now Indian drugs are ready to help defeat hepatitis C not only in India, but all over the world.
Common treatment regimens
In orthodox medicine there are many schemes and methods for treating hepatitis C, but most often doctors, as medical practice shows, have been resorting to interferon alpha since the 80s, but it has a lot of side effects that can lead to irreversible consequences of the patient's health condition. Also, some doctors use immunomodulators in their practice, which provide an alkaline environment in which the development of hepatitis C is impossible. Therefore, immunomodulators act as blockers of the virus, but do not fight it.
All treatment regimens are individual and should be prescribed by the attending physician after a comprehensive examination of the virus carrier.
In no case should you self-medicate and resort to traditional medicine... This disease is an infection that can develop and lead to a massive epidemic due to the negligence and prejudice of the patient.
Treatment with Sofosbuvir
Sofosbuvir is a new combination drug for the treatment of hepatitis C that copies its RNA, thereby preventing the spread of the virus throughout the body. It is not a monopreparation. Unlike its foreign counterparts, this drug acts exclusively on hepatitis C. It is recommended to use it in combination with other antiviral pills, for example, with "Interferon" or "Ribavirin". In the United States, Sofosbuvir is the leading drug in the treatment of hepatitis C. Recommended use:
* sof-Sofosbuvir; rbv-Ribavirin: led-Ledipasvir; dac-Daclatasvir
Daclatasvir and Ledipasvir
Each of these drugs in combination with Sofosbuvir has a shocking effect. The cure rate is 100% even with. Ledipasvir is most commonly used to treat genotype 3. But it is worth noting that these drugs for the treatment of hepatitis C are contraindicated in pregnant women. And also with special attention it is worth using them for persons over 60 years old.
Efficiency
The effectiveness of the use of these medicines, according to medical practice, is 97%. 3% falls only for those cases when, for some reason, the created individual treatment regimen could not be applied to a specific person, for example, because of his body characteristics, an allergic reaction to some components of the drug.
Side effects
No side effects were observed. But nausea, decreased appetite, general malaise, vomiting and headache are possible. To prevent the drug from “failing”, you should follow all the instructions of the doctor, stop smoking and alcoholic beverages, follow a strict diet.
Manufacturers
The manufacturer of this complex generic is India. SOVALDI (Sofosbuvir) is considered the first among its analogues, but very expensive - the price of one tablet in the United States today is 66,000 rubles. But on the website www.sofosbuvir-express.com 400 mg (28 tablets) NATCO - made in India (Sofosbuvir) can be bought for 11,900 rubles.
Generic 2 in 1 “Ledipasvir” + “Sofosbuvir” is a generic analogue drug created to replace the original patented drug. Its price varies from 30,000 to 40,000 rubles. But on the site www.sofosbuvir-express.com it can be purchased at a low and competitive price - for 19,900 rubles.
Interferon therapy
Means - therapy based on interferon alpha is able to cure not only hepatitis C, but also hepatitis D. This solution must be stored in the refrigerator at a temperature of 2 to 8 ° C, avoid direct sunlight and exclude the availability of children to the drug.
Efficiency
The International Congress on the disease of a type of hepatitis in Spain accepted this therapy as the most effective of all its analogues in the world, but the desired result is achieved in 40-60% of cases.
Side effects
Taking the drug is accompanied by the following side effects:
- An increase in the total number of leukocytes in the blood, which can lead to kidney failure.
- Influenza-like syndrome: Most patients begin after starting interferon treatment. Manifested by fever, aching joints and muscles, chills.
- Loss of appetite, bitterness in the mouth, nausea.
- Fatigue may occur throughout the treatment.
- Rash and itchy skin.
- Depression.
- Hair loss, dry skin, weight loss.
"Ribavirin" is a combined antiviral agent capable of defeating hepatitis C, which is not used as a monopreparation. When ingested, it is absorbed through the digestive tract. Most often, it is prescribed by doctors together with pegylated interferons.
Efficiency
Such a combined agent as "Ribavirin" in its complex leads to a persistent virological response to the disease. Despite the high degree of effectiveness, this medicine has a lot of side effects, with which the quality of life of the healthy organs of a sick person decreases.
Side effects
Side effects of this drug include headache, aggressive behavior, nervous irritability, fainting, tremors, hearing loss, damage to the lacrimal gland, skin rash, violation of hair structure, bronchitis, rhinitis, tinnitus.
Comparative analysis of treatment methods
An analysis of standard regimens and the cost of treating hepatitis C in Russia shows that for a full 6-month course, Sofosbuvir is considered an effective treatment method, for which an average of 167,400 rubles will have to be paid. In second place is Ribavirin - 151,200 rubles. In order not to spend so much money on drugs against hepatitis C, buy them from us. All products from India are of high efficiency and quality.
On the site www.sofosbuvir-express.com you will find preparations of Indian origin, which are recognized as the most effective and inexpensive analogues of foreign drugs in the fight against hepatitis C. Do not pay big money for something that can be purchased cheaper. Indian medicines meet all international standards, giving 100% results. Hurry up to live a long and healthy life!
Hepatitis C is a viral disease that is asymptomatic for a long time. The virus is transmitted through blood, enters the human body through wounds on the skin and mucous membranes. The main "blow" is on the liver.
By differences in the structure of RNA, 6 genotypes of the virus are distinguished, each of which is divided into several more quasi-species. Each of the varieties of the virus is capable of mutating, developing drug resistance. This phenomenon explains the fact that there is still no effective vaccine for hepatitis C.
The incubation period of the disease is long (up to 50 days), then patients may face the following manifestations of the disease:
- decreased or lack of appetite;
- weakness;
- abdominal pain;
- hyperthermia;
- the appearance of a rash resembling an allergic.
The acute stage of hepatitis lasts no longer than a week, after which the disease becomes chronic. Symptoms of this period: yellowness of the mucous membranes, skin, urine becomes dark, feces become discolored.
Liver samples and blood chemistry help to confirm the diagnosis.
For many years, the treatment of hepatitis C was based on a combination of two drugs - Ribavirin ( antiviral agent) and Interferon Alpha (immunomodulator). Nevertheless, this combination, along with therapeutic effect caused many side effects. There was a need to find an effective and at the same time safe means against hepatitis C.
Effective medicine
Modern drug therapy of the disease involves the use of the Indian drug Sofosbuvir. The medicine is used to treat the chronic form of the disease, it is indicated for patients over 18 years of age.
This Indian remedy is produced in tablets (1 package - 28 tablets, each of which contains 400 mg of the active substance).
The mechanism of action of the drug:
- has a depressing effect on NS5B RNA polymerase;
- blocks the process of replication of the virus - the causative agent of hepatitis C.
How it works: Once in the blood, the hepatitis C virus quickly enters the liver. Here hepatocytes are "rebuilt" to synthesize proteins needed by the virus. The task of Sofosbuvir is to prevent the multiplication of the virus by stopping the synthesis of "foreign" protein by liver cells.
The active ingredients of the Indian medicine:
- sofosbuvir;
- ledipasvir.
Three-month treatment with the drug costs patients $ 1,500.
The uniqueness of Sofosbuvir is that this drug does not interact with the cells of the human body, does not affect the immune system.
Benefits of tablets according to clinician reviews:
- convenient form of release, clear dosage;
- affordable price;
- demonstrates effectiveness in patients with hepatitis and liver cirrhosis;
- the drug can be used by patients awaiting liver transplantation as a means to prevent re-infection with hepatitis.
Advantages of the drug according to patients:
- The effectiveness of the treatment is achieved within 3 months. Traditional therapy with Interferon and Ribavirin is longer.
- The desired effect is achieved in 90% of clinical cases.
- The Indian drug, unlike its analogues, practically does not have a harmful effect on the human body.
- The medicine can be used to treat patients with hepatitis C and liver cirrhosis.
Indications for use: Sofosbuvir is prescribed to patients with a chronic form of the disease, treatment is carried out even when the patient is diagnosed with HIV infection.
The use of the drug is always associated with the intake of other drugs (combined approach to the treatment of hepatitis C). The dosage is selected individually for each patient, taking into account body weight. Monotherapy with Sofosbuvir is not recommended.
Variants of drug combinations (due to the genotype of the virus):
- Gp 3–6 - Sofosbuvir + Interferon Alfa + Ribavirin. The course of treatment for hepatitis is designed for 90 days or more.
- Г-п 1, 4-6 - the same combination or without Interferon (if the patient is contraindicated to take Ribavirin). The therapy is carried out within six months.
- Gp 2 - Ribavirin + Sofosbuvir. The course of treatment is 3 months.
The duration of therapy depends on the duration of the infection and the stage of hepatitis. Treatment usually takes about 2 months.
Important: Indian pills against hepatitis C are taken exclusively with food (drink without chewing). If vomiting occurs within 2 hours after taking the drug, the drug is taken again.
The use of Indian Sofosbuvir as part of a three-component system provides a 95% positive result.
Other schemes for taking Sofosbuvir:
- for liver cirrhosis - Sofosbuvir + Ribavirin (6 months) or in combination with Harvoni (12 weeks);
- for HIV infection - Ribavirin + Peginterferon + Sofosbuvir; Sofosbuvir + Daklatasvir (course of treatment - 3 months);
- in case of a negative response to previous therapy - Harvoni (12 weeks); Ribavirin + Sofosbuvir (6 months).
Precautionary measures
Sofosbuvir is contraindicated in patients with individual intolerance to certain components of this Indian medicine. It is not recommended to take pills to pregnant and lactating women, as well as to persons under 18 years of age.
Caution should be exercised when using the drug for women of reproductive age (the effect of Sofosbuvir on their body has not been clinically tested).
Elderly patients, as well as people suffering from liver failure, should use the Indian drug for hepatitis exclusively under the supervision of a specialist.
Taking an Indian drug in combination with traditional hepatitis medicines has a number of side effects. Patient reviews indicate that such a combination as Sofosbuvir + Ribavirin causes the following manifestations:
- increased irritability, weakness, rapid fatigue;
- the level of hemoglobin in the blood decreases, bilirubin - increases;
- sleep disturbances;
- vomiting and nausea occur from time to time.
When combining the reception of Sofosbuvir with Interferon and Ribavirin, the patient may experience the following symptoms:
- pain in joints, muscles;
- shortness of breath;
- cough;
- sleep problems;
- anemia;
- neutropenia;
- the level of leukocytes and platelets in the blood falls;
- hyperthermia, chills;
- nervous disorders;
- rashes appear on the skin;
- dyspepsia, impaired digestion;
- there are problems with vision and concentration;
- dehydration, dry skin;
- convulsions, migraines, sudden weight loss;
- asthenia, back pain and chest pain.
Taking medication is associated with the risk of allergic reactions (rhinitis, itching of the skin, hyperemia, swelling). In this case, the doctor must adjust the therapeutic regimen or stop taking the pills.
To minimize negative manifestations, it is recommended to limit the use of alcoholic beverages, fatty, fried foods during treatment (all this is an additional load on the liver). The diet should be balanced, patients are shown moderate physical activity in the fresh air and the absence of emotional distress.
Drug analogues:
- Ledipasvir.
- Algeron.
- Cycloferon.
- Pegintron.
- Alfaron.
Drug interactions: The use of an Indian drug in combination with other antiviral agents is permissible only if the benefits of such treatment outweigh the potential risk. Do not use Sofosbuvir in combination with Boceprevir or Telaprivir.
Treatment of hepatitis C with the Indian drug Sofosbuvir should be carried out exclusively under the supervision of a specialist.
Over a long period, while creating a virus carrier - a patient. If timely medical intervention is not performed, then there is a risk of cirrhosis or cancer of a vital organ.
If you find out about the presence of a virus in your body, you should immediately start treatment, because every minute is precious. The virus imperceptibly, but surely eats away your liver and soon the point of no return may come. When your liver is affected by cirrhosis, it will be almost impossible to restore it to its previous state. Therefore, if you have no contraindications to treatment, read this article and do everything necessary to start treatment. Fortunately, today there are already reliable methods of HCV treatment in the world.
Also, in order to protect your loved ones and prevent the transmission of the virus, check out our article:.
For a very long time, the only way to treat hepatitis C was interferon therapy. Within a year, patients had to take this medicine, but only half of the cases were positive. In this case, the side effects often nullified the entire treatment.
Medicine has stepped forward and today patients can use a new medicine for hepatitis C. Modern treatment hepatitis C with generic drugs such as Sofosbuvir, Daklatasvir and Ledipasvir leads to the expected result in 98% of cases. Unlike interferon, generics have a positive effect on the patient's body and have practically no side effects.
Operating principle
These antiviral drugs act directly on the RNA of the hepatitis C virus, which makes it possible to achieve high efficiency in the treatment of the disease. After the virus stops multiplying and growing, it weakens and is completely eliminated from the body.
It should be noted that the price of the original drug ranges from $ 50,000 and more. But now, thanks to the production of India, there is an alternative product on the drug market - a generic for hepatitis C, which is more affordable. The cost of such a course of treatment will cost approximately 40-70 thousand rubles.
Indian manufacturers produce a colossal number of unique antiviral therapy analogues. Sometimes it is difficult to make your choice which of the generics will be able to give the expected result.
What are generics and how do they differ from the original drug Sovaldi, Harvoni, Daclinza?
Generic is an Indian drug for hepatitis C, a unique pharmaceutical substance, the intensive element of which is published in the absence of a patent. According to the formula, such drug copies differ only in additional elements (dyes and fillers). Information, impacts and acceptable secondary outcomes are equal, but their prices are different.
The release of generics from India, such as “Sofosbuvir”, was first reported a year after the release of a unique substance, that is, the original.
In India, they emerged in March 2014. The original licensed drug was Hepcvir, manufactured by Cipla Ltd. The price of such a drug was $ 2,500 for 6 packs, each containing 15 tablets. After a while, such a drug began to be used in treatment, and to control the reaction of the sick person's body to the components of the drug.
A generic, like any other drug, has its own specific characteristics and requirements:
- the permissible ratio of the main pharmaceutical parts, according to the qualitative and numerical criteria.
- generally accepted measurements.
- the production of the drug should be carried out strictly under the supervision of specialists.
- observance of the color equivalent, according to the main characteristics of absorption.
Another manufacturer is Natco Pharma Ltd. This company produces a drug with the trader's name "Hepcinat". Indian generic can be purchased for $ 945 for a full 12 weeks course. The current price for today can be found by clicking on the picture below.
Certain unique antiviral drugs, "Sovaldi", "Ducklinza", "Sunvepra", "Sovriad", "Vieira Ice", Harvoni "," Zepatir "," Epkluza "and others were previously released only in Europe and the USA. Inexpensive generic versions of certain drugs are available in India.
A generic drug that meets all the requirements is no different from its original, with the exception of a tangible difference in price for the drug.
Why Choose Indian Generics?
When choosing an analogue of a drug to fight liver disease, it should be remembered that this drug has passed many clinical tests and is recognized in Europe as one of the better means to combat liver disease.
In order to start treatment with an Indian generic drug, you must undergo a full course of examination, and the degree of cirrhosis. All genotypes are treated with a combination of Sofosbuvir and Daklatasvir, but for the first genotype there is a treatment regimen with a combination of Ledipasvir and Sofosbuvir.
The standard course of treatment is 3 months or 12 weeks, but the first results can be obtained by passing the test after a week of taking the drugs. The positive dynamics of reducing the amount of the virus in the patient's blood is observed throughout the entire course of taking the drugs, until the virus disappears completely.
An important condition for Indian generics from hepatitis C is a competent combination of funds.
For example, the generic drug Daklatasvir is used in conjunction with Sofosbuvir. The first component inhibits the reproduction of viral protein throughout the body; , restores dead liver areas and acts as a protector of healthy cells, preventing them from being affected.
After taking such a drug, the patient has a significant improvement in the general well-being of the body, since the generic blocks the virus. Usually already at the 4th week it shows the absence of the virus.
No relapses of the disease were observed during the course of the course in accordance with all the recommendations of the attending physician.
General requirements for the production of generics
Because a generic is a clone of the original drug, a certain technology must be followed in its manufacture:
- equivalence to the original in terms of the form of effectiveness and reaction rate of the components,
- the ratio of the component of the drug - the maximum permissible indicators,
- compliance with the stated requirements,
- availability.
Do not be afraid that Indian generics are cheap fakes. This is not true. Indian generics are 100% analogs of original drugs, which are more accessible to a person in need. In order to enable almost all inhabitants of the planet to recover from such a disease as hepatitis or to prolong their life for a while, such a drug was created in India. 
Varieties of Indian drugs for Hepatitis C
In the modern world, there are analogues of drugs that help to cope with liver disease, such as:
- "Sofosbuvir Hepcinat",
- "Sofosbuvir Hetero",
- "Sofosbuvir SoviHep",
- "Daklatasvir Natdac",
- "Daklatasvir Hetero",
- "Daklatasvir Zydus"
- "Ledipasvir Lp"
- "Ledipasvir Ledifos",
- “Ledipasvir LediHep” and so on.
Modern generics with appropriate treatment can achieve 98% of the result. They are not dangerous and can be used even after interferon therapy.
Manufacturer list
Over time, each Indian drug has its own manufacturers, such as:
- "Natco Pharma"
- "Hetero labs"
- "Zydus Cadila Healthcare Ltd"
- "Mylan"
- "Dr Reddy's Laboratories"
- "Biocon ltd"
- and some others.
All of the listed manufacturers of Indian generics have hundreds of thousands of cured people behind their backs. These drugs were used primarily to stop the hepatitis C epidemic in India. Now they are available for our compatriots. To get advice on ordering and delivery to your region, call the free hotline 8-800-200-59-21 from 8 to 20 Moscow time.
What is the difference?
These drugs, or rather their various manufacturers, retain the entire composition of their product, so the only difference between them is the price, but not the quality. Therefore, when choosing a particular drug, you should not worry about its effectiveness. The difference in price is caused by the different marketing campaign of the manufacturers. Factories that invest more money in advertising and promote their products more actively raise the price of their drugs.
Treatment for Hepatitis With Indian Generics
Medicines for hepatitis C from India stop the multiplication of the virus in the body and contribute to its complete elimination. Usually on full recovery 12 weeks of medication is enough. Before taking the drug, it is necessary to consult your attending physician, as it depends on the condition of the body. A longer course of treatment or ribavirin may be required. As a rule, using the medicine daily with food, a positive effect occurs within 3 months. And the first results can be obtained already having passed the PCR blood test a week after taking it. However, the recovery process may take longer and may take up to six months, depending on the characteristics of the course of the disease, the presence of cirrhosis and coinfections.
Modern treatment regimen and how to take
In order to prescribe a certain course of treatment, the doctor must exclude possible contraindications to the use of generics:
- age to majority,
- chronic cirrhosis of the last stage,
- pregnancy and lactation,
- liver transplant,
- an allergic reaction to the components of the drug.
Despite the fact that each generic package contains instructions for use, it is best to follow the doctor's recommendations.
During treatment, do not expect daily improvement. Let us remind you that generics are a complex treatment that gives results not immediately, but within 3 months. The main thing is to take the drug strictly at the time indicated by the doctor and in a certain dosage, in no case interrupt the course of treatment and do not consume alcohol during therapy.
Sofosbuvir
An effective drug created for the treatment of hepatitis of any group, testing of which showed almost 100% of the result. The component of such a generic drug is aimed at blocking NS5B enzymes, as a result of which the virus is unable to multiply by RNA. The duration of the course is on average 3 months. Side effects are noted from the digestive system and the nervous system. But most often this drug does not cause side effects.
Main brands
The main manufacturers of this drug include:
- "Hepcinat"
- "Sofovir"
- "Sovihep".
Hepatitis C tablets from India contain 400 mg of the substance (28 tablets per package).
Daclatasvir
Declatasvir is a protein inhibitor of the hepatitis microbe of any group. acts as a blocker of infected cells, does not allow them to grow further. According to the results of clinical trials, the effectiveness of this generic drug was 97.5%. Side effects include nausea, seizures, migraines and depression. The total recovery period of a vital organ from the moment of taking the drug is six months. Doctors prescribe this remedy in the last stages of hepatitis.
Main brands
- "Natdac"
- "Daklahep"
- "Dacihep"
Each tablet contains 60 mg of the substance, 28 tablets in a package.
Ledipasvir
Ledipasvir - in other words, the substance GS-5885, a modern generic drug used in the complex treatment of hepatitis of any group. The substance used in this preparation is capable of positively affecting the hepatitis microbe. The course of taking such a drug is 3 months. Combines with Sofosbuvir. The performance rate of Ledipasvir is 93%. Numerous studies have shown that the use of this generic drug does not cause practically any side effects, except for individual intolerance to the components of the drug.
Main brands
The main brands that produce this generic include:
- "Hepcinat Lp"
- "Ledifos"
- "Ledihep"
This type of generic is available in jars of 28 tablets, each tablet contains 90 mg of the substance.
How and where to buy?
Many, having read a large body of information about hepatitis different kind, as well as about the effect of Indian remedies, they do not know where to buy generics to treat their ailment. This is because modern drugs for hepatitis C are not allowed to be sold in Russia, according to the legislation of the Russian Federation and the license agreement of the company that patented the drugs with the state of India. But don't worry, we will help you solve your problem.
You should not trust amateurs with the decision of your fate, since, probably, apart from promises you will not see anything from them, while paying a large sum of money for drugs.
These drugs cannot be found in a domestic pharmacy or. If you go to India yourself to buy drugs on the spot, then you may have problems transporting them to the territory of the Russian Federation. It will also raise the cost of the medicine due to the cost and extra charge at an Indian pharmacy.
It is best to contact the official suppliers who will take care of all the problems in the delivery of the drug. In the market of companies transporting Indian Hepatitis C medicine "Sofosbuvir Express"has proven itself perfectly. You can order sofosbuvir and other drugs through sofosbuvir-express.com. This company has been successfully helping people recover from ailments for more than 2 years. You can read reviews of satisfied patients, and watch video reviews below. On their account there are more than 4,000 people who have recovered thanks to the purchased drugs. Don't put your health on the back burner. Call now and get step-by-step instructions on how to get rid of hepatitis C once and for all.
Free hotline for calls within the Russian Federation. Every day from 8 to 20 Moscow time.
One of the most common types of hepatitis that adversely affects the liver is hepatitis C. For a long time, its symptoms can be hidden, which makes the sick person a carrier of the virus. If you do not start treatment on time, there is a risk of developing liver cancer or cirrhosis.
Treatment of the virus with the latest direct-acting drugs (for example) is carried out quite successfully, but the cost of a course can be more than one hundred thousand rubles. An alternative to popular drugs was developed in India - generics against hepatitis C. Such drugs include Daklatasvir.
Features of generics
Generics are a kind of "replica" of the original drug, the active substance of which is produced without a patent. In composition, such copies differ only in auxiliary components. The indications, actions and possible side effects are the same, but the cost can be several times lower.
Direct-acting drugs, guaranteeing an absolute cure for hepatitis C, first appeared on the market in 2013. Thanks to them, the duration of treatment was reduced significantly.
Pharmacists claim that recovery occurs in 90% of patients, and the number of side effects is reduced.
New generation drugs are also used to treat those who have already had an unsuccessful attempt at therapy with ribavirin or interferon drugs.
One of the first direct-acting drugs for hepatitis C was patented Sofosbuvir. Generics of this drug from India are supplied to pharmacies in 91 countries. Two products were distributed - Hepcvir and Hepcinat.
In 2014, Harvoni appeared in Germany. A year later, Indian generics began to be produced - Hepsinat, Heptsvir-L, Mikhep Lvir, Ledifos.
All generics must meet certain requirements:
In 2015, an inhibitor for the treatment of hepatitis C, Daklatasvir, was developed. The patented drug is named Ducklinza.
In the same year, generics appeared in Bangladesh (Daklavir), China (Sodak) and India (Natdak).
Daclatasvir blocks or slows down one of the components of the hepatitis C virus - the NS5A protein, which can significantly reduce the activity and "vitality" of the virus.
In addition, the drug inhibits the spread of already existing viral particles throughout the body, protecting healthy cells from viral infection. Thanks to this, it can be used against all genotypes of the virus.
Rules and features of admission
Daklatasvir can only be prescribed by a doctor. All laboratory tests must be carried out to obtain a general clinical picture of the disease. Self-medication is not allowed: it will not bring the desired effect, irreparable damage can be caused to the body.
There is no single instruction for the treatment of hepatitis with Indian generics: the regimen is selected individually for each patient.
The doctor must not only create a schedule for control laboratory studies, but also determine the required dose and an auxiliary component that should be used with the drug.
However, there are certain rules for taking the Indian drug Daklatasvir:
As an independent medicine, Daklatasvir is not used, therefore, its appointment must be accompanied by the intake of antiviral agents.
The attending physician should select the optimal additional agent. In certain cases, sofosbuvir is additionally required for the most effective treatment, which blocks the dangerous hepatitis protein.
Treatment of hepatitis C with Indian generics will take from three months to six months. If a constant virological response does not appear during this period of time, the drug under such conditions is canceled due to insufficient effectiveness.
The treatment regimen should depend on:
There are several common treatment scenarios. They last:
During the course, it is important to pass interim tests in a timely manner, the course of treatment can be assessed only by their indicators.
Contraindications
In some cases, Indian generics cannot be used. Daclatasvir has certain contraindications, which include:
Under certain conditions, Daklatasvir is allowed to be taken even with existing cirrhosis or after surgery. Only the attending physician can make a decision, after conducting all the necessary studies.
While taking Indian generics, it is advisable to avoid conception.
Abstinence lasts about five weeks after the end of the full treatment course, the rule applies to both partners.
Advice from hepatologists
In 2012, there was a breakthrough in the treatment of hepatitis C. New direct-acting antiviral drugs have been developed, which with a 97% probability of completely eliminating the disease. From this point on, hepatitis C is officially considered a completely treatable disease in the medical community. In the Russian Federation and the CIS countries, drugs are represented by the brands sofosbuvir, daclatasvir and ledipasvir. At the moment, there are a lot of fakes on the market. Medicines of good quality can only be purchased from companies that have licenses and appropriate documentation.
Side effects often depend on which additional drug is used with Daklatasvir. The following negative consequences are possible:
About all side effects you must immediately inform your doctor. The appearance of such alarming symptoms does not mean discontinuation of the drug. If possible, the specialist will try to find another antiviral adjuvant.
Do you still think that it is impossible to defeat Hepatitis C?
Judging by the fact that you are now reading these lines, the victory in the fight against Hepatitis C is not yet on your side ...
And have you already taken toxic drugs that have a lot of side effects? It is understandable, because ignoring the disease can lead to serious consequences. Fatigue, weight loss, nausea and vomiting, yellowish or grayish skin tones, bitterness in the mouth, body and joint aches ... Are all these symptoms familiar to you firsthand?
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