Injections Artrosilene is a multiform medicinal drug from the NSAID category. Vin is characterized by selective and prolonged action. The medicines harden, which, when combined with other medicines, creates a smooth and gentle flow into the middle of the fire. Injections are prescribed for the most difficult cases, if there is significant trauma after surgery.
Lika components
Cover your skin with non-steroidal anti-inflammatory drugs. Perchocherkova action and ketoprofen lysine salt. Additional components are available in the warehouse. Among them are sodium hydroxide, citric acid and purified water.
How does Artrosilene injection manifest itself?
In stock, the main component is a colored modification of ketoprofen. Once the pH level has been adjusted, it will soon break down. For this reason there is no indication of the scolio-intestinal tract. Likuvalna action can last for twenty-four years. Medical practitioners note that such a variation of the active substance does not flow into the cartilaginous tissue of the joints.
The medical drug Artrosilene can be used threefold. Under this influx, analgesic, antipyretic and anti-inflammatory effects appear simultaneously. The storage components of the milk suppress the synthesis of prostaglandins, which reduces the effects of illness. Also, doctors keep their assigned information, behind which doctor's special In the postoperative period after transplantation of the globules, it is possible to prevent calcification of the cysts and soft tissues. Take positive influx The drug can significantly speed up the pregnancy period.
The practice of drug therapy has shown that the drug is highly effective. The effectiveness of the action can be equaled even with narcotic analgesics. In the treatment of ailments associated with swelling, the drug can reduce swelling and slightly reduce wound tightness. Therefore, the debt of the Rukhs is growing significantly.
Pharmacokinetics
When administered internally, the drug may be quickly absorbed. In the blood, the maximum concentration is reached after forty minutes. The effectiveness of the lenses can be maintained for 24 years. More than 95% of the main component can bind to plasma proteins. Ketoprofen lysine salt easily penetrates through the walls of blood vessels and can be distributed throughout the tissues and organs. These characteristics make it possible to achieve immediate access to pain relief.
Showing
Doctors for arthrosis patients recommend reading the instructions carefully. Treatment with injections is not suitable for everyone. Therefore, the medicinal drug should be insured to powerful levels. It is prescribed by doctors for serious injuries or for prevention after surgical procedures.
Presumably, the drug Artrosilene is indicated before drying and is indicated as a short-term treatment for diseases of the cystic-muscle-muscle apparatus. In this aspect, injections can be eliminated even with complex therapy. The stench looms at any time to lift the pain. They are indicated if there is a looming injury or fire in the cartilage-muscle system.
Contraindicated
Before using artrosilene in ampoules, you must carefully read the instructions. Injections may not be given to the skin, for example, to minor patients due to infection. Women should be treated with medication during pregnancy and lactation. Moreover, it is necessary to respect the patient’s condition, in which case it is not possible to accept the patient’s face.
The use of this medication is not recommended for those who have been diagnosed with vulcanis of the duodenum. Also, if there is a loss of laryngeal blood, there is chronic nitric deficiency. For patients who suffer skin diseases, it is not possible to take a course of treatment with medication
Many doctors carry out treatment with artrosilene in the hospital’s washrooms. Injections are prescribed inclusively for the results of completely restraining the patient and making an accurate diagnosis. A tall doctor will learn about the history of the disease from now on.
Such approaches can significantly prevent the development of side effects and others. bad reactions. This medication is prescribed with particular caution to people who are currently diagnosed with hepatic or chronic heart failure. When diagnosing arterial hypertension or sepsis, care must be taken.
special inserts
Before starting a course of treatment, the doctor will check the peripheral blood picture. It is important to check the normal functioning of the stove, however. Doctors are especially confident that people with illnesses can detect the presence of infection. This situation is explained by the fact that the drug is used to relieve pain.
Liki does not give much pressure to the development of infection. The result significantly improves the patient's figure. For richer patients, the injections are more painful. Medicine is in its disorganized situation, for which there are episodes of loss of information during the final manipulation. The stench is hard to bear.
You can greatly protect yourself from unwanted consequences by taking small injections in supine position. One of the most unacceptable is internal ulcer injections, and pain syndrome may occur quickly. When undergoing therapy with artrosilene, there is no interference with transport mechanisms.
It is also possible to avoid robots that require increased concentration of attention. Enable hit on skin curves ultraviolet.
Dosing of injections
Register LP for cob stage internally or internally, one hundred and sixty milligrams per dose, which makes one ampoule. In severe episodes, the dose is doubled. Doctors explain that it is unacceptable to exceed the total dose by more than 2 ampoules. Sick people over 65 are not prescribed more than 160 milligrams per day. This description applies to people who may be diagnosed with liver failure.
What is more important are injections of three dibs. Open the ampoules carefully, following the indicated line. After these processes, it is necessary to immediately freeze. Zgodom medical practitioners Please take suppositories and tablets. Injections should be taken inclusively at medical stores under the supervision of doctors.
It is possible to prolong the infusion of liquids after stagnant infusions, depending on the introduction of liquids internally by stretching the surface. The medicine is prepared with the following ingredients: sodium chloride, aqueous sodium levulose and dectoside. The procedure can be more easily tolerated by patients if the injections are administered in a supine position.
Overdose
Zastosovuyuchi artrosilen injections, it is necessary to suvoro dosage. This recommendation is supported by numerous studies of university physicians, who have shown that incorrect use of the drug affects the patient’s self-esteem. Unacceptable symptoms may appear in the scolio-intestinal tract. Signal yourself with sickness, confusion, and boredom. If the dose is overdose, the doctor will initiate symptomatic therapy. Doctors will focus on monitoring the respiratory and cardiovascular systems.
Side effects
Doctors explain to patients that, regardless of the safety of the medication, it may side activities. Based on the treatment of medical professionals and patients, negative symptoms appear in some cases. Still, it’s better to know what you can do to treat a patient with injections.
The herbal system's side effects are manifested by abdominal pain, stomatitis, and increased activity of liver enzymes. Erotic storms can also affect the flow of water. The central nervous system may have an undesirable effect on body tremor and disturbed sleep. In isolated situations, you may experience a loss of vision. When undergoing treatment with arthrosilene injections, it is possible to avoid drinking alcoholic beverages. They may develop negative reactions.
Varto beware of undesirable inheritances in case of heart failures. The manifestation of negative symptoms may result in chest. The culprit is not tachycardia or syncope. Presence of negative symptoms in the injured dicholic system, which manifests itself as rhinitis, bronchospasm and swelling. In many cases, hypertension develops.
Medical mutualism
The metabolism of ketoprofen can be significantly accelerated by inducers of microsomal oxidation in the liver. Among them are barbiturates, ethanol and rifampicin. Treatment with artrosilene replaces the use of uricosuric medications. Doctors in their orders recommend avoiding the combination of medications with antihypertensive medications or diuretics.
It is necessary to carry out treatment with injections with caution when combining them with other non-steroidal anti-inflammatory medications. The insert says that this kind of treatment can cause varicose veins or lead to intestinal bleeding.
There is also an increasing risk of damage to the robot. Caution regarding the use of medications extends to people diagnosed with diabetes. Immediate treatment with ketoprofen and insulin leads to an increase in the concentration of the remaining substance in the blood.
Before starting a course of treatment, patients with such a diagnosis may overdosing. The correct treatment tactic is consultation with a doctor if you are taking other medications at the same time. Patients are responsible for the risk of medicinal diseases with other drugs. This rule is more important, skin fragments pharmacological form May be the rules of Wikoristan. You can read about them in the instructions that come with the drug.
Analogues of Likiv
If treatment with artrosilene is required, cheaper analogues can be added. These drugs include other active substances, but their action follows the same principle. When excluding analogues, emphasis should be placed on their biological availability. Call your analogues lower.
When changing the drug, it is necessary to consult your doctor. Decisions about a possible replacement can be made only by the doctor, depending on the severity of the illness and the individual characteristics of the patient. So the drug ketonal takes place of ketoprofen lysine salt, which is a group of non-steroidal drugs.
It has antipyretic, antipyretic, analgesic effects. The active substance can inhibit the synthesis of prostaglandins and stabilize liposomal membranes. It flows into the peripheral nervous system. The connection between the two will change You'll feel the pain. LZ is indicated for patients who suffer from rheumatoid arthritis. Yogo is prescribed for diseases of the musculoskeletal system.
Injectable ketoprofen is prescribed by doctors for pathologies such as arthritis of the knees and osteoarthritis. Helps with various painful conditions such as toothache, neuralgia, radiculitis, etc. It is contraindicated for patients diagnosed with chronic illness sclero-intestinal tract, disruption of the process of laryngeal blood, vaginosis.
Before analogues to artrosilene, Flamax should be used, the main component of which is ketoprofen. It has the power to lower the temperature, increase pain, and speed up the development of ignition processes. The drug is based on similar propionic acid.
Injections are recommended for relieving pain of any nature, inflammation of the pelvic organs, renewal after surgery, oncology. Medication contraindications for narcotic and hepatic insufficiency, bronchial asthma, coronary artery bypass surgery.
Bistrumcaps is prescribed for diseases of the cysto-muscular system. Effective for pain syndrome across the spine, post-traumatic (sports injuries, clogged muscles, sprained ligaments). Characterized by trivalim a festive day. This should be used with caution for people whose activities require rapid psychomotor reactions.
Unfortunately, no one is insured against injuries. Actions of violence can be so strong that it is impossible to manage without the help of a doctor. The doctor will not only help to extinguish the ignition process, but also relieve the patient of unbearable pain. In case of serious injuries and after surgical administration, the drug “Artrosilene” is often used. Injections are prescribed in the most severe cases. In pharmacies you can find liquids, candles and tablets.
Medicine warehouse
The drug is classified as the main component of ketoprofen, lysine salt. In addition, substances such as sodium hydroxide, citric acid, and purified water are also used. The drug is supplied to pharmacies in glass ampoules packed in cardboard boxes.
I have a comprehensive treatment with “Artrosilen”. The injections help relieve fever, clear up fires, and also control the analgesic effect. The patient feels relief already on the first day of therapy. Ketoprofen lysine salt is sweetened with rosemary. Therefore, in the process of treating a patient, the scolio-intestinal tract is practically not damaged. The main component does not flow onto the subglobular cartilage. During the treatment process, the patient does not feel the wound tightness and swelling of the joints.
Pharmacokinetics
When I take the internal capsules, the drug will be absorbed quickly from the intestinal tract. Maximum bioavailability can reach 80% and is reached in 4-5 years. Indicators of bioavailability depend on the dose the patient takes. Fahivtsi do not recommend living with your skin at the same time. This corresponds to a daily decrease in the bioavailability of the main component that is present.
When administered intravenously or internally, the liquids must also be wetted quickly. The maximum plasma concentration can be reached after 40 minutes. The jubilant effect is preserved by stretching the product. More than 95% of the main component that is present binds to plasma proteins. Ketoprofen lysine salt easily penetrates through the walls of blood vessels and is distributed in tissues and organs. Zavdyaki whose pain-inducing effect is within reach.
Showing
In advance, they are vaccinated by those who have recovered from the injury, so that the instructions for stagnation are given to the drug “Artrosilene”. Injections may not be suitable for everyone. Medication can be classified as powerful and may be used in case of serious injuries or as a preventive treatment after surgical procedures.
A short-term treatment of pain syndrome is acceptable in case of illness of the carpal-muscle apparatus. In this case, the complex therapy "Artrosilen" (injections) is prescribed. The results show that the drug often reduces inflammation and relieves pain. To determine the cause of the illness, it is necessary to use special medicinal purposes university profile.
Do not take the drug Artorozilene without consulting a doctor. The injections also have their own contraindications. In addition, doctors do not recommend using a strong dose for minor injuries.
Contraindicated
Before using the drug "Artrosilene", the instructions for use are due. Not everyone can benefit from injections. Thus, this potent drug is not prescribed to minors. Likewise, women cannot cope with pregnancy during pregnancy and lactation. There is also a low number of serious contraindications associated with the health of the patient. If a person has been diagnosed with viral disease of the colon and duodenum, obstruction of the throat, diverticulitis or chronic nitric deficiency, it is better to choose another medication.
As practice shows, in most cases of seizures, the hospital itself is treated with the drug “Artrosilene”. Injections may be indicated only after the sick person has been thoroughly restrained and a diagnosis has been made. A qualified physician is initially responsible for taking into account the history of the patient’s illness in order to prevent the possible development of side effects and other negative reactions, without forgetting about other contraindications. Caution is taken for patients who suffer from diabetes, liver failure, and chronic heart failure.
special inserts
Before starting to treat goiters, check the peripheral blood picture, as well as the functional state of the liver. Varto vrahovuvat that by taking the “Artrosilen” method you can mask the appearance infectious disease. Due to the fact that the patient’s face appears to have a pain syndrome, the patient’s self-esteem significantly improves. In this case, the medication does not affect the development of infection.
As the symptoms show, the beginning of therapy is called upon to finish not acceptable"Artrosilene". The injections are painful, and the patient has a hard time enduring the procedure, even if there are guilt. Medicines show signs of loss of information during the course of manipulation. Fahivtsi recommend giving injections to a person lying down. Prote bil dosist shvidko minaet.
Dozuvannya
At the ear stage, medicinal products are prescribed internally or internally at a dose of 160 mg per dose (1 ampoule). In the worst cases doba norm may be doubled. The maximum dosage does not require overfilling two ampoules. Patients over 65 years of age should not be prescribed more than 160 mg per dose. This is the rule when people suffer from liver failure. How long does it take to take Artrosilene? Give injections three times more than three days. They further recommend switching to frozen suppositories or tablets. In'ektsії to pay for the minds of the hospitalist.
You can prolong the duration of use of the drug with additional infusion, if the drug is administered internally over the entire day. The medicine can be prepared on the basis of sodium chloride, aqueous levulose, and dectoside.
The procedural nurses say that people tolerate the drug “Artrosilene” differently. The injections are painful. As you might have already guessed, sometimes the illness lasted for a short time during the procedure. According to the words of some patients, the pain syndrome is not painful and expressive, although it is clear that it is unacceptable. If you take injections in a supine position, the procedure is a little easier to tolerate.
Overdose
Follow up with dosing, vikorista and “Artrosilene” (injections). The evidence of the fakhivtsev shows that improperly draining the face can cause an increase in the self-perception of illness. Unacceptable symptoms appear on the side of the scolio-intestinal tract. The patient may experience fatigue, pain in the mouth, and confusion.
In case of overdose, symptomatic therapy is carried out. The physician may monitor the respiratory and cardiovascular systems.
Side effects
You can provoke a twist side effects"Artrosilene" (injections). Analogues may prevent the appearance of unpleasant symptoms. Therefore, they should be used to treat a specific pathology only after consulting a doctor. On the side of the grass system side effects may appear as abdominal pain, stomatitis, increased activity of liver enzymes, erosive lesions of the intestinal tract.
On the side of the central nervous system, confusion, end tremors, vertigo, and disturbed night sleep were observed. In such cases, the destruction of the dawn is blamed. Please remember that the drug “Artrosilene” (injections) and alcohol are not crazy. Alcohol immediately prevents the development of negative reactions. The most foldable and side effects Cardiovascular system. Patients may experience chest pain, tachycardia, and syncope. Hypertension often develops.
Medical mutualism
It is important to enhance the metabolism of ketoprofen by inducers in the liver, such as phenytoin, ethanol, rifampicin, barbiturates. For aphids, taking the drug "Artrosilen" may reduce the effectiveness of uricosuric drugs. It is not recommended to take the medication with antihypertensive drugs, as well as diuretics.
For other non-steroidal anti-inflammatory drugs, carefully take Artrosilene injections. Instructions to note that such interactions can lead to development virus disease Schulca, as well as Schulculo-intestinal bleeding. There is a greater likelihood of disruption of the function of the nirok.
The drug should be used with caution in people who suffer from diabetes. With one-hour administration of ketoprofen and insulin, the concentration of the remaining substance in the blood may increase. Diabetics need to change the dose before taking a bath.
Artrosilene: instructions from stagnation and use
Latin name: Artrosilene
ATX code: M02AA10
Ducha speech: ketoprofen
Virobnik: Dompe Farmaceutici (Italy), ISTITUTO de ANGELI (Italy), Zellaerosol GmbH (Nimechina), Valpharma S.A. (San Marino), Alfa Wassermann (Italy), Abiogen Pharma S.p.A. (Italy)
Updated description and photo: 09.09.2019
Artrosilene is a drug with analgesic, antipyretic and anti-inflammatory action.
Release form and warehouse
Medicine forms for the release of Artrosilene:
- capsules: gelatin, water-colored, white-colored body and dark-green cap, capsules contain round granules ranging from light yellow to white color (10 pcs per blister, 1 blister per cardboard package);
- doses for internal/internal/lingual administration: prosorious, slightly chewy or barbaric (in black glass ampoules of 2 ml, 6 ampoules per pallet, 1 pallet in a cardboard package);
- rectal suppositories: light yellow to white color, single, torpedo-shaped (5 pcs per strip, 2 strips per cardboard pack);
- gel for external setting: clear, light yellow, with a characteristic odor (30 or 50 g in aluminum tubes, 1 tube in a cardboard package);
- aerosol for external drying: a uniform white or white foam that appears when seen from the can; instead of a cylinder after the gas escapes I can see the countryside light yellow to white color (25 g each in aluminum aerosol cans with a capacity of 25 ml, 1 can in a cardboard package complete with a dry bag and a dispenser nozzle).
Instructions for use with Artrosilene are also available on the skin.
Warehouse 1 capsule:
- active substance: lysinic acid for ketoprofen – 320 mg;
- additional components: povidone – 27.857 mg; diethyl phthalate – 2.286 mg; polymers of methacrylic and acrylic acids - 34.143 mg; carboxypolymethylene – 32.857 mg; talc -27 mg; magnesium stearate – 15.857 mg;
- capsule shell: titanium dioxide (E171), gelatin; cap (additional) - indigotine (E132), quinoline acid (E104).
warehouse: 1 ml dispensing for injections:
- active substance: lysinic acid for ketoprofen – 80 mg;
- additional components: citric acid, sodium hydroxide, water for injection.
Warehouse 1 suppository:
- active substance: lysinic acid for ketoprofen – 160 mg;
- additional component: synthetic glycerides.
Stock 100 mg gel:
- active substance: ketoprofen lysine (lysine salt of ketoprofen) – 5 mg (ketoprofen – 3.125 mg);
- additional components: carbomer – 1 mg; trolamine – 1.9 mg; polysorbate-80 – 0.8 mg; 95% ethanol – 5 mg; methyl parahydroxybenzoate – 0.1 mg; lavender-nerolium flavoring - 0.2 mg; purified water – 0.086 ml.
Warehouse 100 mg aerosol:
- active ingredient: ketoprofen lysine (lysine salt of ketoprofen) – 15 mg (ketoprofen – 9.375 mg);
- additional components: propylene glycol – 4 mg; polysorbate-80 – 4 mg; lavender-nerolium flavoring - 0.2 mg; povidone – 3 mg; sumish propane-butane – 1.25 mg; benzyl alcohol – 0.3 mg; purified water – up to 0.1 ml.
Pharmacological authorities
Pharmacodynamics
Ketoprofen has antipyretic, antipyretic and analgesic effects. Suppresses the synthesis of prostaglandins, inhibiting COX (cyclooxygenase) type I and II. Reveals anti-bradykinin activity, stabilizes lysosomal membranes and inhibits the process of release of enzymes from them, such as chronic fire hide the ruined textiles. The activity of neutrophils decreases and the production of cytokines changes.
When ketoprofen is used, the tenderness of the wound and the swelling of the joints change, and the swelling of the wounds increases. In addition to ketoprofen, ketoprofen lysine salt is a liquid molecule with a neutral pH and may not cause subnasal influx onto the intestinal tract.
When applied to the aerosol or gel, Artrosilene will be protected from mist. jubilant effect for damaged ligaments, muscles, joints, tendons. Ketoprofen does not have a catabolic effect on the subglobular cartilage.
Pharmacokinetics
Capsules, rectal suppositories, injectable doses
Installation:
- capsules: ketoprofen after oral administration may be readily absorbed from the scolio-intestinal tract, its bioavailability becomes over 80%. The max (maximum concentration of speech) in plasma is reached in 4-10 years, and its value is dose-dependent and becomes 3-9 mcg/ml. T 1/2 (nursing period) – 6.5 years. The maximum therapeutic effect lasts for 4-24 years. It decreases Cmax and increases the hour of its reach, at which AUC (the area under the “concentration-hour” curve) does not change;
- Rectal suppositories: ketoprofen will be wetted after rectal stagnation. Reaching hour Cmax – from 45 to 60 hours. The amount of plasma concentration varies linearly with the dose taken.
- Injection dose: when administered parenterally, the maximum time to reach is 20-30 times. Effective concentration is maintained for 24 years. In the synovial region, the therapeutic concentration is maintained for 18 to 20 years;
Plasma proteins, most importantly albumin, account for up to 99% of absorbed ketoprofen. V d (obligatory to the subdivision) is in the range of 0.1 to 0.2 l/kg. It easily penetrates through histohematic barriers and is distributed in organs and tissues. Rechovina penetrates well into healthy tissue and synovial tissue. Although in the synovial region the concentration of ketoprofen is much lower than plasma concentration, it is more stable (stays up to 30 years).
Metabolism of ketoprofen occurs mainly in the liver, where ketoprofen is subject to glucuronidation with further dissolution of folding esters with glucuronic acid.
The release of metabolites occurs from the section. Excreted in feces up to 1%. Chi does not accumulate.
When stagnant, ketoprofen will be completely absorbed.
A dose of 50-150 mg of gel after 5-8 years creates a rhubarb plasma level of 0.08-0.15 mcg/ml. Biological availability of the gel is approximately 5%.
The level of ketoprofen in the blood after application of the aerosol becomes less than 0.1 mcg/ml, the amount of ketoprofen (either pure or conjugated) excreted over the next 48 years, equivalent to 0.62% of the dose of the drug. The dose of ketoprofen in the synovial range is equivalent to 0.2–2 mcg/ml (to be kept at the dose).
Showing before stagnation
Capsules, rectal suppositories
- pain of mild/moderate intensity, including pain of an incendiary nature, post-operative/post-traumatic pain (purchase);
- rheumatic/inflammatory diseases, including spondyloarthritis, osteoarthritis, rheumatoid/gouty arthritis, inflammation of the subglobular tissues (symptomatic inflammation).
Injectional disbursement
Acute pain syndrome due to the presence of onset illnesses/strains (non-trival treatment):
- diseases of the cystic-meat system of various etiologies;
- post-operative/post-traumatic period;
- ignition processes.
Gel, aerosol for external decontamination
- flesh pain of non-rheumatic/rheumatic origin;
- inflammatory diseases of the musculoskeletal system in acute and chronic conditions, including ankylosing spondylitis, rheumatoid/psoriatic arthritis, osteoarthritis of the ridge and peripheral joints, rheumatic diseases of the soft tissues;
- ushkodzhennya soft tissues of traumatic origin.
Contraindicated
Absolute contraindications for Artrosilene for everyone medicinal forms:
- "aspirin triad";
- vaginity ( III trimester) that period of lactation;
- hypersensitivity to the components of Artrosilene, as well as to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs.
Additional absolute contraindications for systemic congestion:
- blood disorders, including hemophilia;
- Virazkova ailment of the gut and duodenum with congestion;
- colitis ulcers when booked;
- diverticulitis;
- Crohn's disease;
- virazaka;
- chronic nitric deficiency;
- century to 18 rocks.
Additional absolute contraindications for external stagnation:
- damage to the integrity of hides;
- eczema;
- weeping dermatoses;
- century to 6 roki.
Notes (the use of Artrosilene in all medicinal forms requires caution for the presence of onset illnesses):
- I and II trimesters of gestation;
- summer century
General contraindications for systemic administration of Artrosilene:
- Tyutyunopalinnya;
- anemia;
- alcoholism;
- sepsis;
- bronchial asthma;
- blood diabetes;
- arterial hypertension;
- bumps;
- hyperbilirubinemia;
- alcoholic liver cirrhosis;
- liver failure;
- dehydration;
- deficiency of glucose-6-phosphate dehydrogenase;
- stomatitis;
- blood diseases, including leukopenia.
General contraindications for external administration of Artrosilene:
- erosive-viral disorder of the sclero-intestinal tract;
- bronchial asthma;
- chronic heart failure;
- hepatic porphyria with acute inflammation;
- severe functional impairment of the liver;
- Vik from 6 to 12 rok.
Artrosilene, instructions from stagnation: method of dosing
Capsules
Artrosilene capsules should be taken internally, most importantly, immediately/after administration.
The additional dose is 1 capsule (1 dose).
It is possible to carry out a three-part course – for 3 to 4 months.
Rectal suppositories
Artrosilene is administered rectally.
Single dose - 1 suppository, frequency of administration - 2-3 times a day.
The maximum dosage is 3 suppositories; for patients with frail eyelids, no more than 2 suppositories per day.
For functional damage to the liver/needles, a reduced dose is required.
Injectional disbursement
Artrosilene injections should be administered internally or internally.
The additional dose is 160 mg.
Maximum – 320 mg per day, for sick people – 160 mg per day.
Artrosilene injections appear to be frozen for a short period of time (up to 3 days), after which the capsules and suppositories can be frozen.
Internally, there are fewer differences between stationary minds. To increase the effectiveness of Artrosilene, it is recommended to carry out large internal infusions - no less than 30 days.
The solution for infusion is prepared on the basis of 50 or 500 ml of the following aqueous solutions: 0.9% sodium chloride solution, 10% aqueous levulose solution, 5% aqueous dextrose solution, Ringer's acetate, Ringer's lactate, Hartmann's solution, col. rozchin 5% from dextrose or 0.9% from sodium chloride.
When diluting Artrosilene in small doses (50 ml), administer it internally as a bolus.
Gel, aerosol for external decontamination
Gel and spray Artrosilen zastosovuyut externally.
Apply the drug 2-3 times a day, rubbing in carefully until completely absorbed.
The duration of the course is up to 10 days (as there are no other purposes for the doctor).
Side activities
- central and peripheral nervous system: extreme anxiety, hyperkinesia, confusion, tremor, vertigo, anxiety, mood swings, twitchiness, hallucinations, blurred vision;
- herbal system: duodenitis, abdominal pain, gastritis, diarrhea, esophagitis, stomatitis, erosive-viral lesions of the scolio-intestinal tract, melena, hematemesis, increased level of bilirubin, liver failure, hepatitis, swelling increased activity of liver enzymes, increased size;
- sechovidal system: sick sechovyazaniya, bumps, cystitis, hematuria;
- Cardiovascular system: syncope, hypertension, tachycardia, hypotension, chest pain, pallor, peripheral swelling;
- hematopoietic system: thrombocytopenia, leukocytopenia, lymphangitis, thrombocytopenic purpura, leukocytosis, change in prothrombin hour, vasculitis, increased size of the spleen;
- respiratory system: laryngeal swelling, laryngeal spasm, bronchospasm, dyspnea, laryngospasm, rhinitis;
- allergic and dermatological reactions: angioedema, urticaria, papilloma exudative erythema(including Stevens-Johnson syndrome), maculopapular swelling, anaphylactoid reactions (swelling of the pharynx, mucous membrane of the empty mouth, periorbital swelling), itching, erythematous exanthema;
- other: destroyed menstrual cycle, conjunctivitis, excessive sweating;
- Local reactions in case of external stagnation: photosensitivity, skin manifestations allergic reactions; with severe stagnation in large areas of the skin, systemic side effects develop;
- Local reactions with frozen suppositories: worsening hemorrhoids, itching, liver pain, heaviness in the anorectal area.
In combination with ketoprofen, lysine salt with ketoprofen adverse reactions screams much less often.
Overdose
Episodes of overdose of Artrosilene during systemic administration have not been recorded. In case of current stagnation, overdose is practically impossible, which is due to the extremely low systemic absorption of ketoprofen.
Therapy: monitoring of cardiac and respiratory activity. For consumption, symptomatic treatment is carried out. There is no specific antidote. Hemodialysis is ineffective.
special inserts
During therapy, periodic monitoring of peripheral blood patterns is required. functional state nirok/pechenki.
If necessary, test 17-ketosteroids Artrosilene 2 days before the investigation.
Therapy can mask the symptoms of an infectious disease.
In case of bronchial asthma, congestion with Artrosilene can lead to the development of a respiratory attack.
This external preparation can be applied only to undamaged areas of the skin. It is necessary to avoid the use of Artrosilene in relation to the mucous membranes.
Aqueous forms of lysine salt of ketoprofen, as well as the original gel, can be used during physiotherapeutic therapy (mesotherapy, iontophoresis): when performing iontophoresis, the drug is applied to the negative pole.
To prevent the appearance of hypersensitivity, during the course of treatment it is recommended to avoid exposure to sleepy symptoms.
Floating to the building to the terminal by motor transport and folding mechanisms
During the course of treatment with Artrosilene, there are potentially dangerous types of work, the elimination of which will require an increased concentration of attention and rapid psychomotor reactions, which will then subside.
Stagnation during gestation and lactation
- III trimester of gestation, period breast support: therapy is contraindicated;
- І and ІІ trimesters of gestation: Artrosilene can be formed only under medical supervision.
Zastosuvannya at the child’s place
Vikovi obezhenya shodo zastosuvannya Artrosilene:
- gel, aerosol: children under 6 years of age – contraindicated; children 6–12 years old – treated with caution;
- capsules, injectable doses, rectal suppositories: contraindicated for children under 18 years of age.
If the function of the nirok is impaired
Arthrosilene in the form of capsules, the use of suppositories for chronic nitric deficiency is contraindicated.
Aerosol and gel Artrosilene in case of severe damage to the nitric function should be used with caution.
In case of impaired liver function
The use of Artrosilene requires caution:
- capsules, formulations and suppositories: for patients with alcoholic cirrhosis of the liver and liver failure;
- gel, aerosol: for severe impairment of liver function.
Zastosuvannya at the Summer Palace
For elderly patients, Artrosilene is prescribed with caution.
Medical mutualism
With one-hour administration of Artrosilene with certain drugs/medicines, the following effects may develop:
- inducers of microsomal oxidation in the liver, including ethanol, tricyclic antidepressants, phenytoin, phenylbutazone, barbiturates, rifampicin, flumecinol: increased metabolism of ketoprofen (increased production is expected ii hydroxylated active metabolites);
- anticoagulants, antiplatelet agents, fibrinolytics, ethanol: strengthening of their action;
- Uricosuric, antihypertensive drugs, diuretics: decreased effectiveness;
- other non-steroidal anti-inflammatory drugs, glucocorticosteroids, ethanol, corticotropin: increased potency of the drug and increased risk of intestinal bleeding, functional damage nirok;
- mineralocorticoids, glucocorticoids, estrogens: increased severity of their side effects;
- Insulin and oral hypoglycemic drugs: enhancement of hypoglycemic action (dose adjustment may be necessary);
- oral anticoagulants, heparin, thrombolytics, antiplatelet agents, cefoperazone, cefamandole and cefotetan: increased incidence of bleeding;
- verapamil, nifedipine, lithium, methotrexate: increases in plasma concentrations;
- sodium valproate: Impaired platelet aggregation;
- cholestyramine, antacids: decreased absorption of ketoprofen.
Analogs
Analogs of Artrosilene: Febrofid, Ketoprofen, Fastum, Oruvel, Spazgel, Ketospray, Flexen, VALUSAL, Artrum, Ketonal, Bistrumgel.
Terms and minds saving
Store in a protected, dark place, out of reach of children, at temperatures up to 25 °C. The aerosol can cannot be overheated.
Term of attribution:
- capsules, rectal suppositories – 5 days;
- injections, gel, aerosol – 3 pieces.
Umovi dispensers from pharmacies
Available:
- capsules, doses, suppositories: for prescription;
- gel, aerosol: without prescription.
Artrosilene - injections based on ketoprofen, intended for sleep apnea severe pain for rheumatism and other illnesses of the skeletal-meat system. The drug should be included in the group of non-steroidal anti-inflammatory drugs (NSAIDs). Its active component, ketoprofen, is similar to propionic acid and is included in life for medicinal purposes that are important for people.
Taking the drug allows you to change the intensity of the ignition process, relieve pain syndrome and lower body temperature. Artrosilene is contraindicated and may lead to the development of systemic side effects. To avoid the negative effect of the drug on the body, follow the doctor’s recommendation.
Personal medical form
Artrosilene injections are produced in Italy by the pharmaceutical company Dompe Pharmaceutichi S.P.A. The drug is produced in the form of a clear, barless or light yellow sterile bottle intended for intralingual or intravenous administration. Likuvalna Ridina is bottled in 2 ml ampoules from a dark bottle. Ampoules are packaged in 6 pieces in a plastic tray. In the middle of the individual packaging there is 1 tray of ampoules and instructions for drying until ready for use.
Components and action
The pharmacological action of Artrosilene is provided by ketoprofen, which is known as lysine salt. Its concentration in 1 ml becomes 80 mg. In addition, sodium hydroxide, citric acid and sterile water must be added to the warehouse.
Ketoprofen lysine salt, when administered internally or internally, exhibits pronounced analgesic, antipyretic and antipyretic activity, changes the swelling of the joints and promotes their friability. The action of the head component is due to its negative influence on cyclooxygenase-1 and cyclooxygenase-2 and the galvanic biosynthesis of prostaglandins. Artrosilene has an anti-bradykinin effect, stabilizes the membranes of lysosomes and promotes the release of enzymes from them, which provokes inflammation and destruction of healthy tissue.
The drug practically does not penetrate the mucous membrane of the organs of the herbal tract and does not provoke a catabolic effect on the cartilage.
If you use the drug
Artrosilene is formulated in ampoules to relieve acute pain in the joints and muscles. The following are indications for vikoristan:
- rheumatism;
- arthritis (rheumatoid, psoriatic, reactive arthritis);
- arthrosis of various localizations;
- gout;
- ankylosing spondylitis;
- bursitis;
- osteochondrosis of the ridge;
- synovitis;
- tenosynovitis;
- enthesopathies;
- myalgia;
- conditions after injuries and surgical procedures.
Method of curing
Likarsky Rozchin Artrosilene is intended for administration internally or internally. Treatment with the drug slid is carried out in hospital facilities under the supervision of a doctor.
Additional dosage for the individual and the triviality of this stagnation lie in the background clinical picture and are designated as fakhivets. The maximum period of treatment is not required to exceed 3 days after sleep. Instead of the ampoule, it is necessary to dissolve immediately after dissolution.
The parts that are lost after the injection cannot be saved. This trace should be disposed of immediately from the opened ampoule.
Custody until celebration
In medicine, Artrosilene is a contraindication, and a list of which patients should be familiar with before starting treatment. The drug is contraindicated when:
- increased sensitivity to speeches that enter into your warehouse;
- individual intolerance to NSAIDs;
- nirka deficiency;
- infection of the scutum and 12-fingered intestine;
- granulomatous enteritis;
- colonic diverticulosis;
- aspirin bronchial asthma;
- impaired throat blood;
- vagusity;
- Breast bath.
Use for injection Artrosilene is not approved for the treatment of children and children. Its use is allowed to patients over 18 years of age.
The drug should be used with caution in medically treated summer patients and those who suffer from chronic heart failure, bronchial asthma, important liver pathologies, alcoholism, Hypertensive disease, peripheral plaques, anemia and sepsis.
Artrosilene negatively influences the speed of psychomotor reactions and the concentration of respect, so when people become stagnant, they need to get rid of keratin in terms of transport and robots on potentially unsafe objects.
Side symptoms
The need for injections of Artrosilene can lead to the development of undesirable reactions in the patient in various organs and systems. Before the most widespread side effects, the physician must:
- ailments in the stomach;
- infection of the mucous membrane of the SCT;
- tediousness;
- constipation and diarrhea;
- confused;
- nervousness;
- cystitis;
- bumps;
- change arterial pressure (hypertension or hypotension);
- increased pulse rate;
- show allergies (wheezing and itching on the skin, Quincke's bump);
- more sweating;
- Disruption of the menstrual cycle.
In addition to overreactions, side effects to the drug may manifest as decreased visual acuity, hallucination, increased size of the liver and spleen, liver failure, changes in chemical warehouse blood, bronchospasm, laryngospasm, Stevens-Johnson syndrome.
If you experience any of the described effects, you should consult a doctor to see if you can continue treatment.
Medication and overdose
During the period of treatment with Artrosilene, patients should carefully remove medications that may enter into a drug interaction.
Injection doses should not be combined with antacids, glucocorticoids, NSAIDs, methotrexate, cholestyramine, verapamil, cefamandole, ticlopidine, heparin, spironolactone, probenecid, tramadol, peripheral vasodilator ah, antitrom.
Data about overdose of the medicinal drug Artrozilen daily. Scientists admit that overdosage may provoke an increase in unwanted reactions in patients.
Vartіst and vіdguki
The effectiveness of Artrosilene is indicated by the number of patients treated. People who are victorious in the medical department for the removal of severe pain, denote your Swedish analgesic validity and trival duty (up to 12 years).
Products for injection Artrosilene are intended for prescription sale in pharmacies. The average price of one package of the drug is 200 rubles. Store ampoules with a medicinal trace in a protected manner by direct washing at a room temperature of no more than 25°C.
3416 0
The drug Arthrosilene, which is in stock the main active ingredient Ketoprofen, which is widely used in inflammatory processes of subcutaneous tissues, which is accompanied by advanced illness.
Artrosilene is available in different forms:
- capsules for oral administration;
- injections for internal lingual and internal injections;
- gel for external drying;
- an aerosol that will solidify externally;
- suppository for rectal vicinity.
Pharmacological action
As a non-steroidal anti-inflammatory drug, Artrosilene suppresses chronic inflammatory processes, inhibits the activity of enzymes that destroy tissue, suppresses the synthesis of prostaglandins, inhibits COX-1 and COX-2.
Although it has a slightly insignificant negative effect on the scolial-intestinal tract, the drug gives a good therapeutic result, as an analgesic, it also has an antipyretic effect.
When injected with the drug, the sick know the ability to dissolve the necessary care of the body, there is a feeling of boredom after a period of rest, and the tissue swelling decreases. When administered orally, the maximum effect is achieved after 4 years.
The action of modern drugs is analgesic, protinabryakova, stagnant and anti-inflammatory for the treatment of joints and soft tissues: meat, tendons, ligaments.
Pharmacokinetics of drugs
Administered in an oral form, the drug in capsules gives the maximum effect after 4 years, the stability of the result remains with the dose of the drug taken, the bioavailability exceeds 80%, when administered parenterally, the maximum concentration in the synovial region appears after one time, and the therapeutic effect lasts longer, less when other conditions are stagnant forms, up to 24 years.
When administered rectally, the absorption rate of the drug and its therapeutic effect are also high, and when administered externally, the drug is absorbed completely, the bioavailability reaches 5%.
By binding to plasma proteins, the active substance ketoprofen is readily distributed in organs and tissues, in the synovial region, and in related tissue. Metabolism of the drug occurs in the liver. Metabolic products are eliminated by stretching the water.
Showing before stagnation
It is important for the Artrosilene form to stagnate in the following situations: 
- Zastosovuvanny internal capsules and suppositories They are used as analgesics for post-operative pain, for pain after relapse or for lingering pain, which indicates the presence of inflammation in the suprapubic tissues. The drugs are prescribed for Various types, ignited
- Arrange for injections Be aware of acute pain syndrome, post-operative pain, and inflammation of periarticular tissues of various types.
- Gels and aerosols Stagnation is more common due to soft tissue injuries and injuries; with osteoarthritis of the ridge; for ulcer pain of a non-rheumatic nature.
Contraindicated before use
Contraindications for taking any form of the drug:
- individual intolerance to active speech, hypersensitivity to it or other non-steroidal anti-inflammatory drugs;
- aspirin asthma;
- Virazkov's disease and Virazkov's colitis, Crohn's disease;
- diverticulitis;
- hemophilia and other laryngeal disorders;
- chronic nitric deficiency;
- lactation period.
Children's eyelids are contraindicated for the use of the drug in all types, including gel and aerosols.
During the hour of pregnancy, the drug is prescribed with caution only as an external dose during the third period of pregnancy.
Action mechanism
The active ingredient of the drug ketoprofen is 99%, penetrates into the blood plasma, binds to albumin and is distributed in tissues, suppressing the synthesis of prostaglandins and inhibiting COX-1 and COX-2, suppressing the activity of diseases beneficial enzymes.
How to stiffen the faces?
Be sure to follow the release form and instructions before curing Artrosilene.
The drug is released:
Report on dosing
Arthrosilene should be taken internally before or after 3 or 4 months, one capsule per day.
internally or internally in a gradual mode of administration, internally 500 ml for 30 days, one ampoule no more than two times per day for 3 days.
Injections are carried out at the hospital. Prepared rozchini trace vikoristuvat negay.
One suppository is administered rectally 2-3 times a day, the maximum dose per dose is more than 480 mg.
The external drug is applied in a quantity that appears to have a flat, painful surface, and no more than 5 g per application for a cured gel and no more than 2 g for a cured aerosol, pea size And then drink a teaspoon every day in a course of no more than 10 days.
Once overdosed
If there is a suspicion that the permissible dose of the drug has been exceeded, monitor respiratory and cardiac activity and, if any damage is detected, initiate symptomatic therapy.
Side activities
Side effects that occur when taking the drug can be characterized by immediate changes:
- the herbal system suffers from virulent disorders, the patient experiences abdominal pain and diarrhea;
- the hematopoietic system reacts to an increase in the level of bilirubin and an increase in the activity of liver enzymes, the size of the liver exceeds the norm;
- the nervous system reacts to extreme illnesses, fleeting tremors, and anxiety;
- may cause lacrimation, problems with vision;
- various types of skin allergies;
- cystitis, hematuria. disruption of the menstrual cycle;
- bronchospasm, laryngeal spasm, rhinitis;
- tachycardia, swelling, hyperhypotension.
- allergic reactions: anaphylactic reactions, mucosal plaque, pharynx, periorbital plaque.
Allergic reactions to the suppository may appear within a few years after administration of the drug: itching, liver problems, hemorrhoids and acute inflammation.
If, against the background of taking the drug, the patient’s condition has become worse or more signs have appeared, it is necessary to consult with the doctor.
special inserts
In case of excessive dryness, skin dermatoses and eczema may also occur. In case of bronchial asthma, the drug is prescribed with caution, as well as in the elderly.
Capsules are not suitable for anemia, Cultural diabetes, sepsis, swelling, advanced arterial pressure, stomatitis, childish up to 12 days.
Capsules prepared for administration and suppositories are contraindicated for alcoholism.
In case of severe impairment of liver function, this drug should not be prescribed.
Internal medications taken during lactation are contraindicated. Also contraindications for the third period of pregnancy.
Gels and aerosols should be frozen during the first and second periods of pregnancy if absolutely necessary under the supervision of a doctor.
Internal medications are not prescribed to persons who have not reached the age of 18. Gels and aerosols will solidify after reaching the patient for 12 days.
Interactions with other drugs
Barbiturates and tricyclic antidepressants enhance the activity of ketoprofen.
The effect of anticoagulants will increase, the effect of diuretics will decrease, and the side effects of glucocorticoids will increase.
At the same time, the use of other anticoagulants will increase the risk of bleeding.
If insulin is used, the dose should be determined differently. The virobulation of platelets flows in.
Vivchimo qualified thought
The doctor’s call, who is a vikorist in his practice, is Artrosilene.
When prescribing a drug, we carefully consider the history of the patient’s illness. It is important to note that this person does not have any illness in the hematopoietic or other organs.
The drug works without harm and has helped hundreds of sick people. The course of taking capsules lasts up to 4 months. Injections cannot be taken for a long time.
Doctor of the orthopedic clinic, Khanaev V.P.